Q9HB29 · ILRL2_HUMAN

  • Protein
    Interleukin-1 receptor-like 2
  • Gene
    IL1RL2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity).
The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway

Catalytic activity

Features

Showing features for active site.

157550100150200250300350400450500550
TypeIDPosition(s)Description
Active site467

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functioninterleukin-1 receptor activity
Molecular Functioninterleukin-1, type I, activating receptor activity
Molecular FunctionNAD+ nucleosidase activity
Molecular FunctionNAD+ nucleotidase, cyclic ADP-ribose generating
Biological Processcellular defense response
Biological Processinflammatory response
Biological Processinnate immune response
Biological Processpositive regulation of interleukin-6 production
Biological Processpositive regulation of T cell differentiation
Biological Processregulation of inflammatory response
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Interleukin-1 receptor-like 2
  • EC number
  • Alternative names
    • IL-36 receptor (IL-36R)
    • Interleukin-1 receptor-related protein 2 (IL-1Rrp2; IL1R-rp2)

Gene names

    • Name
      IL1RL2
    • Synonyms
      IL1RRP2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9HB29
  • Secondary accessions
    • A4FU63
    • Q13525
    • Q45H74
    • Q53TU8
    • Q587I8

Proteomes

Organism-specific databases

Subcellular Location

Membrane ; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain20-335Extracellular
Transmembrane336-356Helical
Topological domain357-575Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_053378237in dbSNP:rs13405631
Natural variantVAR_025259352in dbSNP:rs33946385
Natural variantVAR_025260550in dbSNP:rs2302612

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 706 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_000001544520-575Interleukin-1 receptor-like 2
Glycosylation41N-linked (GlcNAc...) asparagine
Disulfide bond42↔95
Glycosylation59N-linked (GlcNAc...) asparagine
Glycosylation109N-linked (GlcNAc...) asparagine
Glycosylation127N-linked (GlcNAc...) asparagine
Disulfide bond146↔195
Glycosylation184N-linked (GlcNAc...) asparagine
Glycosylation234N-linked (GlcNAc...) asparagine
Disulfide bond249↔316
Glycosylation250N-linked (GlcNAc...) asparagine
Glycosylation266N-linked (GlcNAc...) asparagine
Glycosylation299N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN (By similarity).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-111Ig-like C2-type 1
Domain126-211Ig-like C2-type 2
Domain222-318Ig-like C2-type 3
Domain381-536TIR

Domain

The TIR domain mediates NAD+ hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.

Sequence similarities

Belongs to the interleukin-1 receptor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

Q9HB29-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    575
  • Mass (Da)
    65,405
  • Last updated
    2006-02-07 v2
  • Checksum
    7AC0FCAB43A2A6CD
MWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAYLIGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNILPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRRCRPFPPVQLLQHTPCYRTAGPELGSRRKKCTLTTG

Q9HB29-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-46: MWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFNCTFPP → MTGLVSLSYFPLSTRSCALQSCSPVWGCGPCCSAGCPSPFHCLSQQ
    • 47-163: Missing
    • 217-218: TE → K

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
C9K0I8C9K0I8_HUMANIL1RL2172

Sequence caution

The sequence AAB53237.1 differs from that shown. Reason: Frameshift

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0562921-46in isoform 2
Alternative sequenceVSP_05629347-163in isoform 2
Alternative sequenceVSP_056294217-218in isoform 2
Sequence conflict486in Ref. 1; AAG21368
Sequence conflict545-556in Ref. 2
Sequence conflict556in Ref. 1; AAG21368

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF284434
EMBL· GenBank· DDBJ
AAG21368.1
EMBL· GenBank· DDBJ
mRNA
U49065
EMBL· GenBank· DDBJ
AAB53237.1
EMBL· GenBank· DDBJ
mRNA Frameshift
DQ131903
EMBL· GenBank· DDBJ
AAZ38712.1
EMBL· GenBank· DDBJ
Genomic DNA
AC007271
EMBL· GenBank· DDBJ
AAX81989.1
EMBL· GenBank· DDBJ
Genomic DNA
AC007248
EMBL· GenBank· DDBJ
AAY15046.1
EMBL· GenBank· DDBJ
Genomic DNA
BC107064
EMBL· GenBank· DDBJ
AAI07065.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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