Q9H6R4 · NOL6_HUMAN

  • Protein
    Nucleolar protein 6
  • Gene
    NOL6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcondensed nuclear chromosome
Cellular ComponentCURI complex
Cellular Componentmitochondrion
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular Componentsmall-subunit processome
Cellular ComponentUTP-C complex
Molecular FunctionRNA binding
Biological Processribosomal small subunit biogenesis
Biological ProcessrRNA processing
Biological ProcesstRNA export from nucleus

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nucleolar protein 6
  • Alternative names
    • Nucleolar RNA-associated protein
      (Nrap
      )

Gene names

    • Name
      NOL6

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9H6R4
  • Secondary accessions
    • Q5T5M3
    • Q5T5M4
    • Q7L4G6
    • Q8N6I0
    • Q8TEY9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_05354152in dbSNP:rs10971523
Natural variantVAR_053542723in dbSNP:rs35135082

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,227 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00002156471-1146UniProtNucleolar protein 6
Modified residue (large scale data)27PRIDEPhosphothreonine
Modified residue56UniProtPhosphoserine
Modified residue (large scale data)121PRIDEPhosphoserine
Modified residue283UniProtPhosphoserine
Modified residue (large scale data)283PRIDEPhosphoserine
Modified residue289UniProtPhosphoserine
Modified residue (large scale data)289PRIDEPhosphoserine
Modified residue811UniProtPhosphoserine
Modified residue (large scale data)811PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797).
Interacts with RRP7A; required for NOL6 localization to nucleolus (PubMed:33199730).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9H6R4JPH3 Q8WXH23EBI-2514288, EBI-1055254
BINARY Q9H6R4-4SIAH1 Q8IUQ43EBI-10307896, EBI-747107
View interactors in UniProtKB
View CPX-2511 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Region1-48Disordered
Compositional bias23-40Basic and acidic residues
Coiled coil83-114

Sequence similarities

Belongs to the NRAP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q9H6R4-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    Alpha, Long
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    1,146
  • Mass (Da)
    127,593
  • Last updated
    2005-04-26 v2
  • Checksum
    2E73D31BC3D4AF6B
MGPAPAGEQLRGATGEPEVMEPALEGTGKEGKKASSRKRTLAEPPAKGLLQPVKLSRAELYKEPTNEELNRLRETEILFHSSLLRLQVEELLKEVRLSEKKKDRIDAFLREVNQRVVRVPSVPETELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPDINVDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDPLFGSVCFSYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVRSAWYRGQSPAGDGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLKDGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVLRSVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNLCADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPMIRAFDHVLHLRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLLAHSRPPVPEWDISQDPPKHKDSGTLTLGLLLRPEGLTSVLELGPEADQPEAAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLALHADIPETCVHYVGGPLDALIQGLKETSSTGEEALVAAVRCYDDLSRLLWGLEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLDKPCPAYVEPMTVVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGLQCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASLRLERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADESLDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNPLFVNLNNELTVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVVLAAEALPMLEKQLMDPRGPGDIRTVFRPPLDIYDVLIRLSPRHIPRHRQAVDSPAASFCRGLLSQPGPSSLMPVLGYDPPQLYLTQLREAFGDLALFFYDQHGGEVIGVLWKPTSFQPQPFKASSTKGRMVMSRGGELVMVPNVEAILEDFAVLGEGLVQTVEARSERWTV

Q9H6R4-2

  • Name
    2
  • Synonyms
    Beta, Mid
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 999-1146: TVFRPPLDIYDVLIRLSPRHIPRHRQAVDSPAASFCRGLLSQPGPSSLMPVLGYDPPQLYLTQLREAFGDLALFFYDQHGGEVIGVLWKPTSFQPQPFKASSTKGRMVMSRGGELVMVPNVEAILEDFAVLGEGLVQTVEARSERWTV → WDPAKMWPF

Q9H6R4-3

  • Name
    3
  • Synonyms
    Gamma, Short
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9H6R4-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0A0MRW6A0A0A0MRW6_HUMANNOL61008
A0A0C4DFX0A0A0C4DFX0_HUMANNOL6200

Sequence caution

The sequence AAH08298.1 differs from that shown. Reason: Erroneous initiation
The sequence BAB15189.1 differs from that shown. Reason: Erroneous initiation
The sequence BAB15389.1 differs from that shown. Reason: Miscellaneous discrepancy Intron retention.

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias23-40Basic and acidic residues
Alternative sequenceVSP_013530383-385in isoform 4
Alternative sequenceVSP_013531651-1097in isoform 3
Alternative sequenceVSP_013532999-1146in isoform 2
Sequence conflict1098in Ref. 1; AAL74405

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF361079
EMBL· GenBank· DDBJ
AAL74403.1
EMBL· GenBank· DDBJ
mRNA
AF361080
EMBL· GenBank· DDBJ
AAL74404.1
EMBL· GenBank· DDBJ
mRNA
AF361081
EMBL· GenBank· DDBJ
AAL74405.1
EMBL· GenBank· DDBJ
mRNA
AL356218
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC008298
EMBL· GenBank· DDBJ
AAH08298.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC008852
EMBL· GenBank· DDBJ
AAH08852.2
EMBL· GenBank· DDBJ
mRNA
BC030139
EMBL· GenBank· DDBJ
AAH30139.1
EMBL· GenBank· DDBJ
mRNA
AK025612
EMBL· GenBank· DDBJ
BAB15189.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK026193
EMBL· GenBank· DDBJ
BAB15389.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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