Q9HL99 · SYT_THEAC

Function

function

Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site.

166050100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site318Zn2+ (UniProtKB | ChEBI)
Binding site369Zn2+ (UniProtKB | ChEBI)
Binding site531Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionaminoacyl-tRNA editing activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionthreonine-tRNA ligase activity
Molecular FunctiontRNA binding
Biological Processthreonyl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Threonine--tRNA ligase
  • EC number
  • Alternative names
    • Threonyl-tRNA synthetase
      (ThrRS
      )

Gene names

    • Name
      thrS
    • Ordered locus names
      Ta0330

Organism names

Accessions

  • Primary accession
    Q9HL99

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001011151-660Threonine--tRNA ligase

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain1-49TGS
Region225-554Catalytic

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    660
  • Mass (Da)
    76,106
  • Last updated
    2001-03-01 v1
  • MD5 Checksum
    74EC45AD644267ACBCC4DDDCE7FB5A81
MPDSIVHVKKGQRFLDVIKDKNVVAVKIDSVLHDLRDVAERDVDAIPVSVYSDDGLYILRHSAAHLLANAVTNLYPDALPNTGPVVENGFYYDFDMKPIGEEDLAKIEDEMRRIQKENVPIERIVYQKADLLRIFAKNPYKIRIIEDNVSDASSVYRQGNFVDLCLGPHVPSTGYIKAFKLLNIASAVYKHDESKTLVRIYGTAFPDEKLLKQYLNNLEEAKRRDHRRIIAEMDLAVFNSEWAPGFPLYTQYGQTIRKELLSYMDSMNRKNGWFDVWTPHVFRDTIWKQSGHYAKYRPNMYLFTLPDGDSYGIKPMNCPGHIAIFSRRKYSYRDLPVRYSEPGTVYRYEKSGEVGGLTRPRAFTQDDGHAFLRMDQIGDEIRTLLTMVKDVFTILFGNIELSFDLSVIDRDHPENYLVSYVCRNCGYRIEGARGTDIECPVCHSHDLEPDLSVWDNATEQLRDALKSMGIEYKEYPGEAAFYGPKIDVHVKDAIGRMWQLSTIQLDFFMPVNFGLTYTNSEGKEDRVVMIHRAIYGSYERVMAILLEHYAGKLPTWLTPIQTYVVPISSNFDEYARHVHEELIRHGIRSEIDTSQETVSKKIKLIHPYRPAYIIVVGSKEMETNSVTARNREGKSKTYSLSEFIDVVKKEIEQRKVDQAF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL445064
EMBL· GenBank· DDBJ
CAC11475.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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