Q9JKP5 · MBNL1_MOUSE
- ProteinMuscleblind-like protein 1
- GeneMbnl1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids341 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs (By similarity).
Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (By similarity).
Regulates NCOR2 alternative splicing (By similarity).
Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (By similarity).
Regulates NCOR2 alternative splicing (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoplasmic stress granule | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | double-stranded RNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | regulatory region RNA binding | |
Molecular Function | RNA binding | |
Biological Process | alternative mRNA splicing, via spliceosome | |
Biological Process | embryonic limb morphogenesis | |
Biological Process | in utero embryonic development | |
Biological Process | mRNA splice site recognition | |
Biological Process | myoblast differentiation | |
Biological Process | nervous system development | |
Biological Process | regulation of alternative mRNA splicing, via spliceosome | |
Biological Process | regulation of RNA splicing | |
Biological Process | RNA splicing | |
Biological Process | skeletal muscle tissue development |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMuscleblind-like protein 1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9JKP5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localized with DDX1, TIAL1 and YBX1 in stress granules upon stress. Localized in the cytoplasm of multinucleated myotubes.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000089179 | 1-341 | Muscleblind-like protein 1 | |||
Sequence: MAVSVTPIRDTKWLTLEVCREFQRGTCSRPDTECKFAHPSKSCQVENGRVIACFDSLKGRCSRENCKYLHPPPHLKTQLEINGRNNLIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATSASAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKLMRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATAAAMGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPGSILCMTPATSVDTHNICRTSD | ||||||
Modified residue | 6 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in cardiac and skeletal muscle. Weakly expressed in heart and eye (at protein level).
Gene expression databases
Interaction
Subunit
Interacts with DDX1 and YBX1. Interacts with HNRNPH1; the interaction in RNA-independent (By similarity).
Interacts with RBPMS; the interaction allows cooperative assembly of RNA-bound stable cell-specific alternative splicing regulatory complexes (By similarity).
Interacts with RBPMS; the interaction allows cooperative assembly of RNA-bound stable cell-specific alternative splicing regulatory complexes (By similarity).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 13-41 | C3H1-type 1 | ||||
Sequence: WLTLEVCREFQRGTCSRPDTECKFAHPSK | ||||||
Zinc finger | 47-73 | C3H1-type 2 | ||||
Sequence: NGRVIACFDSLKGRCSRENCKYLHPPP | ||||||
Zinc finger | 178-206 | C3H1-type 3 | ||||
Sequence: TDRLEVCREYQRGNCNRGENDCRFAHPAD | ||||||
Zinc finger | 214-240 | C3H1-type 4 | ||||
Sequence: DNTVTVCMDYIKGRCSREKCKYFHPPA |
Sequence similarities
Belongs to the muscleblind family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length341
- Mass (Da)36,976
- Last updated2000-10-01 v1
- Checksum8E008DB5C7EF8AB9
Computationally mapped potential isoform sequences
There are 13 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q3U570 | Q3U570_MOUSE | Mbnl1 | 254 | ||
Q3U581 | Q3U581_MOUSE | Mbnl1 | 289 | ||
A0A0A6YVV8 | A0A0A6YVV8_MOUSE | Mbnl1 | 387 | ||
A0A0A6YWG1 | A0A0A6YWG1_MOUSE | Mbnl1 | 257 | ||
A0A0A6YWB0 | A0A0A6YWB0_MOUSE | Mbnl1 | 347 | ||
A0A0A6YWJ5 | A0A0A6YWJ5_MOUSE | Mbnl1 | 209 | ||
A0A0A6YX59 | A0A0A6YX59_MOUSE | Mbnl1 | 18 | ||
A0A0A6YXG7 | A0A0A6YXG7_MOUSE | Mbnl1 | 23 | ||
A0A0A6YXE3 | A0A0A6YXE3_MOUSE | Mbnl1 | 302 | ||
A0A0A6YXQ4 | A0A0A6YXQ4_MOUSE | Mbnl1 | 302 | ||
A0A0A6YXP3 | A0A0A6YXP3_MOUSE | Mbnl1 | 182 | ||
A0A0A6YXL7 | A0A0A6YXL7_MOUSE | Mbnl1 | 192 | ||
G3X9Q0 | G3X9Q0_MOUSE | Mbnl1 | 381 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF231110 EMBL· GenBank· DDBJ | AAF72159.1 EMBL· GenBank· DDBJ | mRNA |