Q9JLY0 · SOCS6_MOUSE
- ProteinSuppressor of cytokine signaling 6
- GeneSocs6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids533 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity).
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | immunological synapse | |
Cellular Component | phosphatidylinositol 3-kinase complex | |
Molecular Function | 1-phosphatidylinositol-3-kinase regulator activity | |
Biological Process | intracellular signal transduction | |
Biological Process | negative regulation of signal transduction | |
Biological Process | negative regulation of T cell activation | |
Biological Process | phosphatidylinositol phosphate biosynthetic process | |
Biological Process | proteasomal protein catabolic process | |
Biological Process | protein ubiquitination | |
Biological Process | regulation of growth |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuppressor of cytokine signaling 6
- Short namesSOCS-6
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9JLY0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000181252 | 1-533 | Suppressor of cytokine signaling 6 | |||
Sequence: MKKISLKTFRKSFNLSKSKDETEFMVVQPQSLAGDFVKDDSLFGSCYGKDMASCDIGSEDEKGKNRSKSESLMGTLKRRLSAKQKTKGKGGTASTDEDTFSSASAPGGLKDVRAPRPIRSTSLRSHHYSPTPWPLRPTSSEETCIKMEMRVKALVHAASPGPVNGVRKDLRELQPRELRDLQPEPRPESRCSPSSPGDLSLHLEEHVPVVIGLMSQDYLQYTVPLDDGMCPLEGPRSCCLDTSSPMEVSAVPLPGASGAFSEDDSHVDQDLVVGPEILVDSSVNNLLIGTTGVMLQSPRGGHDDAPPLSPLLPPMQNNPIQRNFSGLSGPDLHMAESVRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with KIT (phosphorylated) (By similarity).
Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3
Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
XENO | Q9JLY0 | RBCK1 Q9BYM8 | 5 | EBI-8500205, EBI-2340624 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 54-73 | Basic and acidic residues | ||||
Sequence: CDIGSEDEKGKNRSKSESLM | ||||||
Region | 54-136 | Disordered | ||||
Sequence: CDIGSEDEKGKNRSKSESLMGTLKRRLSAKQKTKGKGGTASTDEDTFSSASAPGGLKDVRAPRPIRSTSLRSHHYSPTPWPLR | ||||||
Compositional bias | 87-102 | Polar residues | ||||
Sequence: KGKGGTASTDEDTFSS | ||||||
Compositional bias | 122-136 | Polar residues | ||||
Sequence: SLRSHHYSPTPWPLR | ||||||
Region | 177-199 | Disordered | ||||
Sequence: ELRDLQPEPRPESRCSPSSPGDL | ||||||
Domain | 382-489 | SH2 | ||||
Sequence: WYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPV | ||||||
Domain | 484-533 | SOCS box | ||||
Sequence: RLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY |
Domain
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length533
- Mass (Da)59,077
- Last updated2011-07-27 v2
- ChecksumF779C6519DB0A17B
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
D3Z776 | D3Z776_MOUSE | Socs6 | 180 | ||
A0A494BA19 | A0A494BA19_MOUSE | Socs6 | 65 | ||
A0A1C7ZMY9 | A0A1C7ZMY9_MOUSE | Socs6 | 8 |
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 10 | in Ref. 1; AAF28872 | ||||
Sequence: R → T | ||||||
Compositional bias | 54-73 | Basic and acidic residues | ||||
Sequence: CDIGSEDEKGKNRSKSESLM | ||||||
Compositional bias | 87-102 | Polar residues | ||||
Sequence: KGKGGTASTDEDTFSS | ||||||
Sequence conflict | 92 | in Ref. 1; AAF28872 | ||||
Sequence: T → S | ||||||
Compositional bias | 122-136 | Polar residues | ||||
Sequence: SLRSHHYSPTPWPLR | ||||||
Sequence conflict | 149-152 | in Ref. 1; AAF28872 | ||||
Sequence: MRVK → IASE | ||||||
Sequence conflict | 308 | in Ref. 2; BAB31956 | ||||
Sequence: L → I |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF121907 EMBL· GenBank· DDBJ | AAF28872.1 EMBL· GenBank· DDBJ | mRNA | ||
AK019993 EMBL· GenBank· DDBJ | BAB31956.1 EMBL· GenBank· DDBJ | mRNA | ||
AK028665 EMBL· GenBank· DDBJ | BAC26055.1 EMBL· GenBank· DDBJ | mRNA | ||
AK028701 EMBL· GenBank· DDBJ | BAC26074.1 EMBL· GenBank· DDBJ | mRNA | ||
AK031164 EMBL· GenBank· DDBJ | BAC27287.1 EMBL· GenBank· DDBJ | mRNA | ||
AK044946 EMBL· GenBank· DDBJ | BAC32154.1 EMBL· GenBank· DDBJ | mRNA | ||
AK142069 EMBL· GenBank· DDBJ | BAE24930.1 EMBL· GenBank· DDBJ | mRNA | ||
AK156591 EMBL· GenBank· DDBJ | BAE33770.1 EMBL· GenBank· DDBJ | mRNA | ||
CH466632 EMBL· GenBank· DDBJ | EDL00645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH466632 EMBL· GenBank· DDBJ | EDL00646.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC017597 EMBL· GenBank· DDBJ | AAH17597.1 EMBL· GenBank· DDBJ | mRNA | ||
BC094443 EMBL· GenBank· DDBJ | AAH94443.1 EMBL· GenBank· DDBJ | mRNA |