Q9HC58 · NCKX3_HUMAN
- ProteinSodium/potassium/calcium exchanger 3
- GeneSLC24A3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids644 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Calcium, potassium:sodium antiporter that transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.
Catalytic activity
- Ca2+(out) + K+(out) + 4 Na+(in) = Ca2+(in) + K+(in) + 4 Na+(out)Ca2+ (out)CHEBI:29108
+ K+ (out)CHEBI:29103+ 4 Na+ (in)CHEBI:29101= Ca2+ (in)CHEBI:29108+ K+ (in)CHEBI:29103+ 4 Na+ (out)CHEBI:29101
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell periphery | |
Cellular Component | plasma membrane | |
Molecular Function | calcium channel activity | |
Molecular Function | calcium, potassium:sodium antiporter activity | |
Molecular Function | symporter activity | |
Biological Process | bone mineralization | |
Biological Process | calcium ion transmembrane transport | |
Biological Process | intracellular calcium ion homeostasis | |
Biological Process | monoatomic ion transport | |
Biological Process | negative regulation of gene expression | |
Biological Process | positive regulation of gene expression | |
Biological Process | potassium ion transmembrane transport | |
Biological Process | sodium ion transmembrane transport | |
Biological Process | transport across blood-brain barrier |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSodium/potassium/calcium exchanger 3
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9HC58
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 45-107 | Extracellular | ||||
Sequence: EQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQ | ||||||
Transmembrane | 108-128 | Helical | ||||
Sequence: GAVVLHVLCAIYMFYALAIVC | ||||||
Topological domain | 129-153 | Cytoplasmic | ||||
Sequence: DDFFVPSLEKICERLHLSEDVAGAT | ||||||
Transmembrane | 154-174 | Helical | ||||
Sequence: FMAAGSSAPELFTSVIGVFIT | ||||||
Topological domain | 175-182 | Extracellular | ||||
Sequence: KGDVGVGT | ||||||
Transmembrane | 183-203 | Helical | ||||
Sequence: IVGSAVFNILCIIGVCGLFAG | ||||||
Topological domain | 204-210 | Cytoplasmic | ||||
Sequence: QVVALSS | ||||||
Transmembrane | 211-231 | Helical | ||||
Sequence: WCLLRDSIYYTLSVIALIVFI | ||||||
Topological domain | 232-234 | Extracellular | ||||
Sequence: YDE | ||||||
Transmembrane | 235-255 | Helical | ||||
Sequence: KVSWWESLVLVLMYLIYIVIM | ||||||
Topological domain | 256-484 | Cytoplasmic | ||||
Sequence: KYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASST | ||||||
Transmembrane | 485-505 | Helical | ||||
Sequence: LWIAAFSYMMVWMVTIIGYTL | ||||||
Topological domain | 506-510 | Extracellular | ||||
Sequence: GIPDV | ||||||
Transmembrane | 511-531 | Helical | ||||
Sequence: IMGITFLAAGTSVPDCMASLI | ||||||
Topological domain | 532-549 | Cytoplasmic | ||||
Sequence: VARQGMGDMAVSNSIGSN | ||||||
Transmembrane | 550-570 | Helical | ||||
Sequence: VFDILIGLGLPWALQTLAVDY | ||||||
Topological domain | 571-580 | Extracellular | ||||
Sequence: GSYIRLNSRG | ||||||
Transmembrane | 581-601 | Helical | ||||
Sequence: LIYSVGLLLASVFVTVFGVHL | ||||||
Topological domain | 602-615 | Cytoplasmic | ||||
Sequence: NKWQLDKKLGCGCL | ||||||
Transmembrane | 616-636 | Helical | ||||
Sequence: LLYGVFLCFSIMTEFNVFTFV | ||||||
Topological domain | 637-644 | Extracellular | ||||
Sequence: NLPMCGDH |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_028024 | 49 | in dbSNP:rs3790174 | |||
Sequence: L → P | ||||||
Natural variant | VAR_028025 | 55 | in dbSNP:rs1569767 | |||
Sequence: V → I | ||||||
Natural variant | VAR_028026 | 168 | in dbSNP:rs3790267 | |||
Sequence: V → I | ||||||
Natural variant | VAR_028027 | 271 | in dbSNP:rs6136807 | |||
Sequence: G → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 642 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Signal | 1-44 | UniProt | |||||
Sequence: MRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLR | |||||||
Chain | PRO_0000019370 | 45-644 | UniProt | Sodium/potassium/calcium exchanger 3 | |||
Sequence: EQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMCGDH | |||||||
Glycosylation | 71 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 86 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue | 308 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 308 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for repeat, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 149-189 | Alpha-1 | ||||
Sequence: VAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVF | ||||||
Region | 405-442 | Disordered | ||||
Sequence: AEAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTPS | ||||||
Compositional bias | 408-435 | Acidic residues | ||||
Sequence: GNETENENEDNENDEEEEEDEDDDEGPY | ||||||
Repeat | 518-549 | Alpha-2 | ||||
Sequence: AAGTSVPDCMASLIVARQGMGDMAVSNSIGSN |
Sequence similarities
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length644
- Mass (Da)71,992
- Last updated2006-10-17 v4
- Checksum84247571AC2EEE7B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 408-435 | Acidic residues | ||||
Sequence: GNETENENEDNENDEEEEEDEDDDEGPY |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF288087 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
AF169257 EMBL· GenBank· DDBJ | AAG12988.2 EMBL· GenBank· DDBJ | mRNA | ||
AL121830 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL049647 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL034425 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL121761 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL139429 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL136090 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |