Q9IZG6 · Q9IZG6_HPV58

Function

function

Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.

Miscellaneous

Belongs to the high risk human alphapapillomavirus family. The cancer-causing human papillomavirus E6 protein has a unique carboxy terminal PDZ domain containing substrate.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular FunctionPDZ domain binding
Biological ProcessDNA-templated transcription
Biological Processregulation of DNA-templated transcription
Biological Processsymbiont-mediated perturbation of host apoptosis
Biological Processsymbiont-mediated perturbation of host ubiquitin-like protein modification
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein E6

Gene names

    • Name
      E6

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • E6HK2
    • E6/E7-HK-14
    • E6/E7-HK-3
    • E6/E7-HK-5
    • HPV58sc101
  • Taxonomic lineage
    Viruses > Monodnaviria > Shotokuvirae > Cossaviricota > Papovaviricetes > Zurhausenvirales > Papillomaviridae > Firstpapillomavirinae > Alphapapillomavirus > Alphapapillomavirus 9

Accessions

  • Primary accession
    Q9IZG6

Proteomes

Subcellular Location

Keywords

Expression

Keywords

Interaction

Subunit

Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP and thus forms a complex with human TP53. Interacts with human NFX1 and MAGI3. Interacts with human IRF3; this interaction inhibits the establishment of antiviral state. Interacts with human TYK2; this interaction inhibits JAK-STAT activation by interferon alpha. Interacts with host DLG1; this interaction leads to the proteasomal degradation of DLG1.

Family & Domains

Features

Showing features for zinc finger, motif.

Type
IDPosition(s)Description
Zinc finger30-66
Zinc finger103-139
Motif147-149PDZ-binding domain

Sequence similarities

Belongs to the papillomaviridae E6 protein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    149
  • Mass (Da)
    17,780
  • Last updated
    2000-10-01 v1
  • MD5 Checksum
    2A51AA278EAC5430B7584DCC3039AAC2
MFQDAEEKPRTLHDLCQALETSVHEIELKCVECKKTLQRSEVYDFVFADLRIVYRDGNPFAVCKVCLRLLSKISEYRHYNYSLYGDTLEQTLNKCLNEILIRCIICQRPLCPQEKKRHVDLNKRFHNISGRWTGRCAVCWRPRRRQTQV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF234530
EMBL· GenBank· DDBJ
AAF60306.1
EMBL· GenBank· DDBJ
Genomic DNA
AF478152
EMBL· GenBank· DDBJ
AAL85397.1
EMBL· GenBank· DDBJ
Genomic DNA
AF478154
EMBL· GenBank· DDBJ
AAL85399.1
EMBL· GenBank· DDBJ
Genomic DNA
AF478163
EMBL· GenBank· DDBJ
AAL85408.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ385262
EMBL· GenBank· DDBJ
ACJ13457.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ385263
EMBL· GenBank· DDBJ
ACJ13465.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ385265
EMBL· GenBank· DDBJ
ACJ13481.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ385266
EMBL· GenBank· DDBJ
ACJ13489.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ385268
EMBL· GenBank· DDBJ
ACJ13505.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ407193
EMBL· GenBank· DDBJ
ACK37631.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ407194
EMBL· GenBank· DDBJ
ACK37636.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ407195
EMBL· GenBank· DDBJ
ACK37646.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ407199
EMBL· GenBank· DDBJ
ACK37664.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ407201
EMBL· GenBank· DDBJ
ACK37678.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ407203
EMBL· GenBank· DDBJ
ACK37686.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ407209
EMBL· GenBank· DDBJ
ACK37736.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ407212
EMBL· GenBank· DDBJ
ACK37756.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ407214
EMBL· GenBank· DDBJ
ACK37770.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ407215
EMBL· GenBank· DDBJ
ACK37780.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ407217
EMBL· GenBank· DDBJ
ACK37800.1
EMBL· GenBank· DDBJ
Genomic DNA
JX401164
EMBL· GenBank· DDBJ
AFO70366.1
EMBL· GenBank· DDBJ
Genomic DNA
JX401171
EMBL· GenBank· DDBJ
AFO70373.1
EMBL· GenBank· DDBJ
Genomic DNA
JX401172
EMBL· GenBank· DDBJ
AFO70374.1
EMBL· GenBank· DDBJ
Genomic DNA
JX401173
EMBL· GenBank· DDBJ
AFO70375.1
EMBL· GenBank· DDBJ
Genomic DNA
JX401175
EMBL· GenBank· DDBJ
AFO70377.1
EMBL· GenBank· DDBJ
Genomic DNA
JX401176
EMBL· GenBank· DDBJ
AFO70378.1
EMBL· GenBank· DDBJ
Genomic DNA
JX401182
EMBL· GenBank· DDBJ
AFO70384.1
EMBL· GenBank· DDBJ
Genomic DNA
JX401184
EMBL· GenBank· DDBJ
AFO70386.1
EMBL· GenBank· DDBJ
Genomic DNA
KC190276
EMBL· GenBank· DDBJ
AFY09735.1
EMBL· GenBank· DDBJ
Genomic DNA
KC860270
EMBL· GenBank· DDBJ
AGQ21857.1
EMBL· GenBank· DDBJ
Genomic DNA
KX354761
EMBL· GenBank· DDBJ
ANM72850.1
EMBL· GenBank· DDBJ
Genomic DNA
KX354762
EMBL· GenBank· DDBJ
ANM72852.1
EMBL· GenBank· DDBJ
Genomic DNA
KX354766
EMBL· GenBank· DDBJ
ANM72860.1
EMBL· GenBank· DDBJ
Genomic DNA
KX354767
EMBL· GenBank· DDBJ
ANM72862.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225918
EMBL· GenBank· DDBJ
ASQ41702.1
EMBL· GenBank· DDBJ
Genomic DNA
KY225919
EMBL· GenBank· DDBJ
ASQ41710.1
EMBL· GenBank· DDBJ
Genomic DNA
MF741323
EMBL· GenBank· DDBJ
AWA45981.1
EMBL· GenBank· DDBJ
Genomic DNA
MF741327
EMBL· GenBank· DDBJ
AWA45989.1
EMBL· GenBank· DDBJ
Genomic DNA
MF741331
EMBL· GenBank· DDBJ
AWA45997.1
EMBL· GenBank· DDBJ
Genomic DNA
MH348919
EMBL· GenBank· DDBJ
AZC11041.1
EMBL· GenBank· DDBJ
Genomic DNA
MH348922
EMBL· GenBank· DDBJ
AZC11047.1
EMBL· GenBank· DDBJ
Genomic DNA
MH348927
EMBL· GenBank· DDBJ
AZC11057.1
EMBL· GenBank· DDBJ
Genomic DNA
MH348929
EMBL· GenBank· DDBJ
AZC11061.1
EMBL· GenBank· DDBJ
Genomic DNA
MH348932
EMBL· GenBank· DDBJ
AZC11067.1
EMBL· GenBank· DDBJ
Genomic DNA
MH348933
EMBL· GenBank· DDBJ
AZC11069.1
EMBL· GenBank· DDBJ
Genomic DNA
MK343263
EMBL· GenBank· DDBJ
QHI05744.1
EMBL· GenBank· DDBJ
Genomic DNA
MK343264
EMBL· GenBank· DDBJ
QHI05745.1
EMBL· GenBank· DDBJ
Genomic DNA
MK343265
EMBL· GenBank· DDBJ
QHI05746.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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