Q9I6G4 · CARP_PSEAE

Function

function

Plays a role in intracellular Ca2+ homeostasis (PubMed:26755627).
Involved in modulating Ca2+-induced swarming motility and pyocyanine production (PubMed:26755627).
Plays a role in regulating virulence in a Ca2+-dependent manner (PubMed:33674436).
Involved in cell protection against oxidative stress in the presence of elevated Ca2+ (PubMed:33674436).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Biological Processcalcium ion homeostasis
Biological Processcell motility
Biological Processcellular response to hydrogen peroxide
Biological Processpyocyanine biosynthetic process
Biological Processresponse to calcium ion
Biological Processresponse to iron(II) ion

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Calcium-regulated beta-propeller protein CarP
  • Alternative names
    • Calcium-regulated protein CarP
    • Protein CarP

Gene names

    • Name
      carP
    • Ordered locus names
      PA0327

Organism names

Accessions

  • Primary accession
    Q9I6G4

Proteomes

Organism-specific databases

Subcellular Location

Cell inner membrane
; Peripheral membrane protein

Keywords

Phenotypes & Variants

Disruption phenotype

Impairs growth at high Ca2+ level, causing extended lag phase and decrease in growth rate (PubMed:26755627).
Raises the basal intracellular concentration of Ca2+, and impairs recovery to the resting intracellular Ca2+ (PubMed:26755627).
Significantly alters the morphology of swarming colonies at elevated Ca2+ (PubMed:26755627).
Reduces pyocyanine production by 72% (PubMed:26755627).
Increases sensitivity to tobramycin at high Ca2+ (PubMed:26755627).
Reduces survival of the greater wax moth Galleria mellonella infection model, when in the presence of 10mM CaCl2 (PubMed:33674436).

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-42
ChainPRO_000045911143-321Calcium-regulated beta-propeller protein CarP

Proteomic databases

Expression

Induction

Up-regulated by Ca2+, with the highest induction during the transition to the stationary phase of growth (PubMed:33674436).
Up-regulated by an unknown molecule secreted by P.aeruginosa during stationary phase, probably an autoinducer; induction is dependent upon one or more of the quorum-sensing synthases, LasL, RhlL and PqsA (PubMed:33674436).
Up-regulated by Fe2+; acts synergistically with Ca2+ (PubMed:33674436).
Up-regulated by UV as a part of the oxidative stress response (PubMed:33674436).

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the YjiK family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    321
  • Mass (Da)
    36,157
  • Last updated
    2001-03-01 v1
  • Checksum
    BCA1E5AFF48F7555
MTIHAQTPEPFSMSRAFTPRRLLLAVLLVALSALVLLGQSFRVFDRAWFAVQEWRHADAWKERSIWLPDYRVRIEAQPIEGLNDDVSALTFDPDRRTLFTVTNQPAQIIELSLQGKVLRTIPLTGFGDAEAIEYISRGVYVITDERQQRLVKVRLEDDTRFIDAADAQQLSLGIGLNGNKGFEGLAYDAEGKRLFVAKERDPVRIYEIHGFPHTQADKPFAVHVVDDPGRDKRLFVRDLSSLQFDEGTGHLLALSDESRLVVELDTDGEPVSTLSLLRGMHGLKRSVPQAEGVAMDDRGVLYLVSEPNLFYVFSKDEPAQP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE004091
EMBL· GenBank· DDBJ
AAG03716.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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