Q9HB63 · NET4_HUMAN
- ProteinNetrin-4
- GeneNTN4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids628 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | laminin complex | |
Cellular Component | plasma membrane | |
Molecular Function | laminin-1 binding | |
Biological Process | animal organ morphogenesis | |
Biological Process | axon guidance | |
Biological Process | basement membrane assembly | |
Biological Process | cell migration | |
Biological Process | neuron remodeling | |
Biological Process | regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling | |
Biological Process | substrate adhesion-dependent cell spreading | |
Biological Process | tissue development |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNetrin-4
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9HB63
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Major component.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_023548 | 205 | in dbSNP:rs17288108 | |||
Sequence: Y → H |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 623 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MGSCARLLLLWGCTVVAA | ||||||
Chain | PRO_0000042116 | 19-628 | Netrin-4 | |||
Sequence: GLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRPCDCAGSCDPITGDCISSHTDIDWYHEVPDFRPVHNKSEPAWEWEDAQGFSALLHSGKCECKEQTLGNAKAFCGMKYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIFRGKRTLYPESWTDRGCTCPILNPGLEYLVAGHEDIRTGKLIVNMKSFVQHWKPSLGRKVMDILKRECK | ||||||
Glycosylation | 56 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 163 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 262↔271 | |||||
Sequence: CFCNGHADQC | ||||||
Disulfide bond | 264↔293 | |||||
Sequence: CNGHADQCIPVHGFRPVKAPGTFHMVHGKC | ||||||
Disulfide bond | 295↔304 | |||||
Sequence: CKHNTAGSHC | ||||||
Disulfide bond | 307↔329 | |||||
Sequence: CAPLYNDRPWEAADGKTGAPNEC | ||||||
Disulfide bond | 332↔341 | |||||
Sequence: CKCNGHADTC | ||||||
Disulfide bond | 334↔359 | |||||
Sequence: CNGHADTCHFDVNVWEASGNRSGGVC | ||||||
Glycosylation | 353 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 362↔371 | |||||
Sequence: CQHNTEGQYC | ||||||
Disulfide bond | 374↔392 | |||||
Sequence: CKPGFYRDLRRPFSAPDAC | ||||||
Disulfide bond | 395↔413 | |||||
Sequence: CSCHPVGSAVLPANSVTFC | ||||||
Disulfide bond | 397↔420 | |||||
Sequence: CHPVGSAVLPANSVTFCDPSNGDC | ||||||
Disulfide bond | 422↔431 | |||||
Sequence: CKPGVAGRRC | ||||||
Disulfide bond | 434↔446 | |||||
Sequence: CMVGYWGFGDYGC | ||||||
Glycosylation | 483 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 506↔576 | |||||
Sequence: CECKEQTLGNAKAFCGMKYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIFRGKRTLYPESWTDRGC | ||||||
Disulfide bond | 520↔627 | |||||
Sequence: CGMKYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIFRGKRTLYPESWTDRGCTCPILNPGLEYLVAGHEDIRTGKLIVNMKSFVQHWKPSLGRKVMDILKREC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen.
