Q9H4D5 · NXF3_HUMAN
- ProteinNuclear RNA export factor 3
- GeneNXF3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids531 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May function as a tissue-specific nuclear mRNA export factor.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nuclear RNA export factor complex | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | RNA binding | |
Biological Process | mRNA export from nucleus | |
Biological Process | poly(A)+ mRNA export from nucleus |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNuclear RNA export factor 3
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9H4D5
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_050419 | 186 | in dbSNP:rs2301387 | |||
Sequence: N → I | ||||||
Mutagenesis | 300 | Inactivates CRM1 binding; when associated with R-302. | ||||
Sequence: L → R | ||||||
Mutagenesis | 302 | Inactivates CRM1 binding; when associated with R-300. | ||||
Sequence: L → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 457 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000220534 | 1-531 | UniProt | Nuclear RNA export factor 3 | |||
Sequence: MSLPSGHTTGHTDQVVQRRARCWDIYQRRFSSRSEPVNPGMHSSSHQQQDGDAAMHGAHMDSPVRYTPYTISPYNRKGSFRKQDQTHVNMEREQKPPERRMEGNMPDGTLGSWFKITVPFGIKYNEKWLLNLIQNECSVPFVPVEFHYENMHASFFVENASIAYALKNVSGKIWDEDNEKISIFVNPAGIPHFVHRELKSEKVEQIKLAMNQQCDVSQEALDIQRLPFYPDMVNRDTKMASNPRKCMAASLDVHEENIPTVMSAGEMDKWKGIEPGEKCADRSPVCTTFSDTSSNINSILELFPKLLCLDGQQSPRATLCGTEAHKRLPTCKGSFFGSEMLKNLVLQFLQQYYLIYDSGDRQGLLSAYHDEACFSLSIPFNPEDSAPSSFCKFFKDSRNIKILKDPYLRGELLKHTKLDIVDSLSALPKTQHDLSSFLVDMWYQTEWMLCFSVNGVFKEVEGQSQGSVLAFTRTFIATPGSSSSLCIVNDKLFVRDTSHQGTQSALFTLVPTAFSSSVPAFSQEQQKMLPS | |||||||
Modified residue (large scale data) | 314 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed at high level in testis and at low level in a small number of tissues.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with NXT1, NXT2, E1B-AP5 and CRM1 nuclear export factor.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9H4D5 | NXT1 Q9UKK6 | 17 | EBI-750038, EBI-301889 | |
BINARY | Q9H4D5 | NXT2 Q9NPJ8 | 9 | EBI-750038, EBI-752122 | |
BINARY | Q9H4D5 | NXT2 Q9NPJ8-3 | 9 | EBI-750038, EBI-10698339 | |
BINARY | Q9H4D5 | SKIL P12757 | 3 | EBI-750038, EBI-2902468 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 33-51 | Polar residues | ||||
Sequence: RSEPVNPGMHSSSHQQQDG | ||||||
Region | 33-59 | Disordered | ||||
Sequence: RSEPVNPGMHSSSHQQQDGDAAMHGAH | ||||||
Compositional bias | 83-102 | Basic and acidic residues | ||||
Sequence: QDQTHVNMEREQKPPERRME | ||||||
Region | 83-106 | Disordered | ||||
Sequence: QDQTHVNMEREQKPPERRMEGNMP | ||||||
Domain | 113-192 | RRM | ||||
Sequence: WFKITVPFGIKYNEKWLLNLIQNECSVPFVPVEFHYENMHASFFVENASIAYALKNVSGKIWDEDNEKISIFVNPAGIPH | ||||||
Domain | 344-494 | NTF2 | ||||
Sequence: LVLQFLQQYYLIYDSGDRQGLLSAYHDEACFSLSIPFNPEDSAPSSFCKFFKDSRNIKILKDPYLRGELLKHTKLDIVDSLSALPKTQHDLSSFLVDMWYQTEWMLCFSVNGVFKEVEGQSQGSVLAFTRTFIATPGSSSSLCIVNDKLFV |
Domain
Lacks C-terminal domain that mediates direct interactions with nucleoporins.
Contains a novel CRM1-dependent nuclear export signal that compensates in cis for the loss of the nuclear pore targeting domain.
The RNA-binding domain is a non-canonical RNP-type domain.
Sequence similarities
Belongs to the NXF family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9H4D5-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length531
- Mass (Da)60,102
- Last updated2001-03-01 v1
- Checksum3A47C7D35FC396B9
Q9H4D5-2
- Name2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H0Y6A1 | H0Y6A1_HUMAN | NXF3 | 361 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_057068 | 1-89 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 33-51 | Polar residues | ||||
Sequence: RSEPVNPGMHSSSHQQQDG | ||||||
Compositional bias | 83-102 | Basic and acidic residues | ||||
Sequence: QDQTHVNMEREQKPPERRME | ||||||
Alternative sequence | VSP_057069 | 297-322 | in isoform 2 | |||
Sequence: NSILELFPKLLCLDGQQSPRATLCGT → KSVVPSVTTWDPDLCLIAPFCRRRQH | ||||||
Alternative sequence | VSP_057070 | 323-531 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ277527 EMBL· GenBank· DDBJ | CAC16589.1 EMBL· GenBank· DDBJ | mRNA | ||
AF346619 EMBL· GenBank· DDBJ | AAL07564.1 EMBL· GenBank· DDBJ | mRNA | ||
AK302586 EMBL· GenBank· DDBJ | BAG63839.1 EMBL· GenBank· DDBJ | mRNA | ||
Z75746 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471190 EMBL· GenBank· DDBJ | EAW54722.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC031616 EMBL· GenBank· DDBJ | AAH31616.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ277660 EMBL· GenBank· DDBJ | CAC20434.1 EMBL· GenBank· DDBJ | mRNA | Frameshift |