Q9HB63 · NET4_HUMAN

  • Protein
    Netrin-4
  • Gene
    NTN4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentlaminin complex
Cellular Componentplasma membrane
Molecular Functionlaminin-1 binding
Biological Processanimal organ morphogenesis
Biological Processaxon guidance
Biological Processbasement membrane assembly
Biological Processcell migration
Biological Processneuron remodeling
Biological Processregulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling
Biological Processsubstrate adhesion-dependent cell spreading
Biological Processtissue development

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Netrin-4
  • Alternative names
    • Beta-netrin
    • Hepar-derived netrin-like protein

Gene names

    • Name
      NTN4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9HB63
  • Secondary accessions
    • B2RNC2
    • Q658K9
    • Q7L3F1
    • Q7L9D6
    • Q7Z5B6

Proteomes

Organism-specific databases

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_023548205in dbSNP:rs17288108

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 623 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000004211619-628Netrin-4
Glycosylation56N-linked (GlcNAc...) asparagine
Glycosylation163N-linked (GlcNAc...) asparagine
Disulfide bond262↔271
Disulfide bond264↔293
Disulfide bond295↔304
Disulfide bond307↔329
Disulfide bond332↔341
Disulfide bond334↔359
Glycosylation353N-linked (GlcNAc...) asparagine
Disulfide bond362↔371
Disulfide bond374↔392
Disulfide bond395↔413
Disulfide bond397↔420
Disulfide bond422↔431
Disulfide bond434↔446
Glycosylation483N-linked (GlcNAc...) asparagine
Disulfide bond506↔576
Disulfide bond520↔627

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen.

Gene expression databases

Organism-specific databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain30-261Laminin N-terminal
Domain262-331Laminin EGF-like 1
Domain332-394Laminin EGF-like 2
Domain395-448Laminin EGF-like 3
Domain506-627NTR

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 3 isoforms produced by Alternative splicing.

Q9HB63-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    628
  • Mass (Da)
    70,071
  • Last updated
    2005-09-27 v2
  • Checksum
    275613B63A39B267
MGSCARLLLLWGCTVVAAGLSGVAGVSSRCEKACNPRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQPKCDKCNAAYPHLAHLPSAMADSSFRFPRTWWQSAEDVHREKIQLDLEAEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLEDDVVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRPCDCAGSCDPITGDCISSHTDIDWYHEVPDFRPVHNKSEPAWEWEDAQGFSALLHSGKCECKEQTLGNAKAFCGMKYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIFRGKRTLYPESWTDRGCTCPILNPGLEYLVAGHEDIRTGKLIVNMKSFVQHWKPSLGRKVMDILKRECK

Q9HB63-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9HB63-3

  • Name
    3
  • Synonyms
    Hetrin
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F8W0I7F8W0I7_HUMANNTN4176
A0A6I8PS14A0A6I8PS14_HUMANNTN4624

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0157451-37in isoform 3
Sequence conflict68in Ref. 1; AAG30822
Sequence conflict161in Ref. 3; AAF69670
Sequence conflict222in Ref. 4; AAP92113
Sequence conflict331in Ref. 1 and 4
Sequence conflict462in Ref. 4; AAP92113
Sequence conflict472in Ref. 1; AAG30822
Sequence conflict472in Ref. 4; AAP92113
Alternative sequenceVSP_015746504-526in isoform 2
Sequence conflict545in Ref. 4; AAP92113

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF278532
EMBL· GenBank· DDBJ
AAG30822.1
EMBL· GenBank· DDBJ
mRNA
AF297711
EMBL· GenBank· DDBJ
AAG53651.1
EMBL· GenBank· DDBJ
mRNA
AF119916
EMBL· GenBank· DDBJ
AAF69670.2
EMBL· GenBank· DDBJ
mRNA
AY330211
EMBL· GenBank· DDBJ
AAP92113.1
EMBL· GenBank· DDBJ
mRNA
AL137540
EMBL· GenBank· DDBJ
CAB70800.3
EMBL· GenBank· DDBJ
mRNA
CH471054
EMBL· GenBank· DDBJ
EAW97544.1
EMBL· GenBank· DDBJ
Genomic DNA
BC013591
EMBL· GenBank· DDBJ
AAH13591.2
EMBL· GenBank· DDBJ
mRNA
BC136798
EMBL· GenBank· DDBJ
AAI36799.1
EMBL· GenBank· DDBJ
mRNA
BC136799
EMBL· GenBank· DDBJ
AAI36800.1
EMBL· GenBank· DDBJ
mRNA
AL833767
EMBL· GenBank· DDBJ
CAH56243.1
EMBL· GenBank· DDBJ
mRNA
AK024691
EMBL· GenBank· DDBJ
BAB14964.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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