Q9H7C9 · AAMDC_HUMAN

  • Protein
    Mth938 domain-containing protein
  • Gene
    AAMDC
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

May play a role in preadipocyte differentiation and adipogenesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Biological Processpositive regulation of fat cell differentiation

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mth938 domain-containing protein
  • Alternative names
    • Adipogenesis associated Mth938 domain-containing protein

Gene names

    • Name
      AAMDC
    • Synonyms
      C11orf67
    • ORF names
      PTD015

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9H7C9
  • Secondary accessions
    • Q96AQ4
    • Q9Y6B1

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Note: Diffuse distribution with some highly concentrated spots around the nucleus.

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_05269692in dbSNP:rs2186564

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 134 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002398141-122UniProtMth938 domain-containing protein
Modified residue (large scale data)43PRIDEPhosphothreonine
Modified residue (large scale data)46PRIDEPhosphoserine

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region6-122MTH138-like domain

Sequence similarities

Belongs to the AAMDC family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q9H7C9-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    122
  • Mass (Da)
    13,332
  • Last updated
    2001-03-01 v1
  • Checksum
    A0C88AD311E62C78
MTSPEIASLSWGQMKVKGSNTTYKDCKVWPGGSRTWDWRETGTEHSPGVQPADVKEVVEKGVQTLVIGRGMSEALKVPSSTVEYLKKHGIDVRVLQTEQAVKEYNALVAQGVRVGGVFHSTC

Q9H7C9-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 77-118: VPSSTVEYLKKHGIDVRVLQTEQAVKEYNALVAQGVRVGGVF → APTQQLPSGVHVRAGVQFHLLQLHGTSFERCKTGAGLTSNML
    • 119-122: Missing

Q9H7C9-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 77-88: VPSSTVEYLKKH → DGIQGAQLDLNC
    • 89-122: Missing

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YF35H0YF35_HUMANAAMDC51
K4DI89K4DI89_HUMANAAMDC147
E9PR47E9PR47_HUMANAAMDC168
E9PNP3E9PNP3_HUMANAAMDC141
E9PLK9E9PLK9_HUMANAAMDC137
E9PIQ4E9PIQ4_HUMANAAMDC90
E9PJP1E9PJP1_HUMANAAMDC93

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_01926677-88in isoform 3
Alternative sequenceVSP_01926777-118in isoform 2
Alternative sequenceVSP_01926889-122in isoform 3
Alternative sequenceVSP_019269119-122in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF092136
EMBL· GenBank· DDBJ
AAD40378.1
EMBL· GenBank· DDBJ
mRNA
AK024688
EMBL· GenBank· DDBJ
BAB14963.1
EMBL· GenBank· DDBJ
mRNA
CR457332
EMBL· GenBank· DDBJ
CAG33613.1
EMBL· GenBank· DDBJ
mRNA
AP000580
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AP002812
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC002752
EMBL· GenBank· DDBJ
AAH02752.1
EMBL· GenBank· DDBJ
mRNA
BC016854
EMBL· GenBank· DDBJ
AAH16854.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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