Q9JHG6 · RCAN1_MOUSE
- ProteinCalcipressin-1
- GeneRcan1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids251 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (PubMed:11231093).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | calcium-dependent protein serine/threonine phosphatase regulator activity | |
Molecular Function | nucleic acid binding | |
Biological Process | calcineurin-NFAT signaling cascade | |
Biological Process | calcium-mediated signaling | |
Biological Process | locomotion involved in locomotory behavior | |
Biological Process | negative regulation of calcineurin-NFAT signaling cascade | |
Biological Process | negative regulation of smooth muscle cell differentiation | |
Biological Process | response to estrogen | |
Biological Process | response to ischemia | |
Biological Process | response to oxidative stress | |
Biological Process | response to stress | |
Biological Process | short-term memory | |
Biological Process | skeletal muscle fiber development |
Names & Taxonomy
Protein names
- Recommended nameCalcipressin-1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9JHG6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000211415 | 1-251 | Calcipressin-1 | |||
Sequence: MEDGVAGPRLGEVAEAVEARAPRRVTLRPFAPFSAAAEGDGGGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDTTFQYFKSFKRVRINFSNPLSAADARLRLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQENEEEEEEMERMKRPKPKIIQTRRPEYTPIHLS | ||||||
Modified residue | 161 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 165 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 216 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in heart and skeletal muscle. Also expressed in all other tissues.
Gene expression databases
Interaction
Subunit
Interacts with RAF1 and PPP3R1 (By similarity).
Interacts with PPP3CA (PubMed:12809556).
Interacts with PPP3CA (PubMed:12809556).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9JHG6 | Dyrk1a Q61214 | 2 | EBI-644061, EBI-80344 | |
BINARY | Q9JHG6 | Fmr1 P35922 | 3 | EBI-644061, EBI-645094 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 216-251 | Disordered | ||||
Sequence: SDQENEEEEEEMERMKRPKPKIIQTRRPEYTPIHLS | ||||||
Compositional bias | 225-239 | Basic and acidic residues | ||||
Sequence: EEMERMKRPKPKIIQ |
Sequence similarities
Belongs to the RCAN family.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
Q9JHG6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameA
- Synonyms1, CALP1-L
- Length251
- Mass (Da)28,137
- Last updated2018-05-23 v2
- Checksum09F47C73D847FB2B
Q9JHG6-2
- NameB
- Synonyms4
- Differences from canonical
- 1-81: MEDGVAGPRLGEVAEAVEARAPRRVTLRPFAPFSAAAEGDGGGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLC → MHFRDFSYNFSSLIACVANDDVFSESET
Q9JHG6-3
- NameC
- Differences from canonical
- 1-133: Missing
Q9JHG6-4
- NameE
- SynonymsCALP1-S
- Differences from canonical
- 1-53: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A338P7E2 | A0A338P7E2_MOUSE | Rcan1 | 59 |
Sequence caution
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_059568 | 1-53 | in isoform E | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_001317 | 1-81 | in isoform B | |||
Sequence: MEDGVAGPRLGEVAEAVEARAPRRVTLRPFAPFSAAAEGDGGGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLC → MHFRDFSYNFSSLIACVANDDVFSESET | ||||||
Alternative sequence | VSP_001318 | 1-133 | in isoform C | |||
Sequence: Missing | ||||||
Sequence conflict | 2 | In isoform Q9JHG6-2; in Ref. 1; AAF63486 | ||||
Sequence: H → D | ||||||
Sequence conflict | 6 | In isoform Q9JHG6-2; in Ref. 4; AAF72701 | ||||
Sequence: F → Y | ||||||
Sequence conflict | 205 | in Ref. 1; AAF63485/AAF63486 | ||||
Sequence: T → P | ||||||
Compositional bias | 225-239 | Basic and acidic residues | ||||
Sequence: EEMERMKRPKPKIIQ |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF237789 EMBL· GenBank· DDBJ | AAF63485.1 EMBL· GenBank· DDBJ | mRNA | ||
AF237790 EMBL· GenBank· DDBJ | AAF63486.1 EMBL· GenBank· DDBJ | mRNA | ||
AF260717 EMBL· GenBank· DDBJ | AAF70343.1 EMBL· GenBank· DDBJ | mRNA | ||
AY325904 EMBL· GenBank· DDBJ | AAP96744.1 EMBL· GenBank· DDBJ | mRNA | ||
AF263239 EMBL· GenBank· DDBJ | AAF72701.1 EMBL· GenBank· DDBJ | mRNA | ||
AF263240 EMBL· GenBank· DDBJ | AAF72702.1 EMBL· GenBank· DDBJ | mRNA | ||
AK010696 EMBL· GenBank· DDBJ | BAB27128.1 EMBL· GenBank· DDBJ | mRNA | ||
AK146764 EMBL· GenBank· DDBJ | BAE27416.1 EMBL· GenBank· DDBJ | mRNA | ||
AC162305 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC174448 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC013551 EMBL· GenBank· DDBJ | AAH13551.1 EMBL· GenBank· DDBJ | mRNA | ||
AF282255 EMBL· GenBank· DDBJ | AAF91461.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |