Q9IA95 · SFRP3_CHICK
- ProteinSecreted frizzled-related protein 3
- GeneFRZB
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids315 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSecreted frizzled-related protein 3
- Short namessFRP-3
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionQ9IA95
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MWRGLPALALAALLLLGRAPA | ||||||
Chain | PRO_0000032549 | 22-315 | Secreted frizzled-related protein 3 | |||
Sequence: GRAAACEPVRIPLCKPLPWNMTKMPNHLHHSTQANAVLAMEQFEGLLGTNCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARAGCEPVLIRYRHAWPESLACDELPLYDRGVCISPEAIVTAEGADFPMDSNNGNCRGTGIERCKCKPIKATQKTYLRNNYNYVIRAKVKEVKTKCHDVTAVVEVKEILKSSLVNIPKDTVNLYTNSGCLCPPLSANEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDQKLRHLGKGKGEPGQSDSALKTGKPGNARQTRS | ||||||
Disulfide bond | 27↔88 | |||||
Sequence: CEPVRIPLCKPLPWNMTKMPNHLHHSTQANAVLAMEQFEGLLGTNCSPDLLFFLCAMYAPIC | ||||||
Disulfide bond | 35↔81 | |||||
Sequence: CKPLPWNMTKMPNHLHHSTQANAVLAMEQFEGLLGTNCSPDLLFFLC | ||||||
Glycosylation | 41 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 72↔111 | |||||
Sequence: CSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARAGC | ||||||
Disulfide bond | 100↔139 | |||||
Sequence: CKSVCERARAGCEPVLIRYRHAWPESLACDELPLYDRGVC | ||||||
Disulfide bond | 104↔128 | |||||
Sequence: CERARAGCEPVLIRYRHAWPESLAC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
At stage 7 of embryonic development, expressed in the neural plate with lower expression in the midline. At stage 9, expression restricted to the dorsal neural tube and cranial neural crest. At stage 12, expressed in the lateral plate mesoderm. In the developing trunk, expressed, from stages 9-12, in the ventral migrating neural crest with some expression at stage 12 in the dorsal streams From stage 15, expressed in the endocardial cells of the outflow tract of the developing heart. From stage 18, expression found in the epibranchial placodes, in endocardial and mesenchymal cells of the developing atrioventricular canal and of the outflow tract cushions. Expression in these regions of the developing heart continue until stage 26. During limb development, low expression found, by stage 18, in the developing limb buds, By stage 20, highly expressed in the ventral mesenchyme of both fore- and hind-limb buds. By stage 24, expression localized to the central core of the developing limb bud, which contains the chondrogenic precursors. Also expressed in the surrounding nonchondrogenic mesenchyme. Later expression confined to the perichondrium and to the epiphyses of the early developing skeletal elements.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 22-142 | FZ | ||||
Sequence: GRAAACEPVRIPLCKPLPWNMTKMPNHLHHSTQANAVLAMEQFEGLLGTNCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARAGCEPVLIRYRHAWPESLACDELPLYDRGVCISP | ||||||
Domain | 170-290 | NTR | ||||
Sequence: CKCKPIKATQKTYLRNNYNYVIRAKVKEVKTKCHDVTAVVEVKEILKSSLVNIPKDTVNLYTNSGCLCPPLSANEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDQKLRHLGK | ||||||
Region | 284-315 | Disordered | ||||
Sequence: KLRHLGKGKGEPGQSDSALKTGKPGNARQTRS |
Domain
The FZ domain is involved in binding with Wnt ligands.
Sequence similarities
Belongs to the secreted frizzled-related protein (sFRP) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length315
- Mass (Da)35,004
- Last updated2000-10-01 v1
- Checksum6EBC58DB5335505D
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8V0YA55 | A0A8V0YA55_CHICK | FRZB | 299 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF218057 EMBL· GenBank· DDBJ | AAF27643.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ017062 EMBL· GenBank· DDBJ | AAY42147.1 EMBL· GenBank· DDBJ | mRNA |