Gene expression databases
Organism-specific databases
Interaction
Subunit
May form a homodimer.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9HB63 | CASK O14936-4 | 3 | EBI-743459, EBI-12007726 | |
BINARY | Q9HB63 | CYSRT1 A8MQ03 | 3 | EBI-743459, EBI-3867333 | |
BINARY | Q9HB63 | HOXA1 P49639 | 5 | EBI-743459, EBI-740785 | |
BINARY | Q9HB63 | KPRP Q5T749 | 3 | EBI-743459, EBI-10981970 | |
BINARY | Q9HB63 | KRTAP10-8 P60410 | 3 | EBI-743459, EBI-10171774 | |
BINARY | Q9HB63 | KRTAP21-2 Q3LI59 | 3 | EBI-743459, EBI-18395721 | |
BINARY | Q9HB63 | KRTAP5-9 P26371 | 4 | EBI-743459, EBI-3958099 | |
BINARY | Q9HB63 | LCE1C Q5T751 | 3 | EBI-743459, EBI-12224199 | |
BINARY | Q9HB63 | MEOX2 Q6FHY5 | 3 | EBI-743459, EBI-16439278 | |
BINARY | Q9HB63 | NOTCH2NLC P0DPK4 | 3 | EBI-743459, EBI-22310682 | |
BINARY | Q9HB63 | PECAM1 P16284 | 3 | EBI-743459, EBI-716404 | |
BINARY | Q9HB63-3 | KRTAP5-9 P26371 | 3 | EBI-10310092, EBI-3958099 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 30-261 | Laminin N-terminal | ||||
Sequence: CEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGS | ||||||
Domain | 262-331 | Laminin EGF-like 1 | ||||
Sequence: CFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRT | ||||||
Domain | 332-394 | Laminin EGF-like 2 | ||||
Sequence: CKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKP | ||||||
Domain | 395-448 | Laminin EGF-like 3 | ||||
Sequence: CSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRP | ||||||
Domain | 506-627 | NTR | ||||
Sequence: CECKEQTLGNAKAFCGMKYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIFRGKRTLYPESWTDRGCTCPILNPGLEYLVAGHEDIRTGKLIVNMKSFVQHWKPSLGRKVMDILKREC |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 3 isoforms produced by Alternative splicing.
Q9HB63-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length628
- Mass (Da)70,071
- Last updated2005-09-27 v2
- Checksum275613B63A39B267
Q9HB63-2
- Name2
- Differences from canonical
- 504-526: Missing
Q9HB63-3
- Name3
- SynonymsHetrin
- Differences from canonical
- 1-37: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F8W0I7 | F8W0I7_HUMAN | NTN4 | 176 | ||
A0A6I8PS14 | A0A6I8PS14_HUMAN | NTN4 | 624 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_015745 | 1-37 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 68 | in Ref. 1; AAG30822 | ||||
Sequence: T → K | ||||||
Sequence conflict | 161 | in Ref. 3; AAF69670 | ||||
Sequence: A → G | ||||||
Sequence conflict | 222 | in Ref. 4; AAP92113 | ||||
Sequence: T → I | ||||||
Sequence conflict | 331 | in Ref. 1 and 4 | ||||
Sequence: T → A | ||||||
Sequence conflict | 462 | in Ref. 4; AAP92113 | ||||
Sequence: C → R | ||||||
Sequence conflict | 472 | in Ref. 1; AAG30822 | ||||
Sequence: Y → C | ||||||
Sequence conflict | 472 | in Ref. 4; AAP92113 | ||||
Sequence: Y → H | ||||||
Alternative sequence | VSP_015746 | 504-526 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 545 | in Ref. 4; AAP92113 | ||||
Sequence: N → S |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF278532 EMBL· GenBank· DDBJ | AAG30822.1 EMBL· GenBank· DDBJ | mRNA | ||
AF297711 EMBL· GenBank· DDBJ | AAG53651.1 EMBL· GenBank· DDBJ | mRNA | ||
AF119916 EMBL· GenBank· DDBJ | AAF69670.2 EMBL· GenBank· DDBJ | mRNA | ||
AY330211 EMBL· GenBank· DDBJ | AAP92113.1 EMBL· GenBank· DDBJ | mRNA | ||
AL137540 EMBL· GenBank· DDBJ | CAB70800.3 EMBL· GenBank· DDBJ | mRNA | ||
CH471054 EMBL· GenBank· DDBJ | EAW97544.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC013591 EMBL· GenBank· DDBJ | AAH13591.2 EMBL· GenBank· DDBJ | mRNA | ||
BC136798 EMBL· GenBank· DDBJ | AAI36799.1 EMBL· GenBank· DDBJ | mRNA | ||
BC136799 EMBL· GenBank· DDBJ | AAI36800.1 EMBL· GenBank· DDBJ | mRNA | ||
AL833767 EMBL· GenBank· DDBJ | CAH56243.1 EMBL· GenBank· DDBJ | mRNA | ||
AK024691 EMBL· GenBank· DDBJ | BAB14964.1 EMBL· GenBank· DDBJ | mRNA |