Q9HDB5 · NRX3B_HUMAN

  • Protein
    Neurexin-3-beta
  • Gene
    NRXN3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity).

Features

Showing features for binding site.

163750100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site137Ca2+ (UniProtKB | ChEBI)
Binding site154Ca2+ (UniProtKB | ChEBI)
Binding site206Ca2+ (UniProtKB | ChEBI)
Binding site208Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell projection
Cellular Componentplasma membrane
Cellular Componentpresynaptic membrane
Molecular Functioncell adhesion molecule binding
Molecular Functionmetal ion binding
Molecular Functionneuroligin family protein binding
Molecular Functiontransmembrane signaling receptor activity
Biological Processadult behavior
Biological Processangiogenesis
Biological Processlearning
Biological Processneuron cell-cell adhesion
Biological Processsignal transduction
Biological Processsocial behavior
Biological Processvocalization behavior

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      NRXN3
    • Synonyms
      KIAA0743

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9HDB5
  • Secondary accessions
    • A5PKW8
    • A8MPU5
    • B3KPM7
    • Q6NUR0
    • Q8IUD8

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain36-562Extracellular
Transmembrane563-583Helical
Topological domain584-637Cytoplasmic

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 805 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-35
ChainPRO_000041254336-550Neurexin-3-beta, soluble form
ChainPRO_000001950236-637Neurexin-3-beta
Glycosylation184N-linked (GlcNAc...) asparagine
Glycosylation252N-linked (GlcNAc...) asparagine
Glycosylation296N-linked (GlcNAc...) asparagine
Glycosylation312O-linked (Xyl...) (heparan sulfate) serine
ChainPRO_0000412544551-637Neurexin-3-beta, C-terminal fragment

Post-translational modification

Proccessed by alpha-secretase leading to the formation of an extracellular soluble protein as well as a C-terminal membrane-embedded fragment (CTF). Proteolysis of these CTFs by gamma-secretase releases intracellular domains (ICDs) and extracellular peptides.
O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the blood vessel walls (at protein level).

Gene expression databases

Organism-specific databases

Interaction

Subunit

Weakly interacts with CBLN1 and CBLN2 (By similarity).
Very weak binding, if any, with CBLN4 (By similarity).
Specific isoforms bind neuroligins NLGN1, NLGN2 and NLGN3 (By similarity).
Interacts with CLSTN3 (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9HDB5-2PAX4 Q3KNR53EBI-18040962, EBI-10240813

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region43-65Disordered
Domain85-255Laminin G-like
Region289-310Disordered
Region605-637Disordered
Compositional bias619-637Basic and acidic residues

Sequence similarities

Belongs to the neurexin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (7)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 7 isoforms produced by Alternative promoter usage & Alternative splicing. A number of isoforms, alpha-type and beta-type, are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. Additional isoforms produced by alternative splicing seem to exist.

Q9HDB5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    637
  • Mass (Da)
    69,305
  • Last updated
    2008-12-16 v4
  • Checksum
    A0F100DA9D72A149
MHLRIHARRSPPRRPAWTLGIWFLFWGCIVSSVWSSSNVASSSSTSSSPGSHSQHEHHFHGSKHHSVPISIYRSPVSLRGGHAGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTDDEDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV

Q9HDB5-2

  • Name
    2b
  • Note
    Produced by alternative splicing.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 328-328: S → ST
    • 329-537: TGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTDDEDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPT → GRS

Q9HDB5-3

  • Name
    3b
  • Note
    Produced by alternative splicing.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 200-200: T → TGNTDNERFQMVKQKIPFKYNRPVEEWLQEK
    • 329-367: TGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTI → GRSARSSNAARSLRAALTWTWRLTYTFTPIIFISCVVH
    • 368-637: Missing

Q9HDB5-4

  • Name
    4b
  • Note
    Produced by alternative splicing.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9Y4C0-1

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

Q9Y4C0-3

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

Q9Y4C0-4

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

Computationally mapped potential isoform sequences

There are 10 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q9Y4C0NRX3A_HUMANNRXN31643
A0A0U1RQC5A0A0U1RQC5_HUMANNRXN31468
A0A0U1RRJ0A0A0U1RRJ0_HUMANNRXN31328
H0YJL2H0YJL2_HUMANNRXN3174
G3V4R9G3V4R9_HUMANNRXN375
G3V247G3V247_HUMANNRXN3119
A0A0A0MR89A0A0A0MR89_HUMANNRXN31571
A0A7I2YQT0A0A7I2YQT0_HUMANNRXN3366
A0A0C4DGK4A0A0C4DGK4_HUMANNRXN3398
A0A7I2V2B1A0A7I2V2B1_HUMANNRXN3670

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_035644200in isoform 3b and isoform 4b
Alternative sequenceVSP_036465328in isoform 2b
Alternative sequenceVSP_035646329-367in isoform 3b
Alternative sequenceVSP_040988329-536in isoform 4b
Alternative sequenceVSP_036466329-537in isoform 2b
Alternative sequenceVSP_035647368-637in isoform 3b
Compositional bias619-637Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ493127
EMBL· GenBank· DDBJ
CAD37989.1
EMBL· GenBank· DDBJ
mRNA
AF123462
EMBL· GenBank· DDBJ
AAD13621.1
EMBL· GenBank· DDBJ
Genomic DNA
AK056530
EMBL· GenBank· DDBJ
BAG51739.1
EMBL· GenBank· DDBJ
mRNA
AL833739
EMBL· GenBank· DDBJ
CAH56254.1
EMBL· GenBank· DDBJ
mRNA
AC008056
EMBL· GenBank· DDBJ
AAF09143.1
EMBL· GenBank· DDBJ
Genomic DNA
AC012099
EMBL· GenBank· DDBJ
AAF15058.1
EMBL· GenBank· DDBJ
Genomic DNA
AC018514
EMBL· GenBank· DDBJ
AAF99808.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471061
EMBL· GenBank· DDBJ
EAW81313.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471061
EMBL· GenBank· DDBJ
EAW81315.1
EMBL· GenBank· DDBJ
Genomic DNA
BC059368
EMBL· GenBank· DDBJ
AAH59368.1
EMBL· GenBank· DDBJ
mRNA
BC068469
EMBL· GenBank· DDBJ
AAH68469.1
EMBL· GenBank· DDBJ
mRNA
BC142649
EMBL· GenBank· DDBJ
AAI42650.1
EMBL· GenBank· DDBJ
mRNA
BC150194
EMBL· GenBank· DDBJ
AAI50195.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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