Q9J3G6 · Q9J3G6_9HEPC

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell endoplasmic reticulum membrane
Cellular Componenthost cell lipid droplet
Cellular Componenthost cell mitochondrial membrane
Cellular Componenthost cell nucleus
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componenthost cell plasma membrane
Cellular Componentlipid droplet
Cellular Componentplasma membrane
Cellular Componentribonucleoprotein complex
Cellular Componentviral envelope
Cellular Componentviral nucleocapsid
Cellular Componentvirion membrane
Molecular FunctionATP binding
Molecular Functionchannel activity
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type endopeptidase activity
Molecular Functionstructural molecule activity
Molecular Functionzinc ion binding
Biological Processapoptotic process
Biological Processclathrin-dependent endocytosis of virus by host cell
Biological Processfusion of virus membrane with host endosome membrane
Biological Processinduction by virus of host autophagy
Biological Processmonoatomic ion transmembrane transport
Biological Processproteolysis
Biological Processsymbiont-mediated perturbation of host cell cycle G1/S transition checkpoint
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
Biological Processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
Biological Processsymbiont-mediated suppression of host TRAF-mediated signal transduction
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processtransformation of host cell by virus
Biological Processviral RNA genome replication
Biological Processvirion attachment to host cell
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Strain
    • MD26
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Hepacivirus > Hepacivirus hominis

Accessions

  • Primary accession
    Q9J3G6

Proteomes

Subcellular Location

Cell membrane
Cytoplasm
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Peripheral membrane protein
Endoplasmic reticulum membrane
; Single-pass membrane protein
Endoplasmic reticulum membrane
; Single-pass type I membrane protein
Host cell membrane
Host endoplasmic reticulum membrane
; Multi-pass membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host endoplasmic reticulum membrane
; Single-pass membrane protein
Host endoplasmic reticulum membrane
; Single-pass type I membrane protein
Host lipid droplet
Host mitochondrion membrane
; Single-pass type I membrane protein
Host nucleus
Lipid droplet
Membrane
; Multi-pass membrane protein
Membrane
; Peripheral membrane protein
Membrane
; Single-pass membrane protein
Membrane
; Single-pass type I membrane protein
Mitochondrion membrane
; Single-pass type I membrane protein
Virion membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane718-740Helical
Transmembrane752-778Helical
Transmembrane784-803Helical
Transmembrane815-835Helical
Transmembrane891-913Helical
Transmembrane1660-1688Helical
Transmembrane1825-1845Helical
Transmembrane1851-1870Helical
Transmembrane1882-1902Helical
Transmembrane2990-3007Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-77Disordered
Compositional bias47-68Basic and acidic residues
Domain903-1026Peptidase C18
Domain1027-1208Peptidase S29
Domain1217-1369Helicase ATP-binding
Domain1361-1538Helicase C-terminal
Region2187-2220Disordered
Compositional bias2195-2217Polar residues
Compositional bias2347-2369Polar residues
Region2347-2407Disordered
Domain2633-2751RdRp catalytic

Sequence similarities

Belongs to the hepacivirus polyprotein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,010
  • Mass (Da)
    327,169
  • Last updated
    2000-10-01 v1
  • Checksum
    74FAB6B80F24837B
MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARQPEGRTWAQPGYPWPLYGNEGMGWAGWLLSPRGSRPSWGPTDPRRRSRNLGKVIDTLTCGFADLMGYIPLVGAPLGGAARALAHGVRVLEDSVNYATGNLPGCSFSIFLLALLSCLTTPASAYEVRNVSGIYHVTNDCSNSSIVYEAADIIMHAPGCTPCVREGKSSRCWVALTPTLAARNISVPTTTIRRHVDLLVGAAAFCSAMYVGDLCGSVFLVGQLFTLSPRRHQTVQDCNCSIYPGHVSGHRMAWDMMMNWSPTAALVVSQLLRIPQAIMDMVVGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVDGDTRVTGGASAHNTRTFTSFFTSGPSQKIQLVNTNGSWHINRTALNCNDSLQTGFLAALFYTHRFNASGCPERMASCRPIDNFDQGWGPITYAEPNSPDQRPYCWHYALRPCGTTPASGVCGPVYCFTPSPVVVGTTDRFGAPTYNWGENETDVLLLNNTRLPQGNWFGCTWMNSTGFTKTCGGPPCNIGGAGNNTLICPTDCFRKHPEATYTKCGSGPWLTPRCLVDYPYRLWHYPCTVNFTIFKVRMYVGGVEHRLSAACNWTRGERCGLEDRDRSELSPLLLSTTEWQILPCSFTTLPALSTGLIHLHRNIVDVQYLYGIGSAVVSFAIKWEYVVLLFLLLADARVCACLWMMLLVAQAEAALENLVVLNAASVAGAHGILSFLVFFCAAWYIKGRLVPGAAYALYGVWPLLLLLLALPPRAYALDREMAASCGGGVFVGLALLTLSPYYKVFLARLIWWLQYFITRAEAHLQVWIPPLNVRGGRDAIILLVCAVHPELIFDITKLLLAIFGPLMVLQASITRVPYFVRAQGLIRACMLVRKVAGGHYVQMALVKLAALTGTYVYDHLAPLQHWAHAGLRDLAVAVEPVVFSDMETKIITWGADTAACGDIILGLPVSARRGREILLGPADSFEGQGWRLLAPITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVFHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSMTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPLGHVVGIFRAAVCTRGVAKAVDFVPVESMETTMRSPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAYGTDPNIRTGIRTITTGAPITYSTYGKFLADGGCSGGAYDIIICDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEVALSNTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLSALGLNAVAYYRGLDVSVIPTSGDVVVVATDALMTGYTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRIGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPSETTVRLRAYLNTPGLPVCQDHLEFWESVFTGLTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVTLTHPITKFIMTCMAADLEVVTSTWVLVGGVLAALAAYCLTTGSVVIVGRIILSGKPAVIPDREVLYREFDEMEECASHLPYIEQGMQLAEQFKQKALGLLQTATKQAEAAAPAVESKWRALEAFWAKHMWNFISGIQYLAGLSTLPGNPAIASLMAFTASITSPLTTQNTLLFNILGGWVAAQLAPPSAASAFVGAGIAGAAVGSIGLGKVLVDILAGYGAGVAGALVAFKIMSGEMPSTEDLVNLLPAILSPGALVVGVVCAAILRRHVGPGEGAVQWMNRLIAFASRGNHVSPTHYVPESDAAARVTQILSSLTITQLLKRLHQWINEDCSTPCSGSWLRDVWDWICTVLTDFKTWLQSKLMPRLPGVPFFSCQRGYKGVWRGDGIMQTTCPCGAQITGHVKNGSMRIVGPKTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFQVGLNQYVVGSQLPCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLRAEEDEREVSVAAEILRKTRKFPAAMPVWARPDYNPPLLESWKDPDYVPPVVHGCPLPPTKAPPIPPPRRKRTVVLTESTVSSALAELGTKTFGSSESSAVDSGTATAPPDQASDDGDKGSDAESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCCSMSYTWTGALITPCAAEESKLPIIPLSYSLLRHHNMVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKYGYGAKDVRNLSSKAVNHIRSVWEDLLEDTETPINTTIMAKSEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTESDIRTEESIYQCCDLAPEARLAIRSLTERLYVGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICESAGTEEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKAQDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRAKLLSQGGRAATCGKYLFNWAVRTKLKLTPIPAASRLDLSGWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias47-68Basic and acidic residues
Compositional bias2195-2217Polar residues
Compositional bias2347-2369Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF207767
EMBL· GenBank· DDBJ
AAF65957.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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