Q9JJM7 · GP1BB_RAT
- ProteinPlatelet glycoprotein Ib beta chain
- GeneGp1bb
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids206 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.
Miscellaneous
Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | glycoprotein Ib-IX-V complex | |
Molecular Function | identical protein binding | |
Biological Process | blood coagulation | |
Biological Process | blood coagulation, intrinsic pathway | |
Biological Process | cell adhesion | |
Biological Process | megakaryocyte development | |
Biological Process | positive regulation of platelet activation | |
Biological Process | release of sequestered calcium ion into cytosol |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePlatelet glycoprotein Ib beta chain
- Short namesGP-Ib beta; GPIb-beta; GPIbB
- CD Antigen Name
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ9JJM7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 27-150 | Extracellular | ||||
Sequence: PAPCRCSETRVDCGRRGLTWASLPAAFPPDTTELVLTDNNLTALPPGLLDTLPALRRVHLGANPWRCDCRLLPLRAWLAGRPEREFYRDLRCVAPLALRGRLLPYVAEDELRAACAPGLLCWGA | ||||||
Transmembrane | 151-171 | Helical | ||||
Sequence: LVAQLALLVLGLLHALLLALL | ||||||
Topological domain | 172-206 | Cytoplasmic | ||||
Sequence: LSRLRRLRAQARARSTREFSLTAPLVAESAGGGAS |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, disulfide bond, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MGSRPRGALSLLLLLLAPPSRPASGC | ||||||
Disulfide bond | 26↔32 | |||||
Sequence: CPAPCRC | ||||||
Chain | PRO_0000326528 | 27-206 | Platelet glycoprotein Ib beta chain | |||
Sequence: PAPCRCSETRVDCGRRGLTWASLPAAFPPDTTELVLTDNNLTALPPGLLDTLPALRRVHLGANPWRCDCRLLPLRAWLAGRPEREFYRDLRCVAPLALRGRLLPYVAEDELRAACAPGLLCWGALVAQLALLVLGLLHALLLALLLSRLRRLRAQARARSTREFSLTAPLVAESAGGGAS | ||||||
Disulfide bond | 30↔39 | |||||
Sequence: CRCSETRVDC | ||||||
Disulfide bond | 93↔118 | |||||
Sequence: CDCRLLPLRAWLAGRPEREFYRDLRC | ||||||
Disulfide bond | 95↔141 | |||||
Sequence: CRLLPLRAWLAGRPEREFYRDLRCVAPLALRGRLLPYVAEDELRAAC | ||||||
Disulfide bond | 147 | Interchain (with C-608 or C-609 in GP1BA) | ||||
Sequence: C | ||||||
Modified residue | 186 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 191 | Phosphoserine; by PKA | ||||
Sequence: S | ||||||
Modified residue | 193 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 200 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 27-55 | LRRNT | ||||
Sequence: PAPCRCSETRVDCGRRGLTWASLPAAFPP | ||||||
Repeat | 60-83 | LRR | ||||
Sequence: LVLTDNNLTALPPGLLDTLPALRR | ||||||
Domain | 89-143 | LRRCT | ||||
Sequence: NPWRCDCRLLPLRAWLAGRPEREFYRDLRCVAPLALRGRLLPYVAEDELRAACAP |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length206
- Mass (Da)22,175
- Last updated2000-10-01 v1
- Checksum38ECE6E99DEF22B8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB027146 EMBL· GenBank· DDBJ | BAA98053.1 EMBL· GenBank· DDBJ | mRNA |