Q9HNX6 · MPTA_HALSA
- ProteinGTP cyclohydrolase MptA
- GenemptA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids311 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
Catalytic activity
- GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + formate + diphosphate + H+
Cofactor
Note: Binds 1 Fe2+ ion per subunit.
Pathway
Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 158 | May be catalytically important | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | GTP cyclohydrolase activity | |
Molecular Function | GTP cyclohydrolase I activity | |
Molecular Function | GTP cyclohydrolase IV activity | |
Molecular Function | iron ion binding | |
Biological Process | tetrahydromethanopterin biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGTP cyclohydrolase MptA
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Halobacteriaceae > Halobacterium > Halobacterium salinarum NRC-34001
Accessions
- Primary accessionQ9HNX6
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000147741 | 1-311 | GTP cyclohydrolase MptA | |||
Sequence: MSQQLPDVQATEPDVSVGLSEVGVTGVEKLVEIAREDDRPIVLMAEFEVYVDLPRGRKGIDMSRNMRVIDETLEDAVREPIYRVEEMCGEVAERLLEKHDYTTTATVEMNAELMLREETPASDLPTQGTIDIIASATAQEDAPTREEIGARVVGMTVCPCSQQMMSETARRKLAELGVGEDAVREFLRDVPQAGHSQRGHATLTVEAGGDPDVNLMDLVSVARDSMSARIYNTAKRPDEDHMTYESHANAKFVEDCVRSMARGVVEEFDHLPEDAVVTMKQSNDESIHQHNAHAERVAEFGQLREEVGSGE |
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length311
- Mass (Da)34,439
- Last updated2001-03-01 v1
- ChecksumF1F4109854921078
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE004437 EMBL· GenBank· DDBJ | AAG20094.1 EMBL· GenBank· DDBJ | Genomic DNA |