Q9JHG6 · RCAN1_MOUSE

  • Protein
    Calcipressin-1
  • Gene
    Rcan1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (PubMed:11231093).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functioncalcium-dependent protein serine/threonine phosphatase regulator activity
Molecular Functionnucleic acid binding
Biological Processcalcineurin-NFAT signaling cascade
Biological Processcalcium-mediated signaling
Biological Processlocomotion involved in locomotory behavior
Biological Processnegative regulation of calcineurin-NFAT signaling cascade
Biological Processnegative regulation of smooth muscle cell differentiation
Biological Processresponse to estrogen
Biological Processresponse to ischemia
Biological Processresponse to oxidative stress
Biological Processresponse to stress
Biological Processshort-term memory
Biological Processskeletal muscle fiber development

Names & Taxonomy

Protein names

  • Recommended name
    Calcipressin-1
  • Alternative names
    • Down syndrome critical region protein 1 homolog
    • Myocyte-enriched calcineurin-interacting protein 1 (MCIP1)
    • Regulator of calcineurin 1

Gene names

    • Name
      Rcan1
    • Synonyms
      Dscr1

Organism names

  • Taxonomic identifier
  • Strains
    • NIH Swiss
    • C57BL/6J
    • BALB/cJ
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9JHG6
  • Secondary accessions
    • Q7TNY3
    • Q91WQ4
    • Q9JK50
    • Q9JK51
    • Q9JKK2
    • Q9JKK3

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002114151-251Calcipressin-1
Modified residue161Phosphoserine
Modified residue165Phosphoserine
Modified residue216Phosphoserine

Post-translational modification

Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in heart and skeletal muscle. Also expressed in all other tissues.

Gene expression databases

Interaction

Subunit

Interacts with RAF1 and PPP3R1 (By similarity).
Interacts with PPP3CA (PubMed:12809556).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9JHG6Dyrk1a Q612142EBI-644061, EBI-80344
BINARY Q9JHG6Fmr1 P359223EBI-644061, EBI-645094

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region216-251Disordered
Compositional bias225-239Basic and acidic residues

Sequence similarities

Belongs to the RCAN family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing. Additional isoforms seem to exist.

Q9JHG6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    A
  • Synonyms
    1, CALP1-L
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    251
  • Mass (Da)
    28,137
  • Last updated
    2018-05-23 v2
  • Checksum
    09F47C73D847FB2B
MEDGVAGPRLGEVAEAVEARAPRRVTLRPFAPFSAAAEGDGGGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDTTFQYFKSFKRVRINFSNPLSAADARLRLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQENEEEEEEMERMKRPKPKIIQTRRPEYTPIHLS

Q9JHG6-2

  • Name
    B
  • Synonyms
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-81: MEDGVAGPRLGEVAEAVEARAPRRVTLRPFAPFSAAAEGDGGGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLC → MHFRDFSYNFSSLIACVANDDVFSESET

Q9JHG6-3

  • Name
    C
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9JHG6-4

  • Name
    E
  • Synonyms
    CALP1-S
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A338P7E2A0A338P7E2_MOUSERcan159

Sequence caution

The sequence AAF91461.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0595681-53in isoform E
Alternative sequenceVSP_0013171-81in isoform B
Alternative sequenceVSP_0013181-133in isoform C
Sequence conflict2In isoform Q9JHG6-2; in Ref. 1; AAF63486
Sequence conflict6In isoform Q9JHG6-2; in Ref. 4; AAF72701
Sequence conflict205in Ref. 1; AAF63485/AAF63486
Compositional bias225-239Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF237789
EMBL· GenBank· DDBJ
AAF63485.1
EMBL· GenBank· DDBJ
mRNA
AF237790
EMBL· GenBank· DDBJ
AAF63486.1
EMBL· GenBank· DDBJ
mRNA
AF260717
EMBL· GenBank· DDBJ
AAF70343.1
EMBL· GenBank· DDBJ
mRNA
AY325904
EMBL· GenBank· DDBJ
AAP96744.1
EMBL· GenBank· DDBJ
mRNA
AF263239
EMBL· GenBank· DDBJ
AAF72701.1
EMBL· GenBank· DDBJ
mRNA
AF263240
EMBL· GenBank· DDBJ
AAF72702.1
EMBL· GenBank· DDBJ
mRNA
AK010696
EMBL· GenBank· DDBJ
BAB27128.1
EMBL· GenBank· DDBJ
mRNA
AK146764
EMBL· GenBank· DDBJ
BAE27416.1
EMBL· GenBank· DDBJ
mRNA
AC162305
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC174448
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC013551
EMBL· GenBank· DDBJ
AAH13551.1
EMBL· GenBank· DDBJ
mRNA
AF282255
EMBL· GenBank· DDBJ
AAF91461.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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