Q9JJZ5 · EGFL6_MOUSE

  • Protein
    Epidermal growth factor-like protein 6
  • Gene
    Egfl6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasement membrane
Cellular Componentextracellular matrix
Cellular Componentextracellular region
Cellular Componentmembrane
Molecular Functioncalcium ion binding
Biological Processcell adhesion
Biological Processcell differentiation
Biological Processextracellular matrix organization
Biological Processpositive regulation of cell-substrate adhesion

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Epidermal growth factor-like protein 6
  • Short names
    EGF-like protein 6
  • Alternative names
    • MAM and EGF domains-containing gene protein
    • Protein W80

Gene names

    • Name
      Egfl6
    • Synonyms
      Maeg

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9JJZ5
  • Secondary accessions
    • Q8BPM8

Proteomes

Organism-specific databases

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis362Loss of adhesive activity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 47 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000029581219-550Epidermal growth factor-like protein 6
Disulfide bond59↔72
Disulfide bond63↔78
Disulfide bond80↔89
Disulfide bond96↔107
Disulfide bond103↔116
Disulfide bond118↔130
Disulfide bond176↔189
Disulfide bond183↔198
Disulfide bond221↔234
Disulfide bond228↔243
Disulfide bond245↔256
Glycosylation394N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed at basement membrane of pelage follicles (at protein level).

Developmental stage

Detected in early lateral dermatome and in all dermatome derivatives. Expressed at the basement membrane of embryonic skin and developing hair follicles. At 16.5 dpc, present in lung epithelium, and developing oral and tooth germ epithelia (at protein level).

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Domain55-90EGF-like 1
Domain92-131EGF-like 2; calcium-binding
Domain135-171EGF-like 3
Domain172-210EGF-like 4; calcium-binding
Domain217-257EGF-like 5; calcium-binding
Region295-354Disordered
Compositional bias321-354Basic and acidic residues
Coiled coil327-357
Domain397-543MAM

Sequence similarities

Belongs to the nephronectin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    550
  • Mass (Da)
    61,520
  • Last updated
    2000-10-01 v1
  • Checksum
    DEF936325C9F31B3
MQPPWGLALPLLLPWVTGGVGTSPWDYGLSALAHQPGVCQYGTKMACCYGWKRNNKGVCEAMCEPRCKFGECVGPNKCRCFPGYTGKTCTQDVNECGVKPRPCQHRCVNTHGSYKCFCLSGHMLLPDATCSNSRTCARLNCQYGCEDTEEGPRCVCPSSGLRLGPNGRVCLDIDECASSKAVCPSNRRCVNTFGSYYCKCHIGFELKYIGRRYDCVDINECALNTHPCSPHANCLNTRGSFKCKCKQGYRGNGLQCSVIPEHSVKEILTAPGTIKDRIKKLLAHKRTMKKKVKLKMVTPRPASTRVPKVNLPYSSEEGVSRGRNYDGEQKKKEEGKRERLEEEKGEKTLRNEVEQERTLRGDVFSPKVNEAEDLDLVYVQRKELNSKLKHKDLNISVDCSFDLGVCDWKQDREDDFDWHPADRDNDVGYYMAVPALAGHKKNIGRLKLLLPNLTPQSNFCLLFDYRLAGDKVGKLRVFVKNSNNALAWEETKNEDGRWRTGKIQLYQGIDTTKSVIFEAERGKGKTGEIAVDGVLLVSGLCPDDFLSVEG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias321-354Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ245672
EMBL· GenBank· DDBJ
CAB92138.1
EMBL· GenBank· DDBJ
mRNA
AL672174
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC117702
EMBL· GenBank· DDBJ
AAI17703.1
EMBL· GenBank· DDBJ
mRNA
AK053738
EMBL· GenBank· DDBJ
BAC35499.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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