Q9HWH2 · PHZM_PSEAE

Function

function

Involved in the biosynthesis of pyocyanine, a blue-pigmented phenazine derivative, which plays a role in virulence. Converts phenazine-1-carboxylate (PCA) to 5-methylphenazine-1-carboxylate (5-methyl-PCA).

Catalytic activity

Activity regulation

In vitro, requires PhzS for activity.

Pathway

Secondary metabolite biosynthesis; pyocyanine biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site198S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site241S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function5-methyl-phenazine-1-carboxylate N-methyltransferase activity
Molecular Functionidentical protein binding
Molecular FunctionO-methyltransferase activity
Molecular Functionprotein homodimerization activity
Molecular FunctionS-adenosyl-L-methionine binding
Molecular FunctionS-adenosylmethionine-dependent methyltransferase activity
Biological Processmethylation
Biological Processpyocyanine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phenazine-1-carboxylate N-methyltransferase
  • EC number

Gene names

    • Name
      phzM
    • Ordered locus names
      PA4209

Organism names

Accessions

  • Primary accession
    Q9HWH2

Proteomes

Organism-specific databases

Phenotypes & Variants

Miscellaneous

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004417071-334Phenazine-1-carboxylate N-methyltransferase

Proteomic databases

Interaction

Subunit

Homodimer in solution (PubMed:16946471, PubMed:17253782).
Probably interacts transiently with PhzS (PubMed:17253782).

Protein-protein interaction databases

Family & Domains

Domain

Contains an N-terminal dimerization domain. The C-terminal region contains the S-adenosyl-L-methionine binding site.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    334
  • Mass (Da)
    36,357
  • Last updated
    2001-03-01 v1
  • Checksum
    27D9717ECA12A1B5
MNNSNLAAARNLIQVVTGEWKSRCVYVATRLGLADLIESGIDSDETLAAAVGSDAERIHRLMRLLVAFEIFQGDTRDGYANTPTSHLLRDVEGSFRDMVLFYGEEFHAAWTPACEALLSGTPGFELAFGEDFYSYLKRCPDAGRRFLLAMKASNLAFHEIPRLLDFRGRSFVDVGGGSGELTKAILQAEPSARGVMLDREGSLGVARDNLSSLLAGERVSLVGGDMLQEVPSNGDIYLLSRIIGDLDEAASLRLLGNCREAMAGDGRVVVIERTISASEPSPMSVLWDVHLFMACAGRHRTTEEVVDLLGRGGFAVERIVDLPMETRMIVAARA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE004091
EMBL· GenBank· DDBJ
AAG07596.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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