Q9I9K9 · GATM_CHICK

  • Protein
    Glycine amidinotransferase, mitochondrial
  • Gene
    GATM
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity).

Catalytic activity

Pathway

Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2.

Features

Showing features for active site.

142250100150200250300350400
TypeIDPosition(s)Description
Active site253
Active site302
Active site406Amidino-cysteine intermediate

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrion
Molecular Functionamidinotransferase activity
Molecular Functionglycine amidinotransferase activity
Biological Processcreatine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycine amidinotransferase, mitochondrial
  • EC number
  • Alternative names
    • L-arginine:glycine amidinotransferase
    • Transamidinase

Gene names

    • Name
      GATM
    • Synonyms
      AT

Organism names

  • Taxonomic identifier
  • Strain
    • White Leghorn Hisex
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    Q9I9K9

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue.

TypeIDPosition(s)Description
Transit peptide1-37Mitochondrion
ChainPRO_000039909538-422Glycine amidinotransferase, mitochondrial
Modified residue416Phosphothreonine

Keywords

Proteomic databases

Expression

Induction

Transiently induced by estrogen, with levels peaking an hour after hormone injection.

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the amidinotransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    422
  • Mass (Da)
    48,311
  • Last updated
    2010-10-05 v2
  • Checksum
    D4896DCF97C7FD27
MLRVRCLRGGSRGAEAAHFIGSRLGRAFTGWVQRSLQSTQAAAASQNRCAAEDKAQSPAPKECPVCSYNEWDPLEEVIVGRAENACVPPFSVEVKANTYEKYWGFYQKFGGESFPKDHVKKAIAEIEEMCNILKKEGVIVKRPDPIDWSVKYRTPDFESTGMYAAMPRDILLVVGNEIIEAPMAWRARFFEYRAYRRIIKDYFNNGAKWTTAPKPTMADELYDQDYPIRSVEDRHKLAAQGKFVTTEFEPCFDAADFIRAGRDIFVQRSQVTNYMGIEWMRRHLAPDYRVHVISFKDPNPMHIDTTFNIIGPGLVLSNPDRPCHQIELFKKAGWTVIHPPVPLIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANETSIQKMFENLGISTIKVNIRHANSLGGGFHCWTCDIRRRGTLQSYFD

Sequence caution

The sequence AAF61951.2 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict18in Ref. 2; AAF61951
Sequence conflict20in Ref. 2; AAF61951
Sequence conflict50in Ref. 2; AAF61951
Sequence conflict149in Ref. 2; AAF61951

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BU129729
EMBL· GenBank· DDBJ
-mRNA No translation available.
AF237950
EMBL· GenBank· DDBJ
AAF61951.2
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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