Q9JLY0 · SOCS6_MOUSE

  • Protein
    Suppressor of cytokine signaling 6
  • Gene
    Socs6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity).

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentimmunological synapse
Cellular Componentphosphatidylinositol 3-kinase complex
Molecular Function1-phosphatidylinositol-3-kinase regulator activity
Biological Processintracellular signal transduction
Biological Processnegative regulation of signal transduction
Biological Processnegative regulation of T cell activation
Biological Processphosphatidylinositol phosphate biosynthetic process
Biological Processproteasomal protein catabolic process
Biological Processprotein ubiquitination
Biological Processregulation of growth

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Suppressor of cytokine signaling 6
  • Short names
    SOCS-6
  • Alternative names
    • Cytokine-inducible SH2 protein 4 (CIS-4)
    • Suppressor of cytokine signaling 4 (SOCS-4)

Gene names

    • Name
      Socs6
    • Synonyms
      Cis4, Cish4, Socs4

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • NOD
    • Czech II
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9JLY0
  • Secondary accessions
    • Q8VEN5
    • Q9D2A0

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001812521-533Suppressor of cytokine signaling 6

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with KIT (phosphorylated) (By similarity).
Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
XENO Q9JLY0RBCK1 Q9BYM85EBI-8500205, EBI-2340624

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias54-73Basic and acidic residues
Region54-136Disordered
Compositional bias87-102Polar residues
Compositional bias122-136Polar residues
Region177-199Disordered
Domain382-489SH2
Domain484-533SOCS box

Domain

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    533
  • Mass (Da)
    59,077
  • Last updated
    2011-07-27 v2
  • Checksum
    F779C6519DB0A17B
MKKISLKTFRKSFNLSKSKDETEFMVVQPQSLAGDFVKDDSLFGSCYGKDMASCDIGSEDEKGKNRSKSESLMGTLKRRLSAKQKTKGKGGTASTDEDTFSSASAPGGLKDVRAPRPIRSTSLRSHHYSPTPWPLRPTSSEETCIKMEMRVKALVHAASPGPVNGVRKDLRELQPRELRDLQPEPRPESRCSPSSPGDLSLHLEEHVPVVIGLMSQDYLQYTVPLDDGMCPLEGPRSCCLDTSSPMEVSAVPLPGASGAFSEDDSHVDQDLVVGPEILVDSSVNNLLIGTTGVMLQSPRGGHDDAPPLSPLLPPMQNNPIQRNFSGLSGPDLHMAESVRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D3Z776D3Z776_MOUSESocs6180
A0A494BA19A0A494BA19_MOUSESocs665
A0A1C7ZMY9A0A1C7ZMY9_MOUSESocs68

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict10in Ref. 1; AAF28872
Compositional bias54-73Basic and acidic residues
Compositional bias87-102Polar residues
Sequence conflict92in Ref. 1; AAF28872
Compositional bias122-136Polar residues
Sequence conflict149-152in Ref. 1; AAF28872
Sequence conflict308in Ref. 2; BAB31956

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF121907
EMBL· GenBank· DDBJ
AAF28872.1
EMBL· GenBank· DDBJ
mRNA
AK019993
EMBL· GenBank· DDBJ
BAB31956.1
EMBL· GenBank· DDBJ
mRNA
AK028665
EMBL· GenBank· DDBJ
BAC26055.1
EMBL· GenBank· DDBJ
mRNA
AK028701
EMBL· GenBank· DDBJ
BAC26074.1
EMBL· GenBank· DDBJ
mRNA
AK031164
EMBL· GenBank· DDBJ
BAC27287.1
EMBL· GenBank· DDBJ
mRNA
AK044946
EMBL· GenBank· DDBJ
BAC32154.1
EMBL· GenBank· DDBJ
mRNA
AK142069
EMBL· GenBank· DDBJ
BAE24930.1
EMBL· GenBank· DDBJ
mRNA
AK156591
EMBL· GenBank· DDBJ
BAE33770.1
EMBL· GenBank· DDBJ
mRNA
CH466632
EMBL· GenBank· DDBJ
EDL00645.1
EMBL· GenBank· DDBJ
Genomic DNA
CH466632
EMBL· GenBank· DDBJ
EDL00646.1
EMBL· GenBank· DDBJ
Genomic DNA
BC017597
EMBL· GenBank· DDBJ
AAH17597.1
EMBL· GenBank· DDBJ
mRNA
BC094443
EMBL· GenBank· DDBJ
AAH94443.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp