Q9J3G4 · Q9J3G4_9HEPC
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3010 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Cofactor
Protein has several cofactor binding sites:
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Hepacivirus > Hepacivirus hominis
Accessions
- Primary accessionQ9J3G4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Single-pass membrane protein
Endoplasmic reticulum membrane ; Single-pass type I membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Single-pass membrane protein
Host endoplasmic reticulum membrane ; Single-pass type I membrane protein
Host mitochondrion membrane ; Single-pass type I membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Membrane ; Single-pass membrane protein
Membrane ; Single-pass type I membrane protein
Mitochondrion membrane ; Single-pass type I membrane protein
Virion membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 718-740 | Helical | ||||
Sequence: YVLLFFLLLADARVCACLWMMLL | ||||||
Transmembrane | 752-778 | Helical | ||||
Sequence: VILNAASVAGAHGILSFLVFFCAAWYI | ||||||
Transmembrane | 784-803 | Helical | ||||
Sequence: PGAAYVLYGVWPLLLLLLAL | ||||||
Transmembrane | 815-835 | Helical | ||||
Sequence: AASCGGAVFLGLAFLTLSPYY | ||||||
Transmembrane | 891-913 | Helical | ||||
Sequence: LLLAILGPLMVLQAGLIRVPYFV | ||||||
Transmembrane | 1660-1688 | Helical | ||||
Sequence: WVLVGGVLAALAAYCLTTGSVVIVGRIIL | ||||||
Transmembrane | 1825-1845 | Helical | ||||
Sequence: AASAFVGAGIAGAAVGSIGLG | ||||||
Transmembrane | 1851-1870 | Helical | ||||
Sequence: ILAGYGAGVAGALVAFKIMS | ||||||
Transmembrane | 1882-1902 | Helical | ||||
Sequence: LLPAILSPGALVVGVVCAAIL | ||||||
Transmembrane | 2990-3007 | Helical | ||||
Sequence: WFMLCLLLLSVGVGIYLL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-77 | Disordered | ||||
Sequence: MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPKLGVRATRKTSERSQPRGRRQPIPKARQPEGRSWA | ||||||
Compositional bias | 47-68 | Basic and acidic residues | ||||
Sequence: RATRKTSERSQPRGRRQPIPKA | ||||||
Domain | 903-1026 | Peptidase C18 | ||||
Sequence: QAGLIRVPYFVRAQGLIRACMLVRKVAGGHYIQMAFVKLAALTGTYVYDHLTPLRDWAHSGLRDLAVAVEPVVFSAMETKIITWGADTAACGDIILGLPVSARRGREIFLGPADSLEGQGWRLL | ||||||
Domain | 1027-1208 | Peptidase S29 | ||||
Sequence: APITAYAQQTRGLFGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCINGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPSGARSLTPCTCGSSDLYLVTRHADVIPVRRRSDGRGSLLSPRPISYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFIPVESMETTMRSP | ||||||
Domain | 1217-1369 | Helicase ATP-binding | ||||
Sequence: PAVPQSFQVAHLHAPTGSGKSTRVPAAYAAQGYKVLVLNPSVAATLGFGTYMSKAYGTDPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDIIICDECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEVALSN | ||||||
Domain | 1361-1538 | Helicase C-terminal | ||||
Sequence: NIEEVALSNTGEIPFYGKAIPIEAIKGGRHLIFCHSKKKCDELAAQLTALGINAVAYYRGLDVSIIPTSGDVVVVATDALMTGYTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTVPQDSVSRSQRRGRTGRGRGGIYRYVIPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVR | ||||||
Region | 2187-2223 | Disordered | ||||
Sequence: RRRLARGSPPSLASSSASQLSAPSLKATCTTHHGSPD | ||||||
Compositional bias | 2195-2223 | Polar residues | ||||
Sequence: PPSLASSSASQLSAPSLKATCTTHHGSPD | ||||||
Region | 2351-2407 | Disordered | ||||
Sequence: TFGGPGSETADSGTATAPPDQAFNDGDNGSDVESYSSMPPLEGEPGDPDLSDGSWST | ||||||
Compositional bias | 2357-2385 | Polar residues | ||||
Sequence: SETADSGTATAPPDQAFNDGDNGSDVESY | ||||||
Domain | 2633-2751 | RdRp catalytic | ||||
Sequence: PMGFSYDTRCFDSTVTESDIRTEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQSCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLRDCTMLVNGDDLVVICESAGTQED |
Sequence similarities
Belongs to the hepacivirus polyprotein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,010
- Mass (Da)327,322
- Last updated2000-10-01 v1
- Checksum0595728AC62464F3
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 47-68 | Basic and acidic residues | ||||
Sequence: RATRKTSERSQPRGRRQPIPKA | ||||||
Compositional bias | 2195-2223 | Polar residues | ||||
Sequence: PPSLASSSASQLSAPSLKATCTTHHGSPD | ||||||
Compositional bias | 2357-2385 | Polar residues | ||||
Sequence: SETADSGTATAPPDQAFNDGDNGSDVESY |