Q9I8L5 · FA10A_DANRE
- ProteinFatty acid-binding protein 10-A, liver basic
- Genefabp10a
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids126 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Binds hydrophobic ligands, such as cholate, in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
Binds one cholate per subunit
Binds one cholate per subunit
Miscellaneous
A member of the basic liver-type FABPs, which are only found, thus far, in non-mammalian vertebrates.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | bile acid binding | |
Molecular Function | fatty acid binding | |
Biological Process | fatty acid transport |
Keywords
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameFatty acid-binding protein 10-A, liver basic
- Short namesZf-FABP10; Zf-Lb-FABP
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ9I8L5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 56 | No effect on cholate binding stoichiometry. | ||||
Sequence: G → R | ||||||
Mutagenesis | 92 | Changes cholate binding stoichiometry so that 2 cholate molecules are bound per subunit. | ||||
Sequence: C → T |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000312344 | 1-126 | Fatty acid-binding protein 10-A, liver basic | |||
Sequence: MAFSGTWQVYAQENYEEFLRAISLPEEVIKLAKDVKPVTEIQQNGSDFTITSKTPGKTVTNSFTIGKEAEITTMDGKKLKCIVKLDGGKLVCRTDRFSHIQEIKAGEMVETLTVGGTTMIRKSKKI |
Proteomic databases
Expression
Tissue specificity
Expressed in the developing embryonic liver from 48 hpf. Also expressed in the liver of 5-day-old larvae. In adults, primarily expressed in the liver, with weak expression in the testis and intestine.
Developmental stage
Expressed in the embryo at 6 dpf to 8 dpf.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Domain
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Sequence similarities
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length126
- Mass (Da)14,004
- Last updated2000-10-01 v1
- ChecksumF77419F1F2489814
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF254642 EMBL· GenBank· DDBJ | AAF67743.1 EMBL· GenBank· DDBJ | mRNA | ||
BC076219 EMBL· GenBank· DDBJ | AAH76219.1 EMBL· GenBank· DDBJ | mRNA | ||
BC081518 EMBL· GenBank· DDBJ | AAH81518.1 EMBL· GenBank· DDBJ | mRNA | ||
AF512998 EMBL· GenBank· DDBJ | AAM47005.1 EMBL· GenBank· DDBJ | Genomic DNA |