Q9J3N8 · VME1_IBVDE
- ProteinMembrane protein
- GeneM
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids225 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell Golgi membrane | |
Cellular Component | membrane | |
Cellular Component | viral envelope | |
Cellular Component | virion membrane | |
Molecular Function | structural constituent of virion |
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameMembrane protein
- Short namesM protein
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Gammacoronavirus > Igacovirus > Avian coronavirus
- Virus hosts
Accessions
- Primary accessionQ9J3N8
- Secondary accessions
Subcellular Location
UniProt Annotation
GO Annotation
Virion membrane ; Multi-pass membrane protein
Host Golgi apparatus membrane ; Multi-pass membrane protein
Note: Largely embedded in the lipid bilayer.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-20 | Virion surface | ||||
Sequence: MSNETNCTLDFEQSVELFKE | ||||||
Transmembrane | 21-41 | Helical | ||||
Sequence: YNLFITAFLLFLTIILQYGYA | ||||||
Topological domain | 42-51 | Intravirion | ||||
Sequence: TRSKFIYILK | ||||||
Transmembrane | 52-72 | Helical | ||||
Sequence: MIVLWCFWPLNIAVGVISCIY | ||||||
Topological domain | 73-77 | Virion surface | ||||
Sequence: PPNTG | ||||||
Transmembrane | 78-98 | Helical | ||||
Sequence: GLVAAIILTVFACLSFVGYWI | ||||||
Topological domain | 99-225 | Intravirion | ||||
Sequence: QSIRLFKRCRSWWSFNPESNAVGSILLTNGQQCNFAIESVPTVLSPIIKNGFLYCEGQWLAKCEPDHLPKDIFVCTPDRRNIYRMVQKYTGDQSGNKKRFATFVYAKQSVDTGELESVATGGSSLYT |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 2 | in strain: Isolate AR/6386/97 | ||||
Sequence: S → A | ||||||
Natural variant | 2-4 | in strain: Isolate MN/6370/97 | ||||
Sequence: SNE → DNV | ||||||
Natural variant | 11-12 | in strain: Isolate MN/6370/97 | ||||
Sequence: FE → LQ | ||||||
Natural variant | 15-16 | in strain: Isolate MN/6370/97 | ||||
Sequence: VE → IL | ||||||
Natural variant | 16 | in strain: Isolate IL/2831/98 | ||||
Sequence: E → K | ||||||
Natural variant | 17 | in strain: Isolate AR/6386/97 | ||||
Sequence: L → F | ||||||
Natural variant | 34 | in strain: Isolate GA/5381/99 | ||||
Sequence: I → M | ||||||
Natural variant | 35 | in strain: Isolate IL/2831/98 and Isolate MN/6370/97 | ||||
Sequence: I → L | ||||||
Natural variant | 44 | in strain: Isolate AR/6386/97 | ||||
Sequence: S → I | ||||||
Natural variant | 44-49 | in strain: Isolate IL/2831/98 | ||||
Sequence: SKFIYI → NRLIYA | ||||||
Natural variant | 45 | in strain: Isolate MN/6370/97 | ||||
Sequence: K → R | ||||||
Natural variant | 46 | in strain: Isolate GA/5381/99 | ||||
Sequence: F → I | ||||||
Natural variant | 49-50 | in strain: Isolate MN/6370/97 | ||||
Sequence: IL → VM | ||||||
Natural variant | 53 | in strain: Isolate AR/6386/97, Isolate GA/5381/99, Isolate GA/5658/99 and Isolate KS/5425/99 | ||||
Sequence: I → V | ||||||
Natural variant | 62 | in strain: Isolate KS/5425/99 | ||||
Sequence: N → I | ||||||
Natural variant | 76 | in strain: Isolate GA/5381/99 | ||||
Sequence: T → I | ||||||
Natural variant | 101 | in strain: Isolate IL/2831/98 | ||||
Sequence: I → C | ||||||
Natural variant | 108 | in strain: Isolate IL/2831/98 | ||||
Sequence: R → K | ||||||
Natural variant | 112 | in strain: Isolate MN/6370/97 | ||||
Sequence: S → A | ||||||
Natural variant | 132 | in strain: Isolate MN/6370/97 | ||||
Sequence: N → S | ||||||
Natural variant | 140 | in strain: Isolate AR/6386/97, Isolate IL/2831/98, Isolate GA/5381/99, Isolate GA/5658/99, Isolate KS/5425/99 and Isolate MN/6370/97 | ||||
Sequence: T → M | ||||||
Natural variant | 150 | in strain: Isolate GA/5381/99 | ||||
Sequence: F → A | ||||||
Natural variant | 150 | in strain: Isolate AR/6386/97, Isolate GA/5658/99, Isolate IL/2831/98, Isolate KS/5425/99 and Isolate MN/6370/97 | ||||
Sequence: F → V | ||||||
Natural variant | 180 | in strain: Isolate IL/2831/98 | ||||
Sequence: I → T |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 24 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000106054 | 1-225 | Membrane protein | |||
Sequence: MSNETNCTLDFEQSVELFKEYNLFITAFLLFLTIILQYGYATRSKFIYILKMIVLWCFWPLNIAVGVISCIYPPNTGGLVAAIILTVFACLSFVGYWIQSIRLFKRCRSWWSFNPESNAVGSILLTNGQQCNFAIESVPTVLSPIIKNGFLYCEGQWLAKCEPDHLPKDIFVCTPDRRNIYRMVQKYTGDQSGNKKRFATFVYAKQSVDTGELESVATGGSSLYT |
Keywords
- PTM
Interaction
Subunit
Homomultimer. Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Forms a complex with HE and S proteins. Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.
Sequence
- Sequence statusComplete
- Length225
- Mass (Da)25,557
- Last updated2003-07-11 v2
- Checksum082246BAAD20D74C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF202999 EMBL· GenBank· DDBJ | AAF69113.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AF206266 EMBL· GenBank· DDBJ | AAF67556.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AF206267 EMBL· GenBank· DDBJ | AAF67557.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AF206268 EMBL· GenBank· DDBJ | AAF67558.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AF206269 EMBL· GenBank· DDBJ | AAF67559.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AF206270 EMBL· GenBank· DDBJ | AAF67560.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
AF206271 EMBL· GenBank· DDBJ | AAF67561.1 EMBL· GenBank· DDBJ | Genomic RNA |