Q9JL19 · NCOA6_MOUSE

  • Protein
    Nuclear receptor coactivator 6
  • Gene
    Ncoa6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthistone methyltransferase complex
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componentprotein-containing complex
Cellular Componenttranscription regulator complex
Molecular Functionchromatin binding
Molecular Functionchromatin-protein adaptor activity
Molecular Functionhistone methyltransferase binding
Molecular Functionidentical protein binding
Molecular Functionnuclear estrogen receptor binding
Molecular Functionnuclear glucocorticoid receptor binding
Molecular Functionnuclear receptor coactivator activity
Molecular Functionnuclear retinoic acid receptor binding
Molecular Functionnuclear retinoid X receptor binding
Molecular Functionnuclear thyroid hormone receptor binding
Molecular Functionnuclear vitamin D receptor binding
Molecular Functionperoxisome proliferator activated receptor binding
Molecular Functionprotein domain specific binding
Molecular Functiontranscription coactivator activity
Biological Processbrain development
Biological ProcessDNA damage response
Biological Processheart development
Biological Processlabyrinthine layer blood vessel development
Biological Processmyeloid cell differentiation
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Processpositive regulation of peptide secretion
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of gene expression

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear receptor coactivator 6
  • Alternative names
    • Activating signal cointegrator 2 (ASC-2)
    • Amplified in breast cancer protein 3
    • Cancer-amplified transcriptional coactivator ASC-2
    • Nuclear receptor coactivator RAP250 (NRC)
    • Nuclear receptor-activating protein, 250 kDa

Gene names

    • Name
      Ncoa6
    • Synonyms
      Aib3, Prip, Rap250, Trbp

Organism names

  • Taxonomic identifier
  • Strain
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9JL19
  • Secondary accessions
    • Q9JLT9

Proteomes

Organism-specific databases

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis891-894Abolishes interaction with nuclear receptors.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000944141-2067Nuclear receptor coactivator 6
Modified residue95Asymmetric dimethylarginine
Modified residue888Phosphoserine
Modified residue1050Asymmetric dimethylarginine
Modified residue1061Asymmetric dimethylarginine
Modified residue1099Asymmetric dimethylarginine
Modified residue1822N6-acetyllysine
Modified residue1825N6-acetyllysine
Modified residue2022Phosphoserine

Post-translational modification

Phosphorylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed. High expression in testis and weak expression in small intestine.

Developmental stage

Expressed at 9 dpc in placenta and at weaker level in uterus. High expression in neural tube and in CNS throughout development. High expression in sensory ganglia and retina from 11 dpc. In the alimentary tract and olfactory epithelium expression was seen from 13 dpc. Strong expression present in liver and kidney, from 11 dpc and 13 dpc respectively, and then expression decreased at later stages of development. Moderate expression in lung from 13 dpc, while it decreases during postnatal life. Strong expression in thymus from 15 dpc onwards, and in spleen from 17 dpc and during early postnatal life, then, the expression decreases.

Interaction

Subunit

Monomer and homodimer. Interacts in vitro with the basal transcription factors GTF2A and TBP, suggesting an autonomous transactivation function. Interacts with NCOA1, CRSP3, RBM14, the histone acetyltransferase proteins EP300 and CREBBP, and with methyltransferase proteins NCOA6IP and PRMT2 (By similarity).
Interacts with RBM39. Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity).
Interacts with ZNF335; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, motif.

TypeIDPosition(s)Description
Region1-932TBP/GTF2A-binding region
Region1-1060CREBBP-binding region
Region1-1314NCOA1-binding region
Region181-253Disordered
Compositional bias182-198Polar residues
Compositional bias223-237Polar residues
Compositional bias293-311Polar residues
Region293-548Disordered
Compositional bias329-351Polar residues
Compositional bias384-406Polar residues
Compositional bias417-506Polar residues
Compositional bias527-548Polar residues
Region777-931NCOA6IP-binding region
Motif891-895LXXLL motif 1
Region903-1279Disordered
Compositional bias971-1026Pro residues
Compositional bias1027-1041Polar residues
Compositional bias1099-1216Polar residues
Compositional bias1218-1232Pro residues
Region1313-1358Disordered
Compositional bias1424-1447Polar residues
Region1424-1481Disordered
Motif1495-1499LXXLL motif 2
Region1497-1581Disordered
Compositional bias1540-1581Polar residues
Region1644-2067EP300/CRSP3-binding region
Compositional bias1769-1816Polar residues
Region1769-1822Disordered
Region1840-1911Disordered
Compositional bias1867-1909Polar residues
Region1957-2067Disordered
Compositional bias2007-2021Basic and acidic residues
Compositional bias2043-2057Polar residues

