Both the genome instability and cell death of MRE11-null and MRE11-mutated H129N cells are significantly reversed by overexpression of Tdp2 an enzyme that eliminates covalent Top2 conjugates; thus the essential role of Mre11 nuclease activity is likely to remove the DNA lesions.
although Mre11 is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs Mre11 is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.
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