Q9HI41 · Q9HI41_THEAC
- ProteinProbable apurinic/apyrimidinic endonuclease
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids241 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Probably binds two magnesium or manganese ions per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 28 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Active site | 96 | ||||
Active site | 135 | Proton donor/acceptor | |||
Binding site | 135 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 137 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Site | 137 | Transition state stabilizer | |||
Site | 206 | Important for catalytic activity | |||
Binding site | 231 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Active site | 232 | Proton acceptor | |||
Binding site | 232 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Site | 232 | Interaction with DNA substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA binding | |
Molecular Function | DNA-(apurinic or apyrimidinic site) endonuclease activity | |
Molecular Function | double-stranded DNA 3'-5' DNA exonuclease activity | |
Molecular Function | endonuclease activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoric diester hydrolase activity | |
Biological Process | base-excision repair |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Candidatus Thermoplasmatota > Thermoplasmata > Thermoplasmatales > Thermoplasmataceae > Thermoplasma
Accessions
- Primary accessionQ9HI41
Proteomes
PTM/Processing
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 24-232 | Endonuclease/exonuclease/phosphatase | |||
Sequence similarities
Belongs to the DNA repair enzymes AP/ExoA family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length241
- Mass (Da)28,093
- Last updated2001-03-01 v1
- Checksum760A2ACF8F6A1293
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL445067 EMBL· GenBank· DDBJ | CAC12624.1 EMBL· GenBank· DDBJ | Genomic DNA |