Q9HI41 · Q9HI41_THEAC

Function

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site, site.

124120406080100120140160180200220240
Type
IDPosition(s)Description
Binding site28Mg2+ 1 (UniProtKB | ChEBI)
Active site96
Active site135Proton donor/acceptor
Binding site135Mg2+ 1 (UniProtKB | ChEBI)
Binding site137Mg2+ 1 (UniProtKB | ChEBI)
Site137Transition state stabilizer
Site206Important for catalytic activity
Binding site231Mg2+ 1 (UniProtKB | ChEBI)
Active site232Proton acceptor
Binding site232Mg2+ 1 (UniProtKB | ChEBI)
Site232Interaction with DNA substrate

GO annotations

AspectTerm
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Molecular Functionphosphoric diester hydrolase activity
Biological Processbase-excision repair

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Probable apurinic/apyrimidinic endonuclease

Gene names

    • Ordered locus names
      Ta1506

Organism names

Accessions

  • Primary accession
    Q9HI41

Proteomes

PTM/Processing

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-232Endonuclease/exonuclease/phosphatase

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    241
  • Mass (Da)
    28,093
  • Last updated
    2001-03-01 v1
  • Checksum
    760A2ACF8F6A1293
MNGLRAAVKNGAVSVFKQDDYFGIALQETKADSTSVPEEMYHLGYYLYNNPAKKKGYSGTMSLVREKPIDVSYGFENEEGRILNLEFDKFYFINVYFPNAQHGLTRLDMKLDFDEKFLEYSNELRKKKPLIICGDFNVAHEEIDIARPKDNENNAGFTKQERDWMTKFLDSGYVDTYRIFMKEGGHYSWWSYRFNARAKNIGWRIDYFVVSDDIRDRVKKAEILETVTGSDHAPVTLEVDL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL445067
EMBL· GenBank· DDBJ
CAC12624.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp