Q9I9K9 · GATM_CHICK
- ProteinGlycine amidinotransferase, mitochondrial
- GeneGATM
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids422 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity).
Catalytic activity
- glycine + L-arginine = guanidinoacetate + L-ornithine
Pathway
Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 253 | |||||
Sequence: D | ||||||
Active site | 302 | |||||
Sequence: H | ||||||
Active site | 406 | Amidino-cysteine intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrion | |
Molecular Function | amidinotransferase activity | |
Molecular Function | glycine amidinotransferase activity | |
Biological Process | creatine biosynthetic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycine amidinotransferase, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionQ9I9K9
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for transit peptide, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-37 | Mitochondrion | ||||
Sequence: MLRVRCLRGGSRGAEAAHFIGSRLGRAFTGWVQRSLQ | ||||||
Chain | PRO_0000399095 | 38-422 | Glycine amidinotransferase, mitochondrial | |||
Sequence: STQAAAASQNRCAAEDKAQSPAPKECPVCSYNEWDPLEEVIVGRAENACVPPFSVEVKANTYEKYWGFYQKFGGESFPKDHVKKAIAEIEEMCNILKKEGVIVKRPDPIDWSVKYRTPDFESTGMYAAMPRDILLVVGNEIIEAPMAWRARFFEYRAYRRIIKDYFNNGAKWTTAPKPTMADELYDQDYPIRSVEDRHKLAAQGKFVTTEFEPCFDAADFIRAGRDIFVQRSQVTNYMGIEWMRRHLAPDYRVHVISFKDPNPMHIDTTFNIIGPGLVLSNPDRPCHQIELFKKAGWTVIHPPVPLIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANETSIQKMFENLGISTIKVNIRHANSLGGGFHCWTCDIRRRGTLQSYFD | ||||||
Modified residue | 416 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
Expression
Induction
Transiently induced by estrogen, with levels peaking an hour after hormone injection.
Interaction
Structure
Family & Domains
Sequence similarities
Belongs to the amidinotransferase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length422
- Mass (Da)48,311
- Last updated2010-10-05 v2
- ChecksumD4896DCF97C7FD27
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 18 | in Ref. 2; AAF61951 | ||||
Sequence: H → N | ||||||
Sequence conflict | 20 | in Ref. 2; AAF61951 | ||||
Sequence: I → M | ||||||
Sequence conflict | 50 | in Ref. 2; AAF61951 | ||||
Sequence: A → P | ||||||
Sequence conflict | 149 | in Ref. 2; AAF61951 | ||||
Sequence: S → P |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BU129729 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
AF237950 EMBL· GenBank· DDBJ | AAF61951.2 EMBL· GenBank· DDBJ | mRNA | Different initiation |