Domain

Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Only motif 1 is essential for the association with nuclear receptors.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9JL19-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    2,067
  • Mass (Da)
    219,663
  • Last updated
    2000-10-01 v1
  • Checksum
    C855F8777167AD48
MVLDDLPNFEDIYTSLCSSTMGDSEVEFDSGLEDDDTKGDSILEDSTIFVAFKGNIDDKDFKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLWILAQSNNQQLRDLGILSVQIEGEGAINLALGQNRSQDVRMNGPVASGNSVRMEAGFPMASGPGLIRMTSPAAVMTPQGGNMSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLPPAHHSMQPVPVNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQTRPLQQHQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTTNQGWKKAPLPSPMQAQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKGLQGGPSRVPTPLQQPHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLSQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTAATPGNSGALQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNINNQQAGSSGVPQVTLGNMQGQPQQGPPSQLMGMHQQIVPSQGQMAQQQGTLNPQNPMILSRAQLMPQGQMMVNAQNQNLGPSPQRMTPPKQMLPQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKAQFNSQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVNNSPSQVMGIQGQVLRPPGPSPHMAQQHTDPVTTANNDVNLSQMMPDVSMQQASMVPPHVQSMQGNSASGSHFSGHGVSFNAPFGGAPNGSQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQNNTNANKPKKKKPPRKKKNCHQDLNTPDNRPTGLEEVDQQSLPGEQGINLDTTGPKLPDFSNRPPGYPTQPVEQRPLPQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQPQSQQQQQQQQMMMMLMMQQDPKSIRLPVSQNVHPPRGPLNPDSQRMPVQQSGNVPVMVGLQGPASVPPSPDKQRMPMSVNTPMGSNSRKMVYQENPQNSSSSPLGEMSSLPEASGSEVPSVAGGPNNMPSHLVVSQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPLPPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTITNPPNFAAPQAHKLDSVVVNSGKQSNPGTTKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTSTTMLQNMELPRNVLVGPTPLANPPLPGSFPNNTGLNPQNPTVPVPAMGTVLEDNKESVNIPQDSDCQNAQGRKEQVNTELKVVPTQEAKMAVPEDQSKKDGQPLDPNKLPSVEENKNLMSPAMREAPTSLSQLLDNSGAPNVTIKPPGLTDLEVTPPVVSGEDLRKASVIPTLQDPPSKEPSTSLSSPHSSEPCSTLARSELSEVSSNAAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSSNTSAALPTHLQSALMSTVVTMPNVGNKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPSTIPATPLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVTPNVPSSSPAPNIQTGRPLVLSSRATPVQLPSPPCTSSPVVAPNPSVQQVKELNPDEASPQTNTSADQSTLPPSQPTTVVSSLLTNSPGSSANRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGPGLEITTPGLMGTEQCSTELDSKTPTPSAPTLLKMTSSPMAPSSTSTGPILPGGALPTSVRSIVTTLVPSELISTAPTTKGNHGGVTSEPLAGGLVEEKVGSHPELLPSIAPSQNLAPKETPATALQGSVARPELEANAAIASGQSCEPKEIVEKSKTLTSRRNSRTEEPTMASESVENGHRKRSSRPASASSSTKDITGAVQSKRRKSK

Q9JL19-2

  • Name
    2
  • Note
    Acts as a dominant negative repressor.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q5XJV5Q5XJV5_MOUSENcoa62069
A2AQM9A2AQM9_MOUSENcoa61516
A2AQN0A2AQN0_MOUSENcoa6519

Features

Showing features for sequence conflict, compositional bias, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict39in Ref. 2; AAH31113
Sequence conflict109in Ref. 2; AAH31113
Compositional bias182-198Polar residues
Sequence conflict194in Ref. 2; AAH31113
Compositional bias223-237Polar residues
Sequence conflict290in Ref. 2; AAH31113
Compositional bias293-311Polar residues
Compositional bias329-351Polar residues
Compositional bias384-406Polar residues
Compositional bias417-506Polar residues
Alternative sequenceVSP_003410458-2067in isoform 2
Compositional bias527-548Polar residues
Compositional bias971-1026Pro residues
Sequence conflict1014in Ref. 3; AAF35973
Compositional bias1027-1041Polar residues
Compositional bias1099-1216Polar residues
Sequence conflict1141-1142in Ref. 3; AAF35973
Compositional bias1218-1232Pro residues
Compositional bias1424-1447Polar residues
Compositional bias1540-1581Polar residues
Compositional bias1769-1816Polar residues
Compositional bias1867-1909Polar residues
Compositional bias2007-2021Basic and acidic residues
Compositional bias2043-2057Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF216186
EMBL· GenBank· DDBJ
AAF35860.1
EMBL· GenBank· DDBJ
mRNA
BC031113
EMBL· GenBank· DDBJ
AAH31113.1
EMBL· GenBank· DDBJ
mRNA
AF135169
EMBL· GenBank· DDBJ
AAF35973.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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