Q9I6G4 · CARP_PSEAE
- ProteinCalcium-regulated beta-propeller protein CarP
- GenecarP
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids321 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Plays a role in intracellular Ca2+ homeostasis (PubMed:26755627).
Involved in modulating Ca2+-induced swarming motility and pyocyanine production (PubMed:26755627).
Plays a role in regulating virulence in a Ca2+-dependent manner (PubMed:33674436).
Involved in cell protection against oxidative stress in the presence of elevated Ca2+ (PubMed:33674436).
Involved in modulating Ca2+-induced swarming motility and pyocyanine production (PubMed:26755627).
Plays a role in regulating virulence in a Ca2+-dependent manner (PubMed:33674436).
Involved in cell protection against oxidative stress in the presence of elevated Ca2+ (PubMed:33674436).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Biological Process | calcium ion homeostasis | |
Biological Process | cell motility | |
Biological Process | cellular response to hydrogen peroxide | |
Biological Process | pyocyanine biosynthetic process | |
Biological Process | response to calcium ion | |
Biological Process | response to iron(II) ion |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCalcium-regulated beta-propeller protein CarP
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionQ9I6G4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Impairs growth at high Ca2+ level, causing extended lag phase and decrease in growth rate (PubMed:26755627).
Raises the basal intracellular concentration of Ca2+, and impairs recovery to the resting intracellular Ca2+ (PubMed:26755627).
Significantly alters the morphology of swarming colonies at elevated Ca2+ (PubMed:26755627).
Reduces pyocyanine production by 72% (PubMed:26755627).
Increases sensitivity to tobramycin at high Ca2+ (PubMed:26755627).
Reduces survival of the greater wax moth Galleria mellonella infection model, when in the presence of 10mM CaCl2 (PubMed:33674436).
Raises the basal intracellular concentration of Ca2+, and impairs recovery to the resting intracellular Ca2+ (PubMed:26755627).
Significantly alters the morphology of swarming colonies at elevated Ca2+ (PubMed:26755627).
Reduces pyocyanine production by 72% (PubMed:26755627).
Increases sensitivity to tobramycin at high Ca2+ (PubMed:26755627).
Reduces survival of the greater wax moth Galleria mellonella infection model, when in the presence of 10mM CaCl2 (PubMed:33674436).
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-42 | |||||
Sequence: MTIHAQTPEPFSMSRAFTPRRLLLAVLLVALSALVLLGQSFR | ||||||
Chain | PRO_0000459111 | 43-321 | Calcium-regulated beta-propeller protein CarP | |||
Sequence: VFDRAWFAVQEWRHADAWKERSIWLPDYRVRIEAQPIEGLNDDVSALTFDPDRRTLFTVTNQPAQIIELSLQGKVLRTIPLTGFGDAEAIEYISRGVYVITDERQQRLVKVRLEDDTRFIDAADAQQLSLGIGLNGNKGFEGLAYDAEGKRLFVAKERDPVRIYEIHGFPHTQADKPFAVHVVDDPGRDKRLFVRDLSSLQFDEGTGHLLALSDESRLVVELDTDGEPVSTLSLLRGMHGLKRSVPQAEGVAMDDRGVLYLVSEPNLFYVFSKDEPAQP |
Proteomic databases
Expression
Induction
Up-regulated by Ca2+, with the highest induction during the transition to the stationary phase of growth (PubMed:33674436).
Up-regulated by an unknown molecule secreted by P.aeruginosa during stationary phase, probably an autoinducer; induction is dependent upon one or more of the quorum-sensing synthases, LasL, RhlL and PqsA (PubMed:33674436).
Up-regulated by Fe2+; acts synergistically with Ca2+ (PubMed:33674436).
Up-regulated by UV as a part of the oxidative stress response (PubMed:33674436).
Up-regulated by an unknown molecule secreted by P.aeruginosa during stationary phase, probably an autoinducer; induction is dependent upon one or more of the quorum-sensing synthases, LasL, RhlL and PqsA (PubMed:33674436).
Up-regulated by Fe2+; acts synergistically with Ca2+ (PubMed:33674436).
Up-regulated by UV as a part of the oxidative stress response (PubMed:33674436).
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length321
- Mass (Da)36,157
- Last updated2001-03-01 v1
- ChecksumBCA1E5AFF48F7555
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE004091 EMBL· GenBank· DDBJ | AAG03716.1 EMBL· GenBank· DDBJ | Genomic DNA |