Q9HG11 · MPKC_EMENI

Function

function

Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Activated by tyrosine and threonine phosphorylation.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site26-34ATP (UniProtKB | ChEBI)
Binding site49ATP (UniProtKB | ChEBI)
Active site141Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionMAP kinase activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processcellular hyperosmotic response
Biological Processcellular response to oxidative stress
Biological Processosmosensory signaling pathway
Biological Processp38MAPK cascade
Biological Processprotein phosphorylation
Biological Processstress-activated MAPK cascade

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitogen-activated protein kinase mpkC
  • EC number
  • Short names
    MAP kinase C

Gene names

    • Name
      mpkC
    • ORF names
      AN4668

Organism names

Accessions

  • Primary accession
    Q9HG11
  • Secondary accessions
    • C8VB11
    • Q208R0
    • Q5B462

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002897171-415Mitogen-activated protein kinase mpkC
Modified residue171Phosphothreonine
Modified residue173Phosphotyrosine

Post-translational modification

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme.

Keywords

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain20-299Protein kinase
Motif171-173TXY

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    415
  • Mass (Da)
    46,990
  • Last updated
    2007-01-09 v2
  • Checksum
    9EB7A07F88F66FF8
MAEFIRSDILGTTFETTSRYANLQPVGLGTAGVVCSAYDLISEQVVAIKKMMKPFHSTSVAKRTYREVKLLRHLRHDNLINMSDIFISPLEDVYLVTELLGTDLHRLLNGKPLESKFAQYFTYQILRGLKYIHSAGVIHRDLKPGNLLINENCDLKICDFGLARVQEPQMTGYVSTRYYRAPEIMLTWQRYGSKVDLWSVGCILAEMLLGRPLFPGTDHINQFWLITDLLGNPPDEVIDRITTNNTRRVVKSMAKRNPRPLKEILPAAEDAALNLLDNLLVFDPDRRISAEQGLMHPWMAPYHDPTDEPVATEQFDWSFNDADLPLDTWKIMIYSEVLDFFQLTTNAEPSGEQSQNQSQSQSQAFTSSQDLQLASMLNLGEGELLPDFAATIDPNKFGSVDYLMDGQSLDPNSFS

Sequence caution

The sequence CBF77037.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence EAA60710.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF195773
EMBL· GenBank· DDBJ
AAG28463.2
EMBL· GenBank· DDBJ
Genomic DNA
EF137429
EMBL· GenBank· DDBJ
ABL85065.1
EMBL· GenBank· DDBJ
mRNA
DQ402476
EMBL· GenBank· DDBJ
ABD64614.1
EMBL· GenBank· DDBJ
mRNA
AACD01000080
EMBL· GenBank· DDBJ
EAA60710.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
BN001303
EMBL· GenBank· DDBJ
CBF77037.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp