Q9I4X0 · MVFR_PSEAE

Function

function

Transcription regulator that plays a critical role in virulence by positively regulating the expression of multiple quorum sensing (QS)-regulated virulence factors, genes involved in protein secretion, translation, response to oxidative stress and the phnAB operon (PubMed:11724939, PubMed:17083468, PubMed:27678057).
At the stationary phase, negatively autoregulates its function through cleavage and translocation to the extracellular space (PubMed:11724939).

Activity regulation

Both 3,4-dihydroxy-2-heptylquinoline (PQS) and its precursor 4-hydroxy-2-heptylquinoline (HHQ) function as ligands and promote MvfR DNA-binding activity leading to transcriptional activation.

Features

Showing features for dna binding.

133250100150200250300
TypeIDPosition(s)Description
DNA binding21-40H-T-H motif

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componentplasma membrane
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity
Biological Processregulation of DNA-templated transcription
Biological Processregulation of transmembrane transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multiple virulence factor regulator MvfR
  • Alternative names
    • Transcriptional regulator MvfR

Gene names

    • Name
      mvfR
    • Ordered locus names
      PA1003

Organism names

Accessions

  • Primary accession
    Q9I4X0

Proteomes

Organism-specific databases

Subcellular Location

Cell inner membrane
Secreted
Note: At stationary phase, gets cleaved and subsequently released in the extracellular space where its transcriptional activity is inhibited.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004485311-332Multiple virulence factor regulator MvfR

Proteomic databases

Interaction

Subunit

Forms homooligomers.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-61HTH lysR-type

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    332
  • Mass (Da)
    37,214
  • Last updated
    2001-03-01 v1
  • Checksum
    117430C3C1232D97
MPIHNLNHVNMFLQVIASGSISSAARILRKSHTAVSSAVSNLEIDLCVELVRRDGYKVEPTEQALRLIPYMRSLLNYQQLIGDIAFNLNKGPRNLRVLLDTAIPPSFCDTVSSVLLDDFNMVSLIRTSPADSLATIKQDNAEIDIAITIDEELKISRFNQCVLGYTKAFVVAHPQHPLCNASLHSIASLANYRQISLGSRSGQHSNLLRPVSDKVLFVENFDDMLRLVEAGVGWGIAPHYFVEERLRNGTLAVLSELYEPGGIDTKVYCYYNTALESERSFLRFLESARQRLRELGRQRFDDAPAWQPSIVETAQRRSGPKALAYRQRAAPE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE004091
EMBL· GenBank· DDBJ
AAG04392.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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