Q9JI44 · DMAP1_MOUSE
- ProteinDNA methyltransferase 1-associated protein 1
- GeneDmap1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids468 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | NuA4 histone acetyltransferase complex | |
Cellular Component | nucleosome | |
Cellular Component | nucleus | |
Cellular Component | replication fork | |
Cellular Component | Swr1 complex | |
Molecular Function | RNA polymerase II-specific DNA-binding transcription factor binding | |
Molecular Function | transcription corepressor activity | |
Biological Process | chromatin remodeling | |
Biological Process | DNA repair | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | positive regulation of double-strand break repair via homologous recombination | |
Biological Process | positive regulation of protein import into nucleus | |
Biological Process | regulation of apoptotic process | |
Biological Process | regulation of cell cycle | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | regulation of double-strand break repair | |
Biological Process | response to ethanol |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameDNA methyltransferase 1-associated protein 1
- Short namesDNMAP1; DNMT1-associated protein 1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9JI44
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, cross-link, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000079936 | 1-468 | DNA methyltransferase 1-associated protein 1 | |||
Sequence: MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYALLYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEEGKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQVAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAEKPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEELVHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGAPAAAAVGPTPASAEPTVSESGLGLDPTKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP | ||||||
Cross-link | 27 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Cross-link | 214 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 446 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 449 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. DMAP1 also forms a complex with DNMT1 and HDAC2. Throughout S phase it interacts directly with the N-terminus of DNMT1, which serves to recruit DMAP1 to replication foci. DMAP1 interacts with ING1, a component of the mSIN3A transcription repressor complex, although this interaction is not required for recruitment of ING1 to heterochromatin. Interacts directly with the transcriptional corepressor TSG101. Interacts with URI1 (By similarity).
Interacts with the pro-apoptotic protein DAXX
Interacts with the pro-apoptotic protein DAXX
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-48 | Disordered | ||||
Sequence: MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFK | ||||||
Compositional bias | 29-48 | Basic and acidic residues | ||||
Sequence: DIINPDKKKSKKSSETLTFK | ||||||
Domain | 149-199 | SANT | ||||
Sequence: DDAWTKAETDHLFDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKERYYHIC | ||||||
Coiled coil | 225-275 | |||||
Sequence: RRKEQLERLYNRTPEQVAEEEYLLQELRKIEARKKEREKRSQDLQKLITAA | ||||||
Region | 258-305 | Disordered | ||||
Sequence: KKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAEKPAVP | ||||||
Compositional bias | 279-304 | Basic and acidic residues | ||||
Sequence: AEQRRTERKAPKKKLPQKKEAEKPAV | ||||||
Region | 411-468 | Disordered | ||||
Sequence: AVGPTPASAEPTVSESGLGLDPTKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9JI44-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length468
- Mass (Da)53,130
- Last updated2000-10-01 v1
- ChecksumCDDADF2165801C9B
Q9JI44-2
- Name2
- NoteMay be due to intron retention.
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 29-48 | Basic and acidic residues | ||||
Sequence: DIINPDKKKSKKSSETLTFK | ||||||
Alternative sequence | VSP_003850 | 242-323 | in isoform 2 | |||
Sequence: AEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAEKPAVPETAGIKFPDFKSAGVTLR → ITSSTPPSTAQLSLPPGPFTSSPFLWSLFLPSLQESPYLWSLIDNLVSRQLPSHLLPHSPHTHGSISCFAGGRGGVPPTGAA | ||||||
Compositional bias | 279-304 | Basic and acidic residues | ||||
Sequence: AEQRRTERKAPKKKLPQKKEAEKPAV | ||||||
Alternative sequence | VSP_003851 | 324-468 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF265229 EMBL· GenBank· DDBJ | AAF87080.1 EMBL· GenBank· DDBJ | mRNA | ||
AF438610 EMBL· GenBank· DDBJ | AAL31640.1 EMBL· GenBank· DDBJ | mRNA | ||
AK005270 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
AK012055 EMBL· GenBank· DDBJ | BAB27996.3 EMBL· GenBank· DDBJ | mRNA | ||
BC002321 EMBL· GenBank· DDBJ | AAH02321.1 EMBL· GenBank· DDBJ | mRNA | ||
BC045160 EMBL· GenBank· DDBJ | AAH45160.1 EMBL· GenBank· DDBJ | mRNA |