Q9HG11 · MPKC_EMENI
- ProteinMitogen-activated protein kinase mpkC
- GenempkC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids415 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source.
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Activity regulation
Activated by tyrosine and threonine phosphorylation.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | MAP kinase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | cellular hyperosmotic response | |
Biological Process | cellular response to oxidative stress | |
Biological Process | osmosensory signaling pathway | |
Biological Process | p38MAPK cascade | |
Biological Process | protein phosphorylation | |
Biological Process | stress-activated MAPK cascade |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMitogen-activated protein kinase mpkC
- EC number
- Short namesMAP kinase C
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Nidulantes
Accessions
- Primary accessionQ9HG11
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000289717 | 1-415 | Mitogen-activated protein kinase mpkC | |||
Sequence: MAEFIRSDILGTTFETTSRYANLQPVGLGTAGVVCSAYDLISEQVVAIKKMMKPFHSTSVAKRTYREVKLLRHLRHDNLINMSDIFISPLEDVYLVTELLGTDLHRLLNGKPLESKFAQYFTYQILRGLKYIHSAGVIHRDLKPGNLLINENCDLKICDFGLARVQEPQMTGYVSTRYYRAPEIMLTWQRYGSKVDLWSVGCILAEMLLGRPLFPGTDHINQFWLITDLLGNPPDEVIDRITTNNTRRVVKSMAKRNPRPLKEILPAAEDAALNLLDNLLVFDPDRRISAEQGLMHPWMAPYHDPTDEPVATEQFDWSFNDADLPLDTWKIMIYSEVLDFFQLTTNAEPSGEQSQNQSQSQSQAFTSSQDLQLASMLNLGEGELLPDFAATIDPNKFGSVDYLMDGQSLDPNSFS | ||||||
Modified residue | 171 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 173 | Phosphotyrosine | ||||
Sequence: Y |
Post-translational modification
Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme.
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 20-299 | Protein kinase | ||||
Sequence: YANLQPVGLGTAGVVCSAYDLISEQVVAIKKMMKPFHSTSVAKRTYREVKLLRHLRHDNLINMSDIFISPLEDVYLVTELLGTDLHRLLNGKPLESKFAQYFTYQILRGLKYIHSAGVIHRDLKPGNLLINENCDLKICDFGLARVQEPQMTGYVSTRYYRAPEIMLTWQRYGSKVDLWSVGCILAEMLLGRPLFPGTDHINQFWLITDLLGNPPDEVIDRITTNNTRRVVKSMAKRNPRPLKEILPAAEDAALNLLDNLLVFDPDRRISAEQGLMHPWM | ||||||
Motif | 171-173 | TXY | ||||
Sequence: TGY |
Domain
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Sequence similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length415
- Mass (Da)46,990
- Last updated2007-01-09 v2
- Checksum9EB7A07F88F66FF8
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF195773 EMBL· GenBank· DDBJ | AAG28463.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF137429 EMBL· GenBank· DDBJ | ABL85065.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ402476 EMBL· GenBank· DDBJ | ABD64614.1 EMBL· GenBank· DDBJ | mRNA | ||
AACD01000080 EMBL· GenBank· DDBJ | EAA60710.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
BN001303 EMBL· GenBank· DDBJ | CBF77037.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |