Q9JLI6 · SCLY_MOUSE

  • Protein
    Selenocysteine lyase
  • Gene
    Scly
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
9.9 mML-selenocysteine
8.6 mML-cysteine sulfinate
5.2 mML-cysteine
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
58 μmol/min/mgwith L-selenocysteine as substrate
0.45 μmol/min/mgwith L-cysteine sulfinate as substrate
0.0074 μmol/min/mgwith L-cysteine as substrate

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site375S-selanylcysteine intermediate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionselenocysteine lyase activity
Molecular Functiontransferase activity
Biological Processlipid metabolic process
Biological Processnegative regulation of cellular response to oxidative stress
Biological Processresponse to insulin
Biological Processselenium compound metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Selenocysteine lyase
  • EC number
  • Short names
    mSCL

Gene names

    • Name
      Scly
    • Synonyms
      Scl

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9JLI6
  • Secondary accessions
    • Q8CB57
    • Q8CB94

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00003170131-432Selenocysteine lyase
Modified residue117Phosphoserine
Modified residue247N6-(pyridoxal phosphate)lysine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed. Present in liver, kidney, testis (at protein level).

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9JLI6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    432
  • Mass (Da)
    47,174
  • Last updated
    2000-10-01 v1
  • Checksum
    AFC1800A1BC349D4
MDAARNGALGSVESLPDRKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVSGRKAKDIINAARASLAKMIGGKPQDIIFTSGGTESNNLVIHSMVRCFHEQQTLKGNMVDQHSPEEGTRPHFITCTVEHDSIRLPLEHLVENQMAEVTFVPVSKVNGQAEVEDILAAVRPTTCLVTIMLANNETGVIMPVSEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDVEDLGVDFLTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAADLVSENCETYEAHMRDIRDYLEERLEAEFGKRIHLNSRFPGVERLPNTCNFSIQGSQLQGYTVLAQCRTLLASVGASCHSNHEDRPSPVLLSCGIPVDVARNAVRLSVGRGTTRADVDLIVQDLKQAVAQLEGRL

Q9JLI6-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
M0QWF1M0QWF1_MOUSEScly61
F7BB44F7BB44_MOUSEScly216
A0A0R4J069A0A0R4J069_MOUSEScly432
F6ZFP8F6ZFP8_MOUSEScly249
F7D651F7D651_MOUSEScly218
D3Z7G6D3Z7G6_MOUSEScly245
D3Z3I6D3Z3I6_MOUSEScly68

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict146in Ref. 2; BAC29465
Sequence conflict278in Ref. 2; BAC29465/BAC29563
Alternative sequenceVSP_030855284-432in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF175407
EMBL· GenBank· DDBJ
AAF36812.1
EMBL· GenBank· DDBJ
mRNA
AK036533
EMBL· GenBank· DDBJ
BAC29465.1
EMBL· GenBank· DDBJ
mRNA
AK036750
EMBL· GenBank· DDBJ
BAC29563.1
EMBL· GenBank· DDBJ
mRNA
BC019879
EMBL· GenBank· DDBJ
AAH19879.1
EMBL· GenBank· DDBJ
mRNA
BC021389
EMBL· GenBank· DDBJ
AAH21389.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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