Q9JHL0 · NTAL_MOUSE
- ProteinLinker for activation of T-cells family member 2
- GeneLat2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids203 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane raft | |
Cellular Component | plasma membrane | |
Molecular Function | SH2 domain binding | |
Biological Process | adaptive immune response | |
Biological Process | B cell activation | |
Biological Process | B cell receptor signaling pathway | |
Biological Process | calcium-mediated signaling | |
Biological Process | intracellular signal transduction | |
Biological Process | mast cell degranulation |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLinker for activation of T-cells family member 2
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9JHL0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type III membrane protein
Note: Present in lipid rafts.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-6 | Extracellular | ||||
Sequence: MSAELE | ||||||
Transmembrane | 7-27 | Helical; Signal-anchor for type III membrane protein | ||||
Sequence: LLWPVSGLLLLLLGATAWLCV | ||||||
Topological domain | 28-203 | Cytoplasmic | ||||
Sequence: HCSRPGVKRNEKIYEQRNRQENAQSSAAAQTYSLARQVWPGPQMDTAPNKSFERKNKMLFSHLEGPESPRYQNFYKGSNQEPDAAYVDPIPTNYYNWGCFQKPSEDDDSNSYENVLVCKPSTPESGVEDFEDYQNSVSIHQWRESKRTMGAPMSLSGSPDEEPDYVNGDVAAAENI |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mice exhibit normal T-cell, B-cell and mast cell development and normal humoral response, but have hyperresponsive mast cells.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 17 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, lipidation, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000083335 | 1-203 | Linker for activation of T-cells family member 2 | |||
Sequence: MSAELELLWPVSGLLLLLLGATAWLCVHCSRPGVKRNEKIYEQRNRQENAQSSAAAQTYSLARQVWPGPQMDTAPNKSFERKNKMLFSHLEGPESPRYQNFYKGSNQEPDAAYVDPIPTNYYNWGCFQKPSEDDDSNSYENVLVCKPSTPESGVEDFEDYQNSVSIHQWRESKRTMGAPMSLSGSPDEEPDYVNGDVAAAENI | ||||||
Lipidation | 26 | S-palmitoyl cysteine | ||||
Sequence: C | ||||||
Lipidation | 29 | S-palmitoyl cysteine | ||||
Sequence: C | ||||||
Modified residue | 59 | Phosphotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 60 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 95 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 139 | Phosphotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 160 | Phosphotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 192 | Phosphotyrosine | ||||
Sequence: Y |
Post-translational modification
Phosphorylated on tyrosines following cross-linking of BCR in B-cells, high affinity IgG receptor (FCGR1) in myeloid cells, or high affinity IgE receptor (FCER1) in mast cells; which induces the recruitment of GRB2.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Strongly expressed in testis. Expressed in heart, spleen and lung. Present in B-cells and mast cells (at protein level).
Developmental stage
Hardly expressed in pro-B and pre-B cells. Moderately expressed in immature B-cells, mature B-cells and plasma cells. Highly expressed in transitional B-cells.
Gene expression databases
Structure
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9JHL0-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length203
- Mass (Da)22,876
- Last updated2000-10-01 v1
- Checksum1B21A87D8FBAE097
Q9JHL0-2
- Name2
- Differences from canonical
- 92-103: Missing
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0J9YV28 | A0A0J9YV28_MOUSE | Lat2 | 101 | ||
A0A0J9YVD5 | A0A0J9YVD5_MOUSE | Lat2 | 115 | ||
A0A0J9YU43 | A0A0J9YU43_MOUSE | Lat2 | 119 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_016646 | 92-103 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 114 | in Ref. 5; BAE22256 | ||||
Sequence: V → E |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF257136 EMBL· GenBank· DDBJ | AAF91353.1 EMBL· GenBank· DDBJ | mRNA | ||
AF139987 EMBL· GenBank· DDBJ | AAF75558.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF139987 EMBL· GenBank· DDBJ | AAF75559.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY190024 EMBL· GenBank· DDBJ | AAO63156.1 EMBL· GenBank· DDBJ | mRNA | ||
AF289664 EMBL· GenBank· DDBJ | AAF99331.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK134721 EMBL· GenBank· DDBJ | BAE22256.1 EMBL· GenBank· DDBJ | mRNA | ||
AK138953 EMBL· GenBank· DDBJ | BAE23833.1 EMBL· GenBank· DDBJ | mRNA | ||
AK143533 EMBL· GenBank· DDBJ | BAE25422.1 EMBL· GenBank· DDBJ | mRNA | ||
AK162321 EMBL· GenBank· DDBJ | BAE36852.1 EMBL· GenBank· DDBJ | mRNA | ||
BC005804 EMBL· GenBank· DDBJ | AAH05804.1 EMBL· GenBank· DDBJ | mRNA |