Q9I929 · FUCL3_ANGJA
- ProteinFucolectin-3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids180 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.
Miscellaneous
Binds 1 calcium ion per monomer.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 58 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 61 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 63 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 72 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 75 | alpha-L-fucose (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 101 | alpha-L-fucose (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 108 | alpha-L-fucose (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 168 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 169 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | calcium ion binding | |
Molecular Function | carbohydrate binding | |
Molecular Function | fucose binding | |
Biological Process | regulation of cellular defense response | |
Biological Process | regulation of complement activation, lectin pathway | |
Biological Process | regulation of innate immune response |
Keywords
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameFucolectin-3
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Anguilliformes > Anguillidae > Anguilla
Accessions
- Primary accessionQ9I929
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MEVKMIILLFQILAISTLKSDS | ||||||
Chain | PRO_0000223934 | 23-180 | Fucolectin-3 | |||
Sequence: ADIPEGYIQENVALRGRATQSAQLKGEFAGFAHASNAIDGNRDSNYHHGSCSHTEGDNSWWRVDLKQVYTITSVTITNRGDCCGERISGARILIGKHLENNGINNPECSTINIMAAGETKTFHCPQPMIGRYVTVYLPKAESLQLCEVEVNVLFPAPC | ||||||
Disulfide bond | 73↔168 | |||||
Sequence: CSHTEGDNSWWRVDLKQVYTITSVTITNRGDCCGERISGARILIGKHLENNGINNPECSTINIMAAGETKTFHCPQPMIGRYVTVYLPKAESLQLC | ||||||
Disulfide bond | 104↔105 | |||||
Sequence: CC | ||||||
Disulfide bond | 130↔146 | |||||
Sequence: CSTINIMAAGETKTFHC |
Keywords
- PTM
Expression
Tissue specificity
Parenchymal hepatocytes.
Interaction
Subunit
Homotrimer.
Structure
Family & Domains
Features
Showing features for region, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 31-179 | F5/8 type C-like | ||||
Sequence: QENVALRGRATQSAQLKGEFAGFAHASNAIDGNRDSNYHHGSCSHTEGDNSWWRVDLKQVYTITSVTITNRGDCCGERISGARILIGKHLENNGINNPECSTINIMAAGETKTFHCPQPMIGRYVTVYLPKAESLQLCEVEVNVLFPAP | ||||||
Motif | 101-103 | Cell attachment site | ||||
Sequence: RGD |
Sequence similarities
Belongs to the fucolectin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length180
- Mass (Da)19,770
- Last updated2000-10-01 v1
- ChecksumA68941AFB5A09190