Q9JHI0 · MMP19_MOUSE
- ProteinMatrix metalloproteinase-19
- GeneMmp19
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids527 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis (By similarity).
Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin (By similarity).
Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin (By similarity).
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 86 | Zn2+ (UniProtKB | ChEBI); catalytic; in inhibited form | ||||
Sequence: C | ||||||
Binding site | 213 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Active site | 214 | |||||
Sequence: E | ||||||
Binding site | 217 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 223 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular matrix | |
Cellular Component | extracellular region | |
Cellular Component | extracellular space | |
Cellular Component | plasma membrane | |
Cellular Component | side of membrane | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | angiogenesis | |
Biological Process | cell differentiation | |
Biological Process | collagen catabolic process | |
Biological Process | extracellular matrix organization | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameMatrix metalloproteinase-19
- EC number
- Short namesMMP-19
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9JHI0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, propeptide, chain, glycosylation, disulfide bond, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MDWQQLWLAFLLPMTVSG | ||||||
Propeptide | PRO_0000028828 | 19-98 | ||||
Sequence: RALGPTEKEAVLDYLLQYGYLQKPLEGADDFRLEDITEALRTFQEASGLPISGQMDDATRARMKQPRCGLEDPFNQKSLK | ||||||
Chain | PRO_0000028829 | 99-512 | Matrix metalloproteinase-19 | |||
Sequence: YLLLGHWRKKNLTFRIFNVPSTLSLPRVRAALHQAFKYWSSVAPLTFREVKAGWADIRLSFHGRQSLYCSNTFDGPGKVLAHADIPELGSIHFDKDELWTEGTYQGVNLRIIAAHEVGHALGLGHSRYTQALMAPVYAGYQPFFKLHPDDVAGIQALYGKRSPETRDEEEETEMLTVSPVTAKPGPMPNPCSGEVDAMVLGPRGKTYAFKGDYVWTVTDSGPGPLFQISALWEGLPGNLDAAVYSPRTRRTHFFKGNKVWRYVDFKMSPGFPMKFNRVEPNLDAALYWPVNQKVFLFKGSGYWQWDELARTDLSRYPKPIKELFTGVPDRPSAAMSWQDGQVYFFKGKEYWRLNQQLRVAKGYPRNTTHWMHCGSQTPDTNSSTGDVTPSTTDTVLGTTPSTMGSTLDIPSATD | ||||||
Glycosylation | 109 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 289↔471 | |||||
Sequence: CSGEVDAMVLGPRGKTYAFKGDYVWTVTDSGPGPLFQISALWEGLPGNLDAAVYSPRTRRTHFFKGNKVWRYVDFKMSPGFPMKFNRVEPNLDAALYWPVNQKVFLFKGSGYWQWDELARTDLSRYPKPIKELFTGVPDRPSAAMSWQDGQVYFFKGKEYWRLNQQLRVAKGYPRNTTHWMHC | ||||||
Glycosylation | 464 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 479 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Lipidation | 512 | GPI-anchor amidated aspartate | ||||
Sequence: D | ||||||
Propeptide | PRO_0000028830 | 513-527 | Removed in mature form | |||
Sequence: SASLSFSANVTLLGA | ||||||
Glycosylation | 521 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
Activated by autolytic cleavage after Lys-98.
Tyrosine phosphorylated by PKDCC/VLK.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in the liver. Expressed in the arterial tunica media of large blood vessels.
Developmental stage
Expressed in proliferating chondrocytes in the chondroepiphysis during musculoskeletal development.
Gene expression databases
Structure
Family & Domains
Features
Showing features for motif, repeat, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 84-91 | Cysteine switch | ||||
Sequence: PRCGLEDP | ||||||
Repeat | 286-333 | Hemopexin 1 | ||||
Sequence: PNPCSGEVDAMVLGPRGKTYAFKGDYVWTVTDSGPGPLFQISALWEGL | ||||||
Repeat | 334-372 | Hemopexin 2 | ||||
Sequence: PGNLDAAVYSPRTRRTHFFKGNKVWRYVDFKMSPGFPMK | ||||||
Repeat | 377-425 | Hemopexin 3 | ||||
Sequence: EPNLDAALYWPVNQKVFLFKGSGYWQWDELARTDLSRYPKPIKELFTGV | ||||||
Repeat | 426-471 | Hemopexin 4 | ||||
Sequence: PDRPSAAMSWQDGQVYFFKGKEYWRLNQQLRVAKGYPRNTTHWMHC | ||||||
Region | 473-500 | Disordered | ||||
Sequence: SQTPDTNSSTGDVTPSTTDTVLGTTPST |
Domain
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence similarities
Belongs to the peptidase M10A family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length527
- Mass (Da)59,122
- Last updated2000-10-01 v1
- Checksum8AD0AE41A1CD335E
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q3UW97 | Q3UW97_MOUSE | Mmp19 | 455 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF155221 EMBL· GenBank· DDBJ | AAF73292.1 EMBL· GenBank· DDBJ | mRNA | ||
AF162446 EMBL· GenBank· DDBJ | AAF80464.1 EMBL· GenBank· DDBJ | mRNA | ||
AF153199 EMBL· GenBank· DDBJ | AAG29880.1 EMBL· GenBank· DDBJ | mRNA | ||
AK086808 EMBL· GenBank· DDBJ | BAC39747.1 EMBL· GenBank· DDBJ | mRNA |