Q9HDB5 · NRX3B_HUMAN
- ProteinNeurexin-3-beta
- GeneNRXN3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids637 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell projection | |
Cellular Component | plasma membrane | |
Cellular Component | presynaptic membrane | |
Molecular Function | cell adhesion molecule binding | |
Molecular Function | metal ion binding | |
Molecular Function | neuroligin family protein binding | |
Molecular Function | transmembrane signaling receptor activity | |
Biological Process | adult behavior | |
Biological Process | angiogenesis | |
Biological Process | learning | |
Biological Process | neuron cell-cell adhesion | |
Biological Process | signal transduction | |
Biological Process | social behavior | |
Biological Process | vocalization behavior |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNeurexin-3-beta
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9HDB5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 36-562 | Extracellular | ||||
Sequence: SSNVASSSSTSSSPGSHSQHEHHFHGSKHHSVPISIYRSPVSLRGGHAGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTDDEDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESSSTT | ||||||
Transmembrane | 563-583 | Helical | ||||
Sequence: GMVVGIVAAAALCILILLYAM | ||||||
Topological domain | 584-637 | Cytoplasmic | ||||
Sequence: YKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 805 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-35 | |||||
Sequence: MHLRIHARRSPPRRPAWTLGIWFLFWGCIVSSVWS | ||||||
Chain | PRO_0000412543 | 36-550 | Neurexin-3-beta, soluble form | |||
Sequence: SSNVASSSSTSSSPGSHSQHEHHFHGSKHHSVPISIYRSPVSLRGGHAGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTDDEDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPG | ||||||
Chain | PRO_0000019502 | 36-637 | Neurexin-3-beta | |||
Sequence: SSNVASSSSTSSSPGSHSQHEHHFHGSKHHSVPISIYRSPVSLRGGHAGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTDDEDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV | ||||||
Glycosylation | 184 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 252 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 296 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 312 | O-linked (Xyl...) (heparan sulfate) serine | ||||
Sequence: S | ||||||
Chain | PRO_0000412544 | 551-637 | Neurexin-3-beta, C-terminal fragment | |||
Sequence: ASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV |
Post-translational modification
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Subunit
Very weak binding, if any, with CBLN4 (By similarity).
Specific isoforms bind neuroligins NLGN1, NLGN2 and NLGN3 (By similarity).
Interacts with CLSTN3 (By similarity).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9HDB5-2 | PAX4 Q3KNR5 | 3 | EBI-18040962, EBI-10240813 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 43-65 | Disordered | ||||
Sequence: SSTSSSPGSHSQHEHHFHGSKHH | ||||||
Domain | 85-255 | Laminin G-like | ||||
Sequence: ATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSV | ||||||
Region | 289-310 | Disordered | ||||
Sequence: ATTTTRKNRSTASIQPTSDDLV | ||||||
Region | 605-637 | Disordered | ||||
Sequence: NSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV | ||||||
Compositional bias | 619-637 | Basic and acidic residues | ||||
Sequence: QSSKSGHKKQKNKDREYYV |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 7 isoforms produced by Alternative promoter usage & Alternative splicing. A number of isoforms, alpha-type and beta-type, are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. Additional isoforms produced by alternative splicing seem to exist.
Q9HDB5-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1b
- Length637
- Mass (Da)69,305
- Last updated2008-12-16 v4
- ChecksumA0F100DA9D72A149
Q9HDB5-2
- Name2b
- NoteProduced by alternative splicing.
Q9HDB5-3
- Name3b
- NoteProduced by alternative splicing.
Q9HDB5-4
- Name4b
- NoteProduced by alternative splicing.
Q9Y4C0-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name1a
Q9Y4C0-3
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name3a
Q9Y4C0-4
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name4a
Computationally mapped potential isoform sequences
There are 10 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9Y4C0 | NRX3A_HUMAN | NRXN3 | 1643 | ||
A0A0U1RQC5 | A0A0U1RQC5_HUMAN | NRXN3 | 1468 | ||
A0A0U1RRJ0 | A0A0U1RRJ0_HUMAN | NRXN3 | 1328 | ||
H0YJL2 | H0YJL2_HUMAN | NRXN3 | 174 | ||
G3V4R9 | G3V4R9_HUMAN | NRXN3 | 75 | ||
G3V247 | G3V247_HUMAN | NRXN3 | 119 | ||
A0A0A0MR89 | A0A0A0MR89_HUMAN | NRXN3 | 1571 | ||
A0A7I2YQT0 | A0A7I2YQT0_HUMAN | NRXN3 | 366 | ||
A0A0C4DGK4 | A0A0C4DGK4_HUMAN | NRXN3 | 398 | ||
A0A7I2V2B1 | A0A7I2V2B1_HUMAN | NRXN3 | 670 |
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_035644 | 200 | in isoform 3b and isoform 4b | |||
Sequence: T → TGNTDNERFQMVKQKIPFKYNRPVEEWLQEK | ||||||
Alternative sequence | VSP_036465 | 328 | in isoform 2b | |||
Sequence: S → ST | ||||||
Alternative sequence | VSP_035646 | 329-367 | in isoform 3b | |||
Sequence: TGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTI → GRSARSSNAARSLRAALTWTWRLTYTFTPIIFISCVVH | ||||||
Alternative sequence | VSP_040988 | 329-536 | in isoform 4b | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_036466 | 329-537 | in isoform 2b | |||
Sequence: TGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTDDEDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPT → GRS | ||||||
Alternative sequence | VSP_035647 | 368-637 | in isoform 3b | |||
Sequence: Missing | ||||||
Compositional bias | 619-637 | Basic and acidic residues | ||||
Sequence: QSSKSGHKKQKNKDREYYV |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ493127 EMBL· GenBank· DDBJ | CAD37989.1 EMBL· GenBank· DDBJ | mRNA | ||
AF123462 EMBL· GenBank· DDBJ | AAD13621.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK056530 EMBL· GenBank· DDBJ | BAG51739.1 EMBL· GenBank· DDBJ | mRNA | ||
AL833739 EMBL· GenBank· DDBJ | CAH56254.1 EMBL· GenBank· DDBJ | mRNA | ||
AC008056 EMBL· GenBank· DDBJ | AAF09143.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC012099 EMBL· GenBank· DDBJ | AAF15058.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC018514 EMBL· GenBank· DDBJ | AAF99808.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471061 EMBL· GenBank· DDBJ | EAW81313.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471061 EMBL· GenBank· DDBJ | EAW81315.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC059368 EMBL· GenBank· DDBJ | AAH59368.1 EMBL· GenBank· DDBJ | mRNA | ||
BC068469 EMBL· GenBank· DDBJ | AAH68469.1 EMBL· GenBank· DDBJ | mRNA | ||
BC142649 EMBL· GenBank· DDBJ | AAI42650.1 EMBL· GenBank· DDBJ | mRNA | ||
BC150194 EMBL· GenBank· DDBJ | AAI50195.1 EMBL· GenBank· DDBJ | mRNA |