Q9JKT4 · TR105_MOUSE
- ProteinTaste receptor type 2 member 105
- GeneTas2r105
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids300 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Miscellaneous
Several bitter taste receptors are expressed in a single taste receptor cell.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | bitter taste receptor activity | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | taste receptor activity | |
Biological Process | sensory perception of bitter taste |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTaste receptor type 2 member 105
- Short namesT2R105
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9JKT4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-7 | Extracellular | ||||
Sequence: MLSAAEG | ||||||
Transmembrane | 8-28 | Helical; Name=1 | ||||
Sequence: ILLSIATVEAGLGVLGNTFIA | ||||||
Topological domain | 29-43 | Cytoplasmic | ||||
Sequence: LVNCMDWAKNNKLSM | ||||||
Transmembrane | 44-64 | Helical; Name=2 | ||||
Sequence: TGFLLIGLATSRIFIVWLLTL | ||||||
Topological domain | 65-87 | Extracellular | ||||
Sequence: DAYAKLFYPSKYFSSSLIEIISY | ||||||
Transmembrane | 88-108 | Helical; Name=3 | ||||
Sequence: IWMTVNHLTVWFATSLSIFYF | ||||||
Topological domain | 109-128 | Cytoplasmic | ||||
Sequence: LKIANFSDCVFLWLKRRTDK | ||||||
Transmembrane | 129-149 | Helical; Name=4 | ||||
Sequence: AFVFLLGCLLTSWVISFSFVV | ||||||
Topological domain | 150-181 | Extracellular | ||||
Sequence: KVMKDGKVNHRNRTSEMYWEKRQFTINYVFLN | ||||||
Transmembrane | 182-202 | Helical; Name=5 | ||||
Sequence: IGVISLFMMTLTACFLLIMSL | ||||||
Topological domain | 203-233 | Cytoplasmic | ||||
Sequence: WRHSRQMQSGVSGFRDLNTEAHVKAIKFLIS | ||||||
Transmembrane | 234-254 | Helical; Name=6 | ||||
Sequence: FIILFVLYFIGVSIEIICIFI | ||||||
Topological domain | 255-259 | Extracellular | ||||
Sequence: PENKL | ||||||
Transmembrane | 260-280 | Helical; Name=7 | ||||
Sequence: LFIFGFTTASIYPCCHSFILI | ||||||
Topological domain | 281-300 | Cytoplasmic | ||||
Sequence: LSNSQLKQAFVKVLQGLKFF |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mice fail to avoid cycloheximide at low concentrations and show a lack of cycloheximide-induced action potentials in a principal nerve innervating taste receptor cells of the tongue.
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 44 | in strain: BALB/c, C3H/He, CBA/Ca and DBA/2J | ||||
Sequence: T → I | ||||||
Natural variant | 155 | in strain: BALB/c, C3H/He, CBA/Ca and DBA/2J | ||||
Sequence: G → D | ||||||
Natural variant | 294 | in strain: BALB/c, C3H/He, CBA/Ca and DBA/2J | ||||
Sequence: L → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 33 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000082359 | 1-300 | Taste receptor type 2 member 105 | |||
Sequence: MLSAAEGILLSIATVEAGLGVLGNTFIALVNCMDWAKNNKLSMTGFLLIGLATSRIFIVWLLTLDAYAKLFYPSKYFSSSLIEIISYIWMTVNHLTVWFATSLSIFYFLKIANFSDCVFLWLKRRTDKAFVFLLGCLLTSWVISFSFVVKVMKDGKVNHRNRTSEMYWEKRQFTINYVFLNIGVISLFMMTLTACFLLIMSLWRHSRQMQSGVSGFRDLNTEAHVKAIKFLISFIILFVLYFIGVSIEIICIFIPENKLLFIFGFTTASIYPCCHSFILILSNSQLKQAFVKVLQGLKFF | ||||||
Glycosylation | 161 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in gastric and duodenal tissues.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length300
- Mass (Da)34,416
- Last updated2000-10-01 v1
- Checksum92AD449C68FB85EB
Polymorphism
Variations in Tas2r105 are associated with avoidance of cycloheximide at low concentrations.
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF227147 EMBL· GenBank· DDBJ | AAF43920.1 EMBL· GenBank· DDBJ | Genomic DNA |