Q9JKT5 · TR105_RAT
- ProteinTaste receptor type 2 member 105
- GeneTas2r105
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids309 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Miscellaneous
Several bitter taste receptors are expressed in a single taste receptor cell.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | bitter taste receptor activity | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | taste receptor activity |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTaste receptor type 2 member 105
- Short namesT2R105
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ9JKT5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-9 | Extracellular | ||||
Sequence: MLSAAEGIL | ||||||
Transmembrane | 10-32 | Helical; Name=1 | ||||
Sequence: LSIATVEAGLGVLGNTFIALVNC | ||||||
Topological domain | 33-44 | Cytoplasmic | ||||
Sequence: MDWAKNKKLSKI | ||||||
Transmembrane | 45-67 | Helical; Name=2 | ||||
Sequence: GFLLFGLATSRIFIVWILILDAY | ||||||
Topological domain | 68-86 | Extracellular | ||||
Sequence: AKLFFPGKYLSKSLTEIIS | ||||||
Transmembrane | 87-109 | Helical; Name=3 | ||||
Sequence: CIWMTVNHMTVWFATSLSIFYFL | ||||||
Topological domain | 110-129 | Cytoplasmic | ||||
Sequence: KIANFSHYIFLWLKRRTDKV | ||||||
Transmembrane | 130-149 | Helical; Name=4 | ||||
Sequence: FAFLLWCLLISWAISFSFTV | ||||||
Topological domain | 150-177 | Extracellular | ||||
Sequence: KVMKSNPKNHGNRTSGTHWEKREFTSNY | ||||||
Transmembrane | 178-200 | Helical; Name=5 | ||||
Sequence: VLINIGVISLLIMTLTACFLLII | ||||||
Topological domain | 201-226 | Cytoplasmic | ||||
Sequence: SLWKHSRQMQSNVSGFRDLNTEAHVK | ||||||
Transmembrane | 227-249 | Helical; Name=6 | ||||
Sequence: AIKFLISFIILFILYFIGVAVEI | ||||||
Topological domain | 250-258 | Extracellular | ||||
Sequence: ICMFIPENK | ||||||
Transmembrane | 259-281 | Helical; Name=7 | ||||
Sequence: LLFIFGLTTASVYPCCHSVILIL | ||||||
Topological domain | 282-309 | Cytoplasmic | ||||
Sequence: TNSQLKQAFVKVLEGLKFSENGKDLRAT |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000082360 | 1-309 | Taste receptor type 2 member 105 | |||
Sequence: MLSAAEGILLSIATVEAGLGVLGNTFIALVNCMDWAKNKKLSKIGFLLFGLATSRIFIVWILILDAYAKLFFPGKYLSKSLTEIISCIWMTVNHMTVWFATSLSIFYFLKIANFSHYIFLWLKRRTDKVFAFLLWCLLISWAISFSFTVKVMKSNPKNHGNRTSGTHWEKREFTSNYVLINIGVISLLIMTLTACFLLIISLWKHSRQMQSNVSGFRDLNTEAHVKAIKFLISFIILFILYFIGVAVEIICMFIPENKLLFIFGLTTASVYPCCHSVILILTNSQLKQAFVKVLEGLKFSENGKDLRAT | ||||||
Glycosylation | 161 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae. Expressed in the duodenum, antrum and fundus (part of the stomach).
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length309
- Mass (Da)35,149
- Last updated2000-10-01 v1
- Checksum0FCE43EB9D3F0090
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF227146 EMBL· GenBank· DDBJ | AAF43919.1 EMBL· GenBank· DDBJ | mRNA |