Q9H9F9 · ARP5_HUMAN
- ProteinActin-related protein 5
- GeneACTR5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids607 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | Ino80 complex | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Biological Process | chromatin remodeling | |
Biological Process | DNA recombination | |
Biological Process | double-strand break repair | |
Biological Process | positive regulation of DNA repair | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | positive regulation of telomere maintenance in response to DNA damage | |
Biological Process | regulation of cell cycle | |
Biological Process | regulation of chromosome organization | |
Biological Process | regulation of DNA repair | |
Biological Process | regulation of DNA replication | |
Biological Process | regulation of DNA strand elongation | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | regulation of embryonic development | |
Biological Process | telomere maintenance | |
Biological Process | UV-damage excision repair |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameActin-related protein 5
- Short nameshARP5
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9H9F9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_027158 | 298 | in dbSNP:rs17853829 | |||
Sequence: R → L | ||||||
Natural variant | VAR_048189 | 461 | in dbSNP:rs35805905 | |||
Sequence: I → L | ||||||
Natural variant | VAR_027159 | 483 | in dbSNP:rs2245231 | |||
Sequence: I → V | ||||||
Natural variant | VAR_027160 | 580 | in dbSNP:rs3752289 | |||
Sequence: P → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 710 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), cross-link.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000247842 | 1-607 | UniProt | Actin-related protein 5 | |||
Sequence: MAANVFPFRDARAAPDPVLEAGPVAHGPLPVPLVLDNGSFQVRAGWACPGQDPGPEPRLQFRAVCARGRGGARGASGPQVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYGIPKVAYGIDSLFSFYHNKPKNSMCSGLIISSGYQCTHVLPILEGRLDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVEELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHKALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFRSSFQVQLASNPVLDAWYGARDWALNHLDDNEVWITRKEYEEKGGEYLKEHCASNIYVPIRLPKQASRSSDAQASSKGSAAGGGGAGEQA | |||||||
Modified residue (large scale data) | 76 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Cross-link | 283 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 291 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Interacts with DDB1. Interacts with ACTR8; the interaction is observed in asynchronous (interphase) cells but not in metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic cells.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9H9F9 | ACTR8 Q9H981 | 3 | EBI-769418, EBI-769597 | |
BINARY | Q9H9F9 | DDB1 Q16531 | 4 | EBI-769418, EBI-350322 | |
BINARY | Q9H9F9 | INO80 Q9ULG1 | 10 | EBI-769418, EBI-769345 | |
BINARY | Q9H9F9 | INO80C Q6PI98 | 4 | EBI-769418, EBI-722540 | |
BINARY | Q9H9F9 | PPL O60437 | 3 | EBI-769418, EBI-368321 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for coiled coil, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 288-327 | |||||
Sequence: TLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRL | ||||||
Coiled coil | 355-384 | |||||
Sequence: EELQSYIQKLSIAVEQAKQKILQAEVNLEV | ||||||
Region | 584-607 | Disordered | ||||
Sequence: SRSSDAQASSKGSAAGGGGAGEQA |
Sequence similarities
Belongs to the actin family. ARP5 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length607
- Mass (Da)68,297
- Last updated2006-07-25 v2
- ChecksumDA3E50AE37BCC363
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 69-70 | in Ref. 4; AAO65164 | ||||
Sequence: RG → AR | ||||||
Sequence conflict | 481 | in Ref. 1; BAB14270 | ||||
Sequence: K → E |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK022847 EMBL· GenBank· DDBJ | BAB14270.1 EMBL· GenBank· DDBJ | mRNA | ||
AL133519 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC001324 EMBL· GenBank· DDBJ | AAH01324.1 EMBL· GenBank· DDBJ | mRNA | ||
BC006162 EMBL· GenBank· DDBJ | AAH06162.1 EMBL· GenBank· DDBJ | mRNA | ||
BC038402 EMBL· GenBank· DDBJ | AAH38402.1 EMBL· GenBank· DDBJ | mRNA | ||
AY211911 EMBL· GenBank· DDBJ | AAO65164.1 EMBL· GenBank· DDBJ | mRNA | Frameshift |