Q9JHL0 · NTAL_MOUSE

  • Protein
    Linker for activation of T-cells family member 2
  • Gene
    Lat2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane raft
Cellular Componentplasma membrane
Molecular FunctionSH2 domain binding
Biological Processadaptive immune response
Biological ProcessB cell activation
Biological ProcessB cell receptor signaling pathway
Biological Processcalcium-mediated signaling
Biological Processintracellular signal transduction
Biological Processmast cell degranulation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Linker for activation of T-cells family member 2
  • Alternative names
    • Linker for activation of B-cells
    • Membrane-associated adapter molecule
    • Non-T-cell activation linker
    • Williams-Beuren syndrome chromosomal region 15 protein homolog

Gene names

    • Name
      Lat2
    • Synonyms
      Lab, Ntal, Wbscr15, Wbscr5

Organism names

  • Taxonomic identifier
  • Strains
    • 129
    • C57BL/6J
    • 129/SvJ
    • 129/Sv
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9JHL0
  • Secondary accessions
    • Q3UYF6
    • Q9JJ29

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type III membrane protein
Note: Present in lipid rafts.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-6Extracellular
Transmembrane7-27Helical; Signal-anchor for type III membrane protein
Topological domain28-203Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Mice exhibit normal T-cell, B-cell and mast cell development and normal humoral response, but have hyperresponsive mast cells.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 17 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, lipidation, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000833351-203Linker for activation of T-cells family member 2
Lipidation26S-palmitoyl cysteine
Lipidation29S-palmitoyl cysteine
Modified residue59Phosphotyrosine
Modified residue60Phosphoserine
Modified residue95Phosphoserine
Modified residue139Phosphotyrosine
Modified residue160Phosphotyrosine
Modified residue192Phosphotyrosine

Post-translational modification

Phosphorylated on tyrosines following cross-linking of BCR in B-cells, high affinity IgG receptor (FCGR1) in myeloid cells, or high affinity IgE receptor (FCER1) in mast cells; which induces the recruitment of GRB2.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Strongly expressed in testis. Expressed in heart, spleen and lung. Present in B-cells and mast cells (at protein level).

Developmental stage

Hardly expressed in pro-B and pre-B cells. Moderately expressed in immature B-cells, mature B-cells and plasma cells. Highly expressed in transitional B-cells.

Gene expression databases

Interaction

Subunit

When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region171-203Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9JHL0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    203
  • Mass (Da)
    22,876
  • Last updated
    2000-10-01 v1
  • Checksum
    1B21A87D8FBAE097
MSAELELLWPVSGLLLLLLGATAWLCVHCSRPGVKRNEKIYEQRNRQENAQSSAAAQTYSLARQVWPGPQMDTAPNKSFERKNKMLFSHLEGPESPRYQNFYKGSNQEPDAAYVDPIPTNYYNWGCFQKPSEDDDSNSYENVLVCKPSTPESGVEDFEDYQNSVSIHQWRESKRTMGAPMSLSGSPDEEPDYVNGDVAAAENI

Q9JHL0-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0J9YV28A0A0J9YV28_MOUSELat2101
A0A0J9YVD5A0A0J9YVD5_MOUSELat2115
A0A0J9YU43A0A0J9YU43_MOUSELat2119

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_01664692-103in isoform 2
Sequence conflict114in Ref. 5; BAE22256

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF257136
EMBL· GenBank· DDBJ
AAF91353.1
EMBL· GenBank· DDBJ
mRNA
AF139987
EMBL· GenBank· DDBJ
AAF75558.1
EMBL· GenBank· DDBJ
Genomic DNA
AF139987
EMBL· GenBank· DDBJ
AAF75559.1
EMBL· GenBank· DDBJ
Genomic DNA
AY190024
EMBL· GenBank· DDBJ
AAO63156.1
EMBL· GenBank· DDBJ
mRNA
AF289664
EMBL· GenBank· DDBJ
AAF99331.1
EMBL· GenBank· DDBJ
Genomic DNA
AK134721
EMBL· GenBank· DDBJ
BAE22256.1
EMBL· GenBank· DDBJ
mRNA
AK138953
EMBL· GenBank· DDBJ
BAE23833.1
EMBL· GenBank· DDBJ
mRNA
AK143533
EMBL· GenBank· DDBJ
BAE25422.1
EMBL· GenBank· DDBJ
mRNA
AK162321
EMBL· GenBank· DDBJ
BAE36852.1
EMBL· GenBank· DDBJ
mRNA
BC005804
EMBL· GenBank· DDBJ
AAH05804.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp