Q9HB55 · CP343_HUMAN
- ProteinCytochrome P450 3A43
- GeneCYP3A43
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids503 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Exhibits low testosterone 6-beta-hydroxylase activity.
Miscellaneous
Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 or CYP3A5 exons, have been detected. All are possibly produced by trans-splicing. CYP3A43-CYP3A4 chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. CYP3A43-CYP3A5 chimeric transcripts exist in 2 different combinations: CYP3A43 exon 1 joined in frame to CYP3A5 exon 11-13 and CYP3A43 exon 1 joined in frame to CYP3A5 exon 12-13. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).
Catalytic activity
- an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH--hemoprotein reductase]
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | aromatase activity | |
Molecular Function | estrogen 16-alpha-hydroxylase activity | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Molecular Function | monooxygenase activity | |
Molecular Function | testosterone 6-beta-hydroxylase activity | |
Biological Process | cytochrome metabolic process | |
Biological Process | oxidative demethylation | |
Biological Process | steroid metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome P450 3A43
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9HB55
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Peripheral membrane protein
Microsome membrane ; Peripheral membrane protein
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_018050 | 25-88 | in allele CYP3A43*2 | |||
Sequence: YGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPD → LGPIHINFLRSWEFLGQPLCLFWELFCSTLGVFGILTENVMKNTEKCGGCMRGNSPCWSSWIPT | ||||||
Natural variant | VAR_048449 | 27 | in dbSNP:rs45558032 | |||
Sequence: T → A | ||||||
Natural variant | VAR_018051 | 89-503 | in allele CYP3A43*2 | |||
Sequence: Missing | ||||||
Natural variant | VAR_048450 | 145 | in dbSNP:rs45450092 | |||
Sequence: M → I | ||||||
Natural variant | VAR_048451 | 275 | in dbSNP:rs45621431 | |||
Sequence: M → I | ||||||
Natural variant | VAR_018052 | 340 | in allele CYP3A43*3; dbSNP:rs680055 | |||
Sequence: P → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 668 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000051814 | 1-503 | Cytochrome P450 3A43 | |||
Sequence: MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSGP |
Proteomic databases
PTM databases
Expression
Tissue specificity
Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.
Induction
By rifampicin.
Gene expression databases
Organism-specific databases
Structure
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
Q9HB55-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length503
- Mass (Da)57,670
- Last updated2001-03-01 v1
- Checksum2C585B9DC573F634
Q9HB55-2
- Name2
- Differences from canonical
- 417-417: E → ES
Q9HB55-3
- Name3
Q9HB55-4
- Name4
- NoteMay be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Q9HB55-6
- Name7
- Differences from canonical
- 56-224: GLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLIS → RSLNKIPSWAWWLTPVIPALWEAEAGGSPKVRSSRPALPTWVFGILTENVMKNTEKCGA
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_056736 | 56-224 | in isoform 7 | |||
Sequence: GLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLIS → RSLNKIPSWAWWLTPVIPALWEAEAGGSPKVRSSRPALPTWVFGILTENVMKNTEKCGA | ||||||
Alternative sequence | VSP_000612 | 224-250 | in isoform 4 | |||
Sequence: SLFPFLTPVFEALNIGLFPKDVTHFLK → YRVSLCCLGRSAWCDLGSLKPPPPGFE | ||||||
Alternative sequence | VSP_000613 | 251-503 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_000609 | 417 | in isoform 2 | |||
Sequence: E → ES | ||||||
Alternative sequence | VSP_000610 | 419-420 | in isoform 3 | |||
Sequence: FS → SH | ||||||
Alternative sequence | VSP_000611 | 421-503 | in isoform 3 | |||
Sequence: Missing |
Polymorphism
At protein level, three alleles are known: CYP3A43*1, CYP3A43*2 and CYP3A43*3. The sequence shown is that of CYP3A43*1, which is the most frequent allele. The allele CYP3A43*2 is likely to be non-functional.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF319634 EMBL· GenBank· DDBJ | AAK00325.1 EMBL· GenBank· DDBJ | mRNA | ||
AF337813 EMBL· GenBank· DDBJ | AAK38841.1 EMBL· GenBank· DDBJ | mRNA | ||
AF280107 EMBL· GenBank· DDBJ | AAG32291.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF280108 EMBL· GenBank· DDBJ | AAG33009.1 EMBL· GenBank· DDBJ | mRNA | ||
AF280109 EMBL· GenBank· DDBJ | AAG33010.1 EMBL· GenBank· DDBJ | mRNA | ||
AF280110 EMBL· GenBank· DDBJ | AAG33011.1 EMBL· GenBank· DDBJ | mRNA | ||
AF280111 EMBL· GenBank· DDBJ | AAG33012.1 EMBL· GenBank· DDBJ | mRNA | ||
AY390423 EMBL· GenBank· DDBJ | AAQ92351.1 EMBL· GenBank· DDBJ | mRNA | ||
AY390424 EMBL· GenBank· DDBJ | AAQ92352.1 EMBL· GenBank· DDBJ | mRNA | ||
AY390425 EMBL· GenBank· DDBJ | AAQ92353.1 EMBL· GenBank· DDBJ | mRNA | ||
AY390426 EMBL· GenBank· DDBJ | AAQ92354.1 EMBL· GenBank· DDBJ | mRNA | ||
AC011904 EMBL· GenBank· DDBJ | AAS07394.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC011904 EMBL· GenBank· DDBJ | AAS07395.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471091 EMBL· GenBank· DDBJ | EAW76632.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471091 EMBL· GenBank· DDBJ | EAW76634.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC100981 EMBL· GenBank· DDBJ | AAI00982.1 EMBL· GenBank· DDBJ | mRNA |