O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development.Neupane S., Berardinelli S.J., Cameron D.C., Grady R.C., Komatsu D.E., Percival C.J., Takeuchi M., Ito A., Liu T.W.[...], Holdener B.C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCMatrix Biol 107:77-96 (2022)Mapped to99+
The role of the histone methyltransferase SET domain bifurcated 1 during palatal development.Kano S., Higashihori N., Thiha P., Takechi M., Iseki S., Moriyama K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCBiochem Biophys Res Commun 598:74-80 (2022)Mapped to28
FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development.Meuser M., Deuper L., Rudat C., Aydogdu N., Thiesler H., Zarnovican P., Hildebrandt H., Trowe M.O., Kispert A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCDevelopment 149:dev200021-dev200021 (2022)Mapped to99+
mTOR deletion in neural crest cells disrupts cardiac outflow tract remodeling and causes a spectrum of cardiac defects through the mTORC1 pathway.Nie X., Ricupero C.L., Jiao K., Yang P., Mao J.J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCDev Biol 477:241-250 (2021)Mapped to99+
Loss of Smad4 in the scleraxis cell lineage results in postnatal joint contracture.Schlesinger S.Y., Seo S., Pryce B.A., Tufa S.F., Keene D.R., Huang A.H., Schweitzer R.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCDev Biol 470:108-120 (2021)Mapped to46
Mutation in Bmpr1b Leads to Optic Disc Coloboma and Ventral Retinal Gliosis in Mice.German Mouse Clinic ConsortiumYan X., Atorf J., Ramos D., Thiele F., Weber S., Dalke C., Sun M., Puk O., Michel D.[...], Graw J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCInvest Ophthalmol Vis Sci 61:44-44 (2020)Mapped to54
Ablation of Hepatocyte Smad1, Smad5, and Smad8 Causes Severe Tissue Iron Loading and Liver Fibrosis in Mice.Wang C.Y., Xiao X., Bayer A., Xu Y., Dev S., Canali S., Nair A.V., Masia R., Babitt J.L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCHepatology 70:1986-2002 (2019)Mapped to10
Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.Dupays L., Towers N., Wood S., David A., Stuckey D.J., Mohun T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCPLoS One 14:e0212992-e0212992 (2019)Mapped to50
Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe Scoliosis in Mice with Deficiency of c-Jun NH2-Terminal Kinases 1 and 2.Ulici V., Kelley K.L., Longobardi L., McNulty M.A., Livingston E.W., Bateman T.A., Seguin C.A., Louer C.R., Loeser R.F.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCAm J Pathol 189:868-885 (2019)Mapped to75
MicroRNAs control eyelid development through regulating Wnt signaling.Nagai T., Trakanant S., Kawasaki M., Kawasaki K., Yamada Y., Watanabe M., Blackburn J., Otsuka-Tanaka Y., Hishinuma M.[...], Ohazama A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCDev Dyn 248:201-210 (2019)Mapped to45
Conditional deletion of Bmp2 in cranial neural crest cells recapitulates Pierre Robin sequence in mice.Chen Y., Wang Z., Chen Y., Zhang Y.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCCell Tissue Res 376:199-210 (2019)Mapped to52
Deletion of Lrp4 increases the incidence of microphthalmia.Tanahashi H., Suzuki T.View abstractCategoriesPhenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCBiochem Biophys Res Commun 506:478-484 (2018)Mapped to99+
Myocardial beta-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation.Wang Y., Lu P., Wu B., Riascos-Bernal D.F., Sibinga N.E.S., Valenta T., Basler K., Zhou B.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCJ Mol Cell Cardiol 123:150-158 (2018)Mapped to99+
Protein Arginine Methyltransferase PRMT1 Is Essential for Palatogenesis.Gou Y., Li J., Jackson-Weaver O., Wu J., Zhang T., Gupta R., Cho I., Ho T.V., Chen Y.[...], Xu J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCJ Dent Res 97:1510-1518 (2018)Mapped to61
Anti-osteogenic function of a LIM-homeodomain transcription factor LMX1B is essential to early patterning of the calvaria.Cesario J.M., Landin Malt A., Chung J.U., Khairallah M.P., Dasgupta K., Asam K., Deacon L.J., Choi V., Almaidhan A.A.[...], Jeong J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCDev Biol 443:103-116 (2018)Mapped to99+
Cooperation of BMP and IHH signaling in interdigital cell fate determination.Murgai A., Altmeyer S., Wiegand S., Tylzanowski P., Stricker S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCPLoS One 13:e0197535-e0197535 (2018)Mapped to83
The Role of Bmp2 in the Maturation and Maintenance of the Murine Knee Joint.Gamer L.W., Pregizer S., Gamer J., Feigenson M., Ionescu A., Li Q., Han L., Rosen V.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCJ Bone Miner Res 33:1708-1717 (2018)Mapped to63
Expression of ILK in renal stroma is essential for multiple aspects of renal development.Gong X., Guo X., Huang R., Liao H., Zhang Q., Yan J., Luo L., Zhang Q., Qiu A.[...], Liang X.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCAm J Physiol Renal Physiol 315:F374-F385 (2018)Mapped to67
Precise spatial restriction of BMP signaling in developing joints is perturbed upon loss of embryo movement.Singh P.N.P., Shea C.A., Sonker S.K., Rolfe R.A., Ray A., Kumar S., Gupta P., Murphy P., Bandyopadhyay A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCDevelopment 145:dev153460-dev153460 (2018)Mapped to38
Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death.Liu X., Hayano S., Pan H., Inagaki M., Ninomiya-Tsuji J., Sun H., Mishina Y.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCGenesis 56:e23093-e23093 (2018)Mapped to55
BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells.Jovanovic V.M., Salti A., Tilleman H., Zega K., Jukic M.M., Zou H., Friedel R.H., Prakash N., Blaess S.[...], Brodski C.View abstractCategoriesFunction, Expression, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCJ. Neurosci. 38:1662-1676 (2018)Cited in2Mapped to99+
Cnn3 regulates neural tube morphogenesis and neuronal stem cell properties.Junghans D., Herzog S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCFEBS J 285:325-338 (2018)Mapped to36
Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a.Ching S.T., Infante C.R., Du W., Sharir A., Park S., Menke D.B., Klein O.D.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCHum Mol Genet 27:107-119 (2018)Mapped to20
Modulating Wnt Signaling Rescues Palate Morphogenesis in Pax9 Mutant Mice.Li C., Lan Y., Krumlauf R., Jiang R.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCJ Dent Res 96:1273-1281 (2017)Mapped to32
BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development.Pan H., Zhang H., Abraham P., Komatsu Y., Lyons K., Kaartinen V., Mishina Y.View abstractCategoriesPhenotypes & VariantsSourceMGI: 1859993PubMedEurope PMCDev Biol 429:260-270 (2017)Mapped to32