Q9JKT4 · TR105_MOUSE

  • Protein
    Taste receptor type 2 member 105
  • Gene
    Tas2r105
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functionbitter taste receptor activity
Molecular FunctionG protein-coupled receptor activity
Molecular Functiontaste receptor activity
Biological Processsensory perception of bitter taste

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Taste receptor type 2 member 105
  • Short names
    T2R105
  • Alternative names
    • Taste receptor type 2 member 5 (T2R5)
    • Taste receptor type 2 member 9 (T2R9)

Gene names

    • Name
      Tas2r105
    • Synonyms
      Tas2r5, Tas2r9

Organism names

  • Taxonomic identifier
  • Strain
    • 129/SvJ
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9JKT4

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-7Extracellular
Transmembrane8-28Helical; Name=1
Topological domain29-43Cytoplasmic
Transmembrane44-64Helical; Name=2
Topological domain65-87Extracellular
Transmembrane88-108Helical; Name=3
Topological domain109-128Cytoplasmic
Transmembrane129-149Helical; Name=4
Topological domain150-181Extracellular
Transmembrane182-202Helical; Name=5
Topological domain203-233Cytoplasmic
Transmembrane234-254Helical; Name=6
Topological domain255-259Extracellular
Transmembrane260-280Helical; Name=7
Topological domain281-300Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Mice fail to avoid cycloheximide at low concentrations and show a lack of cycloheximide-induced action potentials in a principal nerve innervating taste receptor cells of the tongue.

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant44in strain: BALB/c, C3H/He, CBA/Ca and DBA/2J
Natural variant155in strain: BALB/c, C3H/He, CBA/Ca and DBA/2J
Natural variant294in strain: BALB/c, C3H/He, CBA/Ca and DBA/2J

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 33 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000823591-300Taste receptor type 2 member 105
Glycosylation161N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in gastric and duodenal tissues.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    300
  • Mass (Da)
    34,416
  • Last updated
    2000-10-01 v1
  • Checksum
    92AD449C68FB85EB
MLSAAEGILLSIATVEAGLGVLGNTFIALVNCMDWAKNNKLSMTGFLLIGLATSRIFIVWLLTLDAYAKLFYPSKYFSSSLIEIISYIWMTVNHLTVWFATSLSIFYFLKIANFSDCVFLWLKRRTDKAFVFLLGCLLTSWVISFSFVVKVMKDGKVNHRNRTSEMYWEKRQFTINYVFLNIGVISLFMMTLTACFLLIMSLWRHSRQMQSGVSGFRDLNTEAHVKAIKFLISFIILFVLYFIGVSIEIICIFIPENKLLFIFGFTTASIYPCCHSFILILSNSQLKQAFVKVLQGLKFF

Polymorphism

Variations in Tas2r105 are associated with avoidance of cycloheximide at low concentrations.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF227147
EMBL· GenBank· DDBJ
AAF43920.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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