CHD8 promotes the association of beta-catenin and histone H1 with formation of the trimeric complex on chromatin being required for inhibition of beta-catenin-dependent transactivation.
This study provides evidence of a novel interaction between BRCA1 and beta-catenin and that loss of BRCA1 leads to impaired expression of the nuclear form of beta-catenin which may contribute to the pathogenesis of breast cancer.
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