Q9I8L5 · FA10A_DANRE

Function

function

Binds hydrophobic ligands, such as cholate, in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
Binds one cholate per subunit

Miscellaneous

A member of the basic liver-type FABPs, which are only found, thus far, in non-mammalian vertebrates.

Caution

PubMed:12633865 reports expression in the ventral endoderm at 36 hpf, whereas PubMed:16857010 does not detect expression this early. The different timings may reflect strain-specific differences.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site57cholate (UniProtKB | ChEBI)
Binding site77cholate (UniProtKB | ChEBI)
Binding site99cholate (UniProtKB | ChEBI)
Binding site101cholate (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionbile acid binding
Molecular Functionfatty acid binding
Biological Processfatty acid transport

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Fatty acid-binding protein 10-A, liver basic
  • Short names
    Zf-FABP10; Zf-Lb-FABP
  • Alternative names
    • Fatty acid-binding protein, liver
    • Liver bile acid-binding protein (L-BABP; z-L-BABP)
    • Liver-type fatty acid-binding protein (L-FABP; Liver-type FABP)

Gene names

    • Name
      fabp10a
    • Synonyms
      fabp10
    • ORF names
      zgc:103719, zgc:92741

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q9I8L5
  • Secondary accessions
    • Q8JHE8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis56No effect on cholate binding stoichiometry.
Mutagenesis92Changes cholate binding stoichiometry so that 2 cholate molecules are bound per subunit.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003123441-126Fatty acid-binding protein 10-A, liver basic

Proteomic databases

Expression

Tissue specificity

Expressed in the developing embryonic liver from 48 hpf. Also expressed in the liver of 5-day-old larvae. In adults, primarily expressed in the liver, with weak expression in the testis and intestine.

Developmental stage

Expressed in the embryo at 6 dpf to 8 dpf.

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Domain

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    126
  • Mass (Da)
    14,004
  • Last updated
    2000-10-01 v1
  • Checksum
    F77419F1F2489814
MAFSGTWQVYAQENYEEFLRAISLPEEVIKLAKDVKPVTEIQQNGSDFTITSKTPGKTVTNSFTIGKEAEITTMDGKKLKCIVKLDGGKLVCRTDRFSHIQEIKAGEMVETLTVGGTTMIRKSKKI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF254642
EMBL· GenBank· DDBJ
AAF67743.1
EMBL· GenBank· DDBJ
mRNA
BC076219
EMBL· GenBank· DDBJ
AAH76219.1
EMBL· GenBank· DDBJ
mRNA
BC081518
EMBL· GenBank· DDBJ
AAH81518.1
EMBL· GenBank· DDBJ
mRNA
AF512998
EMBL· GenBank· DDBJ
AAM47005.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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