Q9HZX3 · TGPA_PSEAE

Function

function

Displays transglutaminase activity (TGase) in vitro. Plays a critical role in the viability of P.aeruginosa. Might contribute to an essential function linked to the cell wall.

Miscellaneous

Unlike Guinea pig TGase, TGase activity is not affected by EDTA addition, suggesting that TGase activity is Ca2+-independent, similar to members of the bacterial transglutaminase family.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site404Nucleophile
Active site448
Active site464

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionprotein-glutamine gamma-glutamyltransferase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein-glutamine gamma-glutamyltransferase
  • EC number
  • Alternative names
    • Transglutaminase protein A (TGase A)

Gene names

    • Name
      tgpA
    • Ordered locus names
      PA2873

Organism names

Accessions

  • Primary accession
    Q9HZX3

Proteomes

Organism-specific databases

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-6Cytoplasmic
Transmembrane7-27Helical
Topological domain28-50Periplasmic
Transmembrane51-71Helical
Topological domain72-74Cytoplasmic
Transmembrane75-95Helical
Topological domain96-103Periplasmic
Transmembrane104-124Helical
Transmembrane125-145Helical
Topological domain146-158Cytoplasmic
Transmembrane159-179Helical
Topological domain180-548Periplasmic
Transmembrane549-569Helical
Topological domain570-668Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Disruption experiments show that tgpA is essential.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004224191-668Protein-glutamine gamma-glutamyltransferase

Proteomic databases

Expression

Induction

Is expressed in both exponential and stationary phases of growth. Appears to be part of an operon together with PA2874 and PA2875.

Interaction

Protein-protein interaction databases

Family & Domains

Domain

The transglutaminase activity is contained within the periplasmic domain (180-544).

Sequence similarities

Belongs to the transglutaminase-like superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    668
  • Mass (Da)
    74,807
  • Last updated
    2001-03-01 v1
  • Checksum
    646CD6D34F6E96D4
MNAIPRVALVWLLVAQVLVILPHLAYMPLWIAAMWLGCAAWRVQVFRMRAGYPRAWVKLALALLAGAGVWLSRGSLVGLDAGAVLLIAAFILKLVEMKTRRDALVLVFLGFFAVVVGYLFDDGFLAALYSLLPVTALLAALIGLQQSAFASRPWPTLRLAGGLLLQALPLMLLLFLFFPRLGPLWSLPMPGNKGVTGLSESMAPGDIAELGRSAELAFRVRFEGALPPREQLYWRALTMERFDGRRWAQAPQWSGEDALHWQKRGPELRYDVIMQPSSQPWLFALDVAQTDQTDTRLMSDFHLQRRQPVEQRLFYRVSSWPQALRESSIDPRTRWRNLQLPMHGNPRARALADELRQAHAQPQALVAALLQRFNHEPFAYTLKPPATGADGVDDFLFDTRSGFCAHYAGAMAFVLRAAGIPARVVAGYQGGELNPAGNYLLVHQFDAHAWVEYWQPEQGWLSVDPTYQVAPERIEQGLEQALAGDSEYLADAPLSPLRYRGLPWLNDMRLAWDSLNYGWQRWVLAYQGEQQGAFLQRWFGGLDPTRLGLLLGAAAILSVGLLALFLLKPWQGRGDLRSRQLRRFERLLEMHGLRRSPGEGLRSYGERAARVLPAQAPAIAAFVGAFEAQRYGHGGADDPGLRLRALRRALPWRLVRTPTRDGRGEEQA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE004091
EMBL· GenBank· DDBJ
AAG06261.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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