Q9JKY5 · HIP1R_MOUSE

  • Protein
    Huntingtin-interacting protein 1-related protein
  • Gene
    Hip1r
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcell cortex
Cellular Componentclathrin-coated pit
Cellular Componentclathrin-coated vesicle
Cellular Componentclathrin-coated vesicle membrane
Cellular Componentcortical actin cytoskeleton
Cellular Componentcytoskeleton
Cellular Componentcytosol
Cellular Componentdendrite cytoplasm
Cellular Componentdendritic spine
Cellular Componentglutamatergic synapse
Cellular Componentmitochondrion
Cellular Componentneuronal cell body
Cellular Componentperinuclear region of cytoplasm
Cellular Componentpostsynapse
Cellular Componentpostsynaptic density
Cellular Componentruffle membrane
Cellular Componentsynaptic membrane
Molecular Functionactin binding
Molecular Functionactin filament binding
Molecular Functionclathrin adaptor activity
Molecular Functionclathrin binding
Molecular Functionclathrin light chain binding
Molecular Functionphosphatidylinositol binding
Molecular Functionphosphatidylinositol-3,4,5-trisphosphate binding
Molecular Functionphosphatidylinositol-3,4-bisphosphate binding
Molecular Functionphosphatidylinositol-3,5-bisphosphate binding
Molecular Functionphosphatidylinositol-4,5-bisphosphate binding
Molecular Functionprotein heterodimerization activity
Molecular Functionprotein homodimerization activity
Molecular FunctionSH3 domain binding
Biological Processactin filament organization
Biological Processclathrin coat assembly
Biological Processdigestive system development
Biological Processendocytosis
Biological Processmembrane organization
Biological Processnegative regulation of actin filament polymerization
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of Arp2/3 complex-mediated actin nucleation
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of clathrin coat assembly
Biological Processpositive regulation of clathrin-dependent endocytosis
Biological Processpositive regulation of epidermal growth factor receptor signaling pathway
Biological Processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Biological Processpositive regulation of platelet-derived growth factor receptor-beta signaling pathway
Biological Processpostsynapse organization
Biological Processprotein stabilization
Biological Processreceptor-mediated endocytosis
Biological Processregulation of actin cytoskeleton organization
Biological Processregulation of clathrin-dependent endocytosis
Biological Processregulation of gastric acid secretion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Huntingtin-interacting protein 1-related protein
  • Short names
    HIP1-related protein

Gene names

    • Name
      Hip1r

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9JKY5
  • Secondary accessions
    • Q3UJ14

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Hip1 and Hip1r double knockout mice are dwarfed, afflicted with severe vertebral defects and die in early adulthood.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 55 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00000839851-1068

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed. Expressed at lower levels in skeletal muscle and heart. The level of expression does not change appreciably during development.

Gene expression databases

Interaction

Subunit

Homodimer (PubMed:18790740).
Interacts with actin; homodimerization promotes actin binding (PubMed:18790740).
Interacts with CLTB (By similarity).
Interacts with HIP1 (By similarity).
Interacts (via ENTH and I/LWEQ domains) with BCL2L10 (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9JKY5Cttn Q605984EBI-642457, EBI-397955
XENO Q9JKY5Egfr G3V6K62EBI-642457, EBI-27088566
XENO Q9JKY5SH3KBP1 Q96B973EBI-642457, EBI-346595

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, coiled coil, region.

TypeIDPosition(s)Description
Domain23-151ENTH
Coiled coil346-644
Region582-610Disordered
Domain771-1012I/LWEQ
Region867-924Important for actin binding
Region1011-1068Disordered

Domain

Binds F-actin via the talin-like I/LWEQ domain.

Sequence similarities

Belongs to the SLA2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,068
  • Mass (Da)
    119,426
  • Last updated
    2011-07-27 v2
  • Checksum
    992FD4D3FA3F8A6C
MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINSQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLSSSSILSWKFCHVLHKVLRDGHPNVLHDYQRYRSNIREIGDLWGHLRDQYGHLVNIYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLMFKLHSCLPADTLQGHRDRFHEQFHSLKNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEEEEPENLIEISSAPPAGEPVVVADLFDQTFGPPNGSMKDDRDLQIENLKREVETLRAELEKIKMEAQRYISQLKGQVNGLEAELEEQRKQKQKALVDNEQLRHELAQLKALQLEGARNQGLREEAERKASATEARYSKLKEKHSELINTHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQMEQAKRESEMKMEEQSDQLEKLKRELAARAGELARAQEALSRTEQSGSELSSRLDTLNAEKEALSGVVRQREAELLAAQSLVREKEEALSQEQQRSSQEKGELRGQLAEKESQEQGLRQKLLDEQLAVLRSAAAEAEAILQDAVSKLDDPLHLRCTSSPDYLVSRAQAALDSVSGLEQGHTQYLASSEDASALVAALTRFSHLAADTIVNGAATSHLAPTDPADRLMDTCRECGARALELVGQLQDQTVLPRAQPSLMRAPLQGILQLGQDLKPKSLDVRQEELGAMVDKEMAATSAAIEDAVRRIEDMMSQARHESSGVKLEVNERILNSCTDLMKAIRLLVMTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVESADKVVLHMGKYEELIVCSHEIAASTAQLVAASKVKANKNSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERVRLGELRKQHYVLAGGMGTPSEEEPSRPSPAPRSGATKKPPLAQKPSIAPRTDNQLDKKDGVYPAQLVNY

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9Q3C5E9Q3C5_MOUSEHip1r117
F7DCR9F7DCR9_MOUSEHip1r141
A0A0G2JFU3A0A0G2JFU3_MOUSEHip1r165

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict746in Ref. 1; AAF34662

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF221713
EMBL· GenBank· DDBJ
AAF34662.1
EMBL· GenBank· DDBJ
mRNA
AK146663
EMBL· GenBank· DDBJ
BAE27341.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp