Q9HCQ7 · NPVF_HUMAN

  • Protein
    Pro-FMRFamide-related neuropeptide VF
  • Gene
    NPVF
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Neuropeptide RFRP-1

Efficiently inhibits forskolin-induced production of cAMP. Acts as a potent negative regulator of gonadotropin synthesis and secretion (PubMed:11025660, PubMed:20027225).
Induces secretion of prolactin (By similarity).

Neuropeptide NPVF

Efficiently inhibits forskolin-induced production of cAMP. Blocks morphine-induced analgesia.

Neuropeptide RFRP-2

Shows no inhibitory activity of forskolin-induced production of cAMP.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionsignaling receptor binding
Biological Processnegative regulation of gonadotropin secretion
Biological Processneuropeptide signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      NPVF
    • Synonyms
      C7orf9, RFRP

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9HCQ7
  • Secondary accessions
    • A4D164
    • Q7LE27
    • Q96PI9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_01407332in dbSNP:rs886354
Natural variantVAR_01407442in dbSNP:rs877834
Natural variantVAR_030644121in dbSNP:rs3213641

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 281 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, propeptide, peptide, modified residue.

TypeIDPosition(s)Description
Signal1-26
PropeptidePRO_000000992027-55
PeptidePRO_000000992156-92Neuropeptide NPSF
PeptidePRO_000040117181-92Neuropeptide RFRP-1
Modified residue92Phenylalanine amide
PropeptidePRO_000000992295-99
PeptidePRO_0000009923101-112Neuropeptide RFRP-2
PropeptidePRO_0000009924115-121
PeptidePRO_0000009925124-131Neuropeptide NPVF
Modified residue131Phenylalanine amide
PropeptidePRO_0000009926134-196

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 1

Specifically expressed in the retina.

Neuropeptide RFRP-1

Detected in the hypothalamus.

Neuropeptide NPVF

Detected in the hypothalamus.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9HCQ7SGTA O437653EBI-1753111, EBI-347996
BINARY Q9HCQ7UBQLN2 Q9UHD93EBI-1753111, EBI-947187

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

Q9HCQ7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    196
  • Mass (Da)
    22,327
  • Last updated
    2022-02-23 v3
  • Checksum
    332248B927702198
MEIISSKLFILLTLATSSLLTSNIFCADELVMSNLHSKENYDKYSEPRGYPKGERSLNFEELKDWGPKNVIKMSTPAVNKMPHSFANLPLRFGRNVQEERSAGATANLPLRSGRNMEVSLVRRVPNLPQRFGRTTTAKSVCRMLSDLCQGSMHSPCANDLFYSMTCQHQEIQNPDQKQSRRLLFKKIDDAELKQEK

Q9HCQ7-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_039962181-196in isoform 2

Mass Spectrometry

Neuropeptide RFRP-1

Molecular mass is 1,428.85 Da. Determined by MALDI.

Neuropeptide NPVF

Molecular mass is 969.56 Da. Determined by MALDI.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB040290
EMBL· GenBank· DDBJ
BAB17674.1
EMBL· GenBank· DDBJ
mRNA
AF330057
EMBL· GenBank· DDBJ
AAK94201.1
EMBL· GenBank· DDBJ
mRNA
AF440392
EMBL· GenBank· DDBJ
AAL90453.1
EMBL· GenBank· DDBJ
mRNA
AF440395
EMBL· GenBank· DDBJ
AAL90458.1
EMBL· GenBank· DDBJ
Genomic DNA
AF440393
EMBL· GenBank· DDBJ
AAL90458.1
EMBL· GenBank· DDBJ
Genomic DNA
AF440394
EMBL· GenBank· DDBJ
AAL90458.1
EMBL· GenBank· DDBJ
Genomic DNA
AC004129
EMBL· GenBank· DDBJ
AAP22339.1
EMBL· GenBank· DDBJ
Genomic DNA
CH236948
EMBL· GenBank· DDBJ
EAL24237.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471073
EMBL· GenBank· DDBJ
EAW93830.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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