Q9JT70 · DHPS_NEIMA
- ProteinDihydropteroate synthase
- GenefolP
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids283 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Catalytic activity
- (7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 25 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 66 | (7,8-dihydropterin-6-yl)methyl diphosphate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 99 | (7,8-dihydropterin-6-yl)methyl diphosphate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 119 | (7,8-dihydropterin-6-yl)methyl diphosphate (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 190 | (7,8-dihydropterin-6-yl)methyl diphosphate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 227 | (7,8-dihydropterin-6-yl)methyl diphosphate (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 262-264 | (7,8-dihydropterin-6-yl)methyl diphosphate (UniProtKB | ChEBI) | ||||
Sequence: RVH |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dihydropteroate synthase activity | |
Molecular Function | metal ion binding | |
Biological Process | folic acid biosynthetic process | |
Biological Process | tetrahydrofolate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydropteroate synthase
- EC number
- Short namesDHPS
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria
Accessions
- Primary accessionQ9JT70
- Secondary accessions
Proteomes
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 2-4 | in strain: 1014 and 418 | ||||
Sequence: VGC → ARH | ||||||
Natural variant | 31 | in strain: 1014 and 418 | ||||
Sequence: L → F | ||||||
Natural variant | 68 | in strain: 418 | ||||
Sequence: P → L | ||||||
Natural variant | 75 | in strain: 1014 | ||||
Sequence: P → S | ||||||
Natural variant | 84 | in strain: 1014 and 418 | ||||
Sequence: S → P | ||||||
Natural variant | 87 | in strain: 418 | ||||
Sequence: A → E | ||||||
Natural variant | 87 | in strain: 1014 | ||||
Sequence: A → V | ||||||
Natural variant | 102 | in strain: 1014 and 418 | ||||
Sequence: H → R | ||||||
Natural variant | 105 | in strain: 418 | ||||
Sequence: V → I | ||||||
Natural variant | 115 | in strain: 418 | ||||
Sequence: I → V | ||||||
Natural variant | 125 | in strain: 418 | ||||
Sequence: T → N | ||||||
Natural variant | 130 | in strain: 418 | ||||
Sequence: L → V | ||||||
Natural variant | 135 | in strain: 418 | ||||
Sequence: C → R | ||||||
Natural variant | 147 | in strain: 1014 | ||||
Sequence: Q → R | ||||||
Natural variant | 151 | in strain: 1014 | ||||
Sequence: K → E | ||||||
Natural variant | 152 | in strain: 418 | ||||
Sequence: N → T | ||||||
Natural variant | 174 | in strain: 418 | ||||
Sequence: A → S | ||||||
Natural variant | 188 | in strain: 418 | ||||
Sequence: T → I | ||||||
Natural variant | 194 | in strain: 1014 | ||||
Sequence: C → G | ||||||
Natural variant | 194 | in strain: 418 | ||||
Sequence: C → GSG | ||||||
Natural variant | 198 | in strain: 418 | ||||
Sequence: T → P | ||||||
Natural variant | 204 | in strain: 1014 and 418 | ||||
Sequence: T → A | ||||||
Natural variant | 218 | in strain: 1014 and 418 | ||||
Sequence: Y → F | ||||||
Natural variant | 228 | in strain: 1014 | ||||
Sequence: S → R | ||||||
Natural variant | 229 | in strain: 418 | ||||
Sequence: M → T | ||||||
Natural variant | 230 | in strain: 1014 | ||||
Sequence: I → V | ||||||
Natural variant | 237-238 | in strain: 418 | ||||
Sequence: TD → AN | ||||||
Natural variant | 241 | in strain: 418 | ||||
Sequence: A → E | ||||||
Natural variant | 243 | in strain: 1014 and 418 | ||||
Sequence: G → V | ||||||
Natural variant | 253 | in strain: 1014 and 418 | ||||
Sequence: A → S | ||||||
Natural variant | 255 | in strain: 1014 | ||||
Sequence: A → R | ||||||
Natural variant | 259 | in strain: 1014 and 418 | ||||
Sequence: K → Q | ||||||
Natural variant | 275 | in strain: 1014 and 418 | ||||
Sequence: A → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 33 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000168217 | 1-283 | Dihydropteroate synthase | |||
Sequence: MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL |
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 18-274 | Pterin-binding | ||||
Sequence: PKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALK |
Sequence similarities
Belongs to the DHPS family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length283
- Mass (Da)29,928
- Last updated2000-10-01 v1
- Checksum89A0976A527C9E27
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X68065 EMBL· GenBank· DDBJ | CAA48202.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X68068 EMBL· GenBank· DDBJ | CAA48205.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL157959 EMBL· GenBank· DDBJ | CAM09062.1 EMBL· GenBank· DDBJ | Genomic DNA |