Q9HAC8 · UBTD1_HUMAN
- ProteinUbiquitin domain-containing protein 1
- GeneUBTD1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids227 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2.
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquitin domain-containing protein 1
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9HAC8
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 250 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000242674 | 1-227 | UniProt | Ubiquitin domain-containing protein 1 | |||
Sequence: MGNCVGRQRRERPAAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPPPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHAQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD | |||||||
Modified residue (large scale data) | 164 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with UBTD1.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9HAC8 | MID1 O15344 | 6 | EBI-745871, EBI-2340316 | |
BINARY | Q9HAC8 | MID2 Q9UJV3-2 | 3 | EBI-745871, EBI-10172526 | |
BINARY | Q9HAC8 | MRFAP1 Q9Y605 | 5 | EBI-745871, EBI-995714 | |
BINARY | Q9HAC8 | MRFAP1L1 Q96HT8 | 8 | EBI-745871, EBI-748896 | |
BINARY | Q9HAC8 | RNF5 Q99942 | 5 | EBI-745871, EBI-348482 | |
BINARY | Q9HAC8 | TP53BP2 Q05BL1 | 3 | EBI-745871, EBI-11952721 | |
BINARY | Q9HAC8 | TRAF6 Q9Y4K3 | 3 | EBI-745871, EBI-359276 | |
BINARY | Q9HAC8 | TRIM39 Q9HCM9 | 4 | EBI-745871, EBI-739510 | |
BINARY | Q9HAC8 | TRIM39 Q9HCM9-2 | 5 | EBI-745871, EBI-11523450 | |
BINARY | Q9HAC8 | TRIM50 Q86XT4 | 3 | EBI-745871, EBI-9867283 | |
BINARY | Q9HAC8 | UBE2D1 P51668 | 3 | EBI-745871, EBI-743540 | |
BINARY | Q9HAC8 | UBE2D2 P62837 | 8 | EBI-745871, EBI-347677 | |
BINARY | Q9HAC8 | UBE2D3 P61077 | 6 | EBI-745871, EBI-348268 | |
BINARY | Q9HAC8 | UBE2D4 Q9Y2X8 | 9 | EBI-745871, EBI-745527 | |
BINARY | Q9HAC8 | WWP2 O00308 | 3 | EBI-745871, EBI-743923 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-35 | Disordered | ||||
Sequence: MGNCVGRQRRERPAAPGHPRKRAGRNEPLKKERLK | ||||||
Compositional bias | 11-35 | Basic and acidic residues | ||||
Sequence: ERPAAPGHPRKRAGRNEPLKKERLK | ||||||
Domain | 149-224 | Ubiquitin-like | ||||
Sequence: FPLKVRLSTGKDVRLSASLPDTVGQLKRQLHAQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPP |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length227
- Mass (Da)25,938
- Last updated2001-03-01 v1
- Checksum7D34DB6027797255
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 11-35 | Basic and acidic residues | ||||
Sequence: ERPAAPGHPRKRAGRNEPLKKERLK | ||||||
Sequence conflict | 133 | in Ref. 2; BAD96317 | ||||
Sequence: E → G | ||||||
Sequence conflict | 173 | in Ref. 2; BAD96317 | ||||
Sequence: Q → L |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK021869 EMBL· GenBank· DDBJ | BAB13921.1 EMBL· GenBank· DDBJ | mRNA | ||
AK222597 EMBL· GenBank· DDBJ | BAD96317.1 EMBL· GenBank· DDBJ | mRNA | ||
AL359388 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471066 EMBL· GenBank· DDBJ | EAW49918.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471066 EMBL· GenBank· DDBJ | EAW49919.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC007331 EMBL· GenBank· DDBJ | AAH07331.1 EMBL· GenBank· DDBJ | mRNA |