X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 19-184 IN COMPLEX WITH TEN1, X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 191-368, DNA-BINDING, WHTH REGIONS, MUTAGENESIS OF ASP-78; ILE-164 AND MET-167
Categories
Function, Family & Domains, Disease & Variants, Interaction, Structure
The study investigated whether six genetic variants previously associated with leukocyte telomere length are correlated with telomere length in peripheral blood mononuclear cells in a cohort of Africans living with and without HIV and undergoing evaluation for tuberculosis (TB). OBFC1 and the genetic sum score of the effect alleles across all six loci were found to be associated with shorter telomere length.
we explored two SNPs in genes associated either with telomere biology (OBFC1) or with LTL (OBCF1 and CTC1). Interestingly we observed that genetic variation does not account for LTL at birth
Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
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