Q9HL35 · PYRDB_THEAC

Function

function

Catalyzes the conversion of dihydroorotate to orotate with NAD+ as electron acceptor.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD+ route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site21FMN (UniProtKB | ChEBI)
Binding site45substrate
Binding site45-46FMN (UniProtKB | ChEBI)
Binding site69-73substrate
Binding site125FMN (UniProtKB | ChEBI)
Binding site125substrate
Active site128Nucleophile
Binding site163FMN (UniProtKB | ChEBI)
Binding site187FMN (UniProtKB | ChEBI)
Binding site188-189substrate
Binding site213FMN (UniProtKB | ChEBI)
Binding site239-240FMN (UniProtKB | ChEBI)
Binding site261-262FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondihydroorotate dehydrogenase (NAD+) activity
Molecular FunctionNADP binding
Molecular Functionuracil binding
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processthymine catabolic process
Biological Processuracil catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
  • EC number
  • Short names
    DHOD B; DHODase B; DHOdehase B
  • Alternative names
    • Dihydroorotate oxidase B
    • Orotate reductase (NADH)

Gene names

    • Name
      pyrD
    • Ordered locus names
      Ta0404

Organism names

Accessions

  • Primary accession
    Q9HL35

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001484181-300Dihydroorotate dehydrogenase B (NAD+), catalytic subunit

Proteomic databases

Interaction

Subunit

Heterotetramer of 2 PyrK and 2 PyrD type B subunits.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    300
  • Mass (Da)
    32,057
  • Last updated
    2001-03-01 v1
  • Checksum
    68150404D7163E8D
MADLSTSVAGIRLENPLMLASGILDENGYTMLDVMNNGAAAVVTKSIGMEERNGYSAPVIVEYGDSLINAVGLSNPGIDNFAEEIRIAKRSGKPVIGSVFASDAESFVNLGRKMQEYGCDAVELNLSCPHVKGFGLEVGSDPDLVEDIVNEMKSKISVPVFAKLSPNVSDIIEIAKAAEKADAYVLINTVKAMKIDIRARMPVLTNAYGGLSGPAIKPVGVRYVYEVKKETGKDIIGVGGITTYEDAVEYIMAGASAVQIGTALYTVGKSVFRNIISQMNTFMDDEKFHSIQDMVGVAIR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL445064
EMBL· GenBank· DDBJ
CAC11547.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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