Q9J3N8 · VME1_IBVDE

Function

function

Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell Golgi membrane
Cellular Componentmembrane
Cellular Componentviral envelope
Cellular Componentvirion membrane
Molecular Functionstructural constituent of virion

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Membrane protein
  • Short names
    M protein
  • Alternative names
    • E1 glycoprotein
    • Matrix glycoprotein
    • Membrane glycoprotein

Gene names

    • Name
      M

Organism names

  • Taxonomic identifier
  • Strains
    • Isolate AR/6386/97
    • Isolate GA/5381/99
    • Isolate GA/5658/99
    • Isolate IL/2831/98
    • Isolate KS/5425/99
    • Isolate MN/6370/97
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Gammacoronavirus > Igacovirus > Avian coronavirus

Accessions

  • Primary accession
    Q9J3N8
  • Secondary accessions
    • Q9J3N9
    • Q9J3P0
    • Q9J3P1
    • Q9J3P2
    • Q9J3P3
    • Q9J4B3

Subcellular Location

Virion membrane
; Multi-pass membrane protein
Host Golgi apparatus membrane
; Multi-pass membrane protein
Note: Largely embedded in the lipid bilayer.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-20Virion surface
Transmembrane21-41Helical
Topological domain42-51Intravirion
Transmembrane52-72Helical
Topological domain73-77Virion surface
Transmembrane78-98Helical
Topological domain99-225Intravirion

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant2in strain: Isolate AR/6386/97
Natural variant2-4in strain: Isolate MN/6370/97
Natural variant11-12in strain: Isolate MN/6370/97
Natural variant15-16in strain: Isolate MN/6370/97
Natural variant16in strain: Isolate IL/2831/98
Natural variant17in strain: Isolate AR/6386/97
Natural variant34in strain: Isolate GA/5381/99
Natural variant35in strain: Isolate IL/2831/98 and Isolate MN/6370/97
Natural variant44in strain: Isolate AR/6386/97
Natural variant44-49in strain: Isolate IL/2831/98
Natural variant45in strain: Isolate MN/6370/97
Natural variant46in strain: Isolate GA/5381/99
Natural variant49-50in strain: Isolate MN/6370/97
Natural variant53in strain: Isolate AR/6386/97, Isolate GA/5381/99, Isolate GA/5658/99 and Isolate KS/5425/99
Natural variant62in strain: Isolate KS/5425/99
Natural variant76in strain: Isolate GA/5381/99
Natural variant101in strain: Isolate IL/2831/98
Natural variant108in strain: Isolate IL/2831/98
Natural variant112in strain: Isolate MN/6370/97
Natural variant132in strain: Isolate MN/6370/97
Natural variant140in strain: Isolate AR/6386/97, Isolate IL/2831/98, Isolate GA/5381/99, Isolate GA/5658/99, Isolate KS/5425/99 and Isolate MN/6370/97
Natural variant150in strain: Isolate GA/5381/99
Natural variant150in strain: Isolate AR/6386/97, Isolate GA/5658/99, Isolate IL/2831/98, Isolate KS/5425/99 and Isolate MN/6370/97
Natural variant180in strain: Isolate IL/2831/98

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 24 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001060541-225Membrane protein

Keywords

Interaction

Subunit

Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.

Structure

3D structure databases

Family & Domains

Sequence similarities

Belongs to the gammacoronaviruses M protein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    225
  • Mass (Da)
    25,557
  • Last updated
    2003-07-11 v2
  • Checksum
    082246BAAD20D74C
MSNETNCTLDFEQSVELFKEYNLFITAFLLFLTIILQYGYATRSKFIYILKMIVLWCFWPLNIAVGVISCIYPPNTGGLVAAIILTVFACLSFVGYWIQSIRLFKRCRSWWSFNPESNAVGSILLTNGQQCNFAIESVPTVLSPIIKNGFLYCEGQWLAKCEPDHLPKDIFVCTPDRRNIYRMVQKYTGDQSGNKKRFATFVYAKQSVDTGELESVATGGSSLYT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF202999
EMBL· GenBank· DDBJ
AAF69113.1
EMBL· GenBank· DDBJ
Genomic RNA
AF206266
EMBL· GenBank· DDBJ
AAF67556.1
EMBL· GenBank· DDBJ
Genomic RNA
AF206267
EMBL· GenBank· DDBJ
AAF67557.1
EMBL· GenBank· DDBJ
Genomic RNA
AF206268
EMBL· GenBank· DDBJ
AAF67558.1
EMBL· GenBank· DDBJ
Genomic RNA
AF206269
EMBL· GenBank· DDBJ
AAF67559.1
EMBL· GenBank· DDBJ
Genomic RNA
AF206270
EMBL· GenBank· DDBJ
AAF67560.1
EMBL· GenBank· DDBJ
Genomic RNA
AF206271
EMBL· GenBank· DDBJ
AAF67561.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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