Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J.[...], Olson M.V.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1CategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 406:959-964 (2000)Cited in99+99+
A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism.Cao H., Krishnan G., Goumnerov B., Tsongalis J., Tompkins R., Rahme L.G.View abstractCited forFUNCTION, SUBCELLULAR LOCATIONCategoriesFunction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 98:14613-14618 (2001)Cited in1
MvfR, a key Pseudomonas aeruginosa pathogenicity LTTR-class regulatory protein, has dual ligands.Xiao G., Deziel E., He J., Lepine F., Lesic B., Castonguay M.H., Milot S., Tampakaki A.P., Stachel S.E., Rahme L.G.View abstractCited forFUNCTION, ACTIVITY REGULATIONCategoryFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Microbiol. 62:1689-1699 (2006)Cited in1
Evidence for direct control of virulence and defense gene circuits by the Pseudomonas aeruginosa quorum sensing regulator, MvfR.Maura D., Hazan R., Kitao T., Ballok A.E., Rahme L.G.View abstractCited forFUNCTIONCategoryFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCSci. Rep. 6:34083-34083 (2016)Cited in1
Molecular Insights into Function and Competitive Inhibition of Pseudomonas aeruginosa Multiple Virulence Factor Regulator.Kitao T., Lepine F., Babloudi S., Walte F., Steinbacher S., Maskos K., Blaesse M., Negri M., Pucci M.[...], Rahme L.G.View abstractCited forX-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 94-295, SUBUNITCategoriesInteraction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMBio 9:0-0 (2018)Cited in1
Design, Synthesis, and Evaluation of New 1<i>H</i>- Benzo[<i>d</i>]imidazole Based PqsR Inhibitors as Adjuvant Therapy for <i>Pseudomonas aeruginosa</i> Infections.Soukarieh F., Mashabi A., Richardson W., Oton E.V., Romero M., Dubern J.F., Robertson S.N., Lucanto S., Markham-Lee Z.[...], Camara M.View abstractCategoryStructureSourcePDB: 8Q5K, PDB: 8Q5LPubMedEurope PMCJ Med Chem 67:1008-1023 (2024)Mapped to1
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle.Hamed M.M., Abdelsamie A.S., Rox K., Schutz C., Kany A.M., Rohrig T., Schmelz S., Blankenfeldt W., Arce-Rodriguez A.[...], Empting M.View abstractCategoryStructureSourcePDB: 7P4UPubMedEurope PMCAdv Sci (Weinh) 10:e2204443-e2204443 (2023)Mapped to1
Divergent synthesis and biological evaluation of 2- (trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR.Schutz C., Hodzic A., Hamed M., Abdelsamie A.S., Kany A.M., Bauer M., Rohrig T., Schmelz S., Scrima A.[...], Empting M.View abstractCategoryStructureSourcePDB: 7NBWPubMedEurope PMCEur J Med Chem 226:113797-113797 (2021)Mapped to1
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms.Schutz C., Ho D.K., Hamed M.M., Abdelsamie A.S., Rohrig T., Herr C., Kany A.M., Rox K., Schmelz S.[...], Empting M.View abstractCategoryStructureSourcePDB: 6YIZPubMedEurope PMCAdv Sci (Weinh) 8:e2004369-e2004369 (2021)Mapped to1
Flexible Fragment Growing Boosts Potency of Quorum-Sensing Inhibitors against Pseudomonas aeruginosa Virulence.Zender M., Witzgall F., Kiefer A., Kirsch B., Maurer C.K., Kany A.M., Xu N., Schmelz S., Borger C.[...], Empting M.View abstractCategoryStructureSourcePDB: 6Q7U, PDB: 6Q7V, PDB: 6Q7WPubMedEurope PMCChemMedChem 15:188-194 (2020)Mapped to1