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Q9HR35 · DNLI_HALSA

Function

function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

Catalytic activity

  • ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.
    EC:6.5.1.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

156150100150200250300350400450500550
Type
IDPosition(s)Description
Binding site253ATP (UniProtKB | ChEBI)
Active site255N6-AMP-lysine intermediate
Binding site260ATP (UniProtKB | ChEBI)
Binding site275ATP (UniProtKB | ChEBI)
Binding site304ATP (UniProtKB | ChEBI)
Binding site344ATP (UniProtKB | ChEBI)
Binding site421ATP (UniProtKB | ChEBI)
Binding site427ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA ligase (ATP) activity
Molecular Functionmetal ion binding
Biological Processcell division
Biological ProcessDNA biosynthetic process
Biological ProcessDNA ligation
Biological ProcessDNA recombination
Biological ProcessDNA repair
Biological Processlagging strand elongation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA ligase
  • EC number
  • Alternative names
    • Polydeoxyribonucleotide synthase [ATP]

Gene names

    • Name
      lig
    • Ordered locus names
      VNG_0881G

Organism names

Accessions

  • Primary accession
    Q9HR35

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000596021-561DNA ligase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    561
  • Mass (Da)
    59,620
  • Last updated
    2001-03-01 v1
  • MD5 Checksum
    177AD0C329ACC5DB5C3C9A3BC715F9F2
MKFGSFATFAADIEATDADLDVVALVAELFDAADSDLDVVARFVQGRVFPAHSETKLDIGPQLCYTALSRAAGRNVDADDIEARLAETGDIGAVAGSLDLGGQTGLAAFGGGDDHADGLTVSGVADELAALAAAAGDGSQSEKVTLLFGLFNQCTSREARYLARLVLGEMRIGVGEGAVRDAIAEAFDVPTAAVQRALQVSNDYGLVAETARDSGTDALDAMGLEVGRPVQAMLAQAGTVTDALDEWHEAAVETKFDGARVQVHYDGDDVVLYSRNMENVTGALPELVEFVENNVTAPVIIDGEAVAADEDGDPLPFQEILKRFRRKHDVAAMREEISVELHAFDCLHAPSADGGEDLLDAPFSDRHRRLRSVVDDASAVSEVLVTDDADEIAAFEATALEGGHEGIMLKNPAAPYTPGDRGKDWLKRKPDVETLDLVVTGAEWGEGRRASVLGTFLLSARDAAGDGFETIGKVATGLTDEELAALSDRLEPHVRSEDGQTVDIEPAVVLEVGYEEIQASPTYSSGYALRFPRFVSVREDKTPTTADTIERVERLAAQQQQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE004437
EMBL· GenBank· DDBJ
AAG19323.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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