Q9IA95 · SFRP3_CHICK

  • Protein
    Secreted frizzled-related protein 3
  • Gene
    FRZB
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular space
Molecular FunctionWnt-protein binding
Biological Processcanonical Wnt signaling pathway
Biological Processcochlea morphogenesis
Biological Processconvergent extension involved in organogenesis
Biological Processepithelial cell development
Biological Processhepatocyte differentiation
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of cartilage development
Biological Processnegative regulation of cell development
Biological Processnegative regulation of cell growth
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of hepatocyte differentiation
Biological Processnegative regulation of Wnt signaling pathway
Biological Processneural crest cell differentiation
Biological Processnon-canonical Wnt signaling pathway
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of fat cell differentiation
Biological Processsomite development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Secreted frizzled-related protein 3
  • Short names
    sFRP-3
  • Alternative names
    • Frizzled-related protein 1
    • FrzB-1

Gene names

    • Name
      FRZB
    • Synonyms
      SFRP3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    Q9IA95
  • Secondary accessions
    • Q4U3E3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000003254922-315
Disulfide bond27↔88
Disulfide bond35↔81
Glycosylation41N-linked (GlcNAc...) asparagine
Disulfide bond72↔111
Disulfide bond100↔139
Disulfide bond104↔128

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

At stage 7 of embryonic development, expressed in the neural plate with lower expression in the midline. At stage 9, expression restricted to the dorsal neural tube and cranial neural crest. At stage 12, expressed in the lateral plate mesoderm. In the developing trunk, expressed, from stages 9-12, in the ventral migrating neural crest with some expression at stage 12 in the dorsal streams From stage 15, expressed in the endocardial cells of the outflow tract of the developing heart. From stage 18, expression found in the epibranchial placodes, in endocardial and mesenchymal cells of the developing atrioventricular canal and of the outflow tract cushions. Expression in these regions of the developing heart continue until stage 26. During limb development, low expression found, by stage 18, in the developing limb buds, By stage 20, highly expressed in the ventral mesenchyme of both fore- and hind-limb buds. By stage 24, expression localized to the central core of the developing limb bud, which contains the chondrogenic precursors. Also expressed in the surrounding nonchondrogenic mesenchyme. Later expression confined to the perichondrium and to the epiphyses of the early developing skeletal elements.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain22-142FZ
Domain170-290NTR
Region284-315Disordered

Domain

The FZ domain is involved in binding with Wnt ligands.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    315
  • Mass (Da)
    35,004
  • Last updated
    2000-10-01 v1
  • Checksum
    6EBC58DB5335505D
MWRGLPALALAALLLLGRAPAGRAAACEPVRIPLCKPLPWNMTKMPNHLHHSTQANAVLAMEQFEGLLGTNCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARAGCEPVLIRYRHAWPESLACDELPLYDRGVCISPEAIVTAEGADFPMDSNNGNCRGTGIERCKCKPIKATQKTYLRNNYNYVIRAKVKEVKTKCHDVTAVVEVKEILKSSLVNIPKDTVNLYTNSGCLCPPLSANEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDQKLRHLGKGKGEPGQSDSALKTGKPGNARQTRS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8V0YA55A0A8V0YA55_CHICKFRZB299

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF218057
EMBL· GenBank· DDBJ
AAF27643.1
EMBL· GenBank· DDBJ
mRNA
DQ017062
EMBL· GenBank· DDBJ
AAY42147.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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