Q9JT70 · DHPS_NEIMA

Function

function

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site25Mg2+ (UniProtKB | ChEBI)
Binding site66(7,8-dihydropterin-6-yl)methyl diphosphate (UniProtKB | ChEBI)
Binding site99(7,8-dihydropterin-6-yl)methyl diphosphate (UniProtKB | ChEBI)
Binding site119(7,8-dihydropterin-6-yl)methyl diphosphate (UniProtKB | ChEBI)
Binding site190(7,8-dihydropterin-6-yl)methyl diphosphate (UniProtKB | ChEBI)
Binding site227(7,8-dihydropterin-6-yl)methyl diphosphate (UniProtKB | ChEBI)
Binding site262-264(7,8-dihydropterin-6-yl)methyl diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondihydropteroate synthase activity
Molecular Functionmetal ion binding
Biological Processfolic acid biosynthetic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydropteroate synthase
  • EC number
  • Short names
    DHPS
  • Alternative names
    • Dihydropteroate pyrophosphorylase

Gene names

    • Name
      folP
    • Synonyms
      dhpS
    • Ordered locus names
      NMA1950

Organism names

Accessions

  • Primary accession
    Q9JT70
  • Secondary accessions
    • A1ITE8

Proteomes

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant2-4in strain: 1014 and 418
Natural variant31in strain: 1014 and 418
Natural variant68in strain: 418
Natural variant75in strain: 1014
Natural variant84in strain: 1014 and 418
Natural variant87in strain: 418
Natural variant87in strain: 1014
Natural variant102in strain: 1014 and 418
Natural variant105in strain: 418
Natural variant115in strain: 418
Natural variant125in strain: 418
Natural variant130in strain: 418
Natural variant135in strain: 418
Natural variant147in strain: 1014
Natural variant151in strain: 1014
Natural variant152in strain: 418
Natural variant174in strain: 418
Natural variant188in strain: 418
Natural variant194in strain: 1014
Natural variant194in strain: 418
Natural variant198in strain: 418
Natural variant204in strain: 1014 and 418
Natural variant218in strain: 1014 and 418
Natural variant228in strain: 1014
Natural variant229in strain: 418
Natural variant230in strain: 1014
Natural variant237-238in strain: 418
Natural variant241in strain: 418
Natural variant243in strain: 1014 and 418
Natural variant253in strain: 1014 and 418
Natural variant255in strain: 1014
Natural variant259in strain: 1014 and 418
Natural variant275in strain: 1014 and 418

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 33 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001682171-283Dihydropteroate synthase

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-274Pterin-binding

Sequence similarities

Belongs to the DHPS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    283
  • Mass (Da)
    29,928
  • Last updated
    2000-10-01 v1
  • Checksum
    89A0976A527C9E27
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X68065
EMBL· GenBank· DDBJ
CAA48202.1
EMBL· GenBank· DDBJ
Genomic DNA
X68068
EMBL· GenBank· DDBJ
CAA48205.1
EMBL· GenBank· DDBJ
Genomic DNA
AL157959
EMBL· GenBank· DDBJ
CAM09062.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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