Q9H4D5 · NXF3_HUMAN

  • Protein
    Nuclear RNA export factor 3
  • Gene
    NXF3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May function as a tissue-specific nuclear mRNA export factor.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnuclear RNA export factor complex
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionRNA binding
Biological ProcessmRNA export from nucleus
Biological Processpoly(A)+ mRNA export from nucleus

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear RNA export factor 3
  • Alternative names
    • TAP-like protein 3 (TAPL-3)

Gene names

    • Name
      NXF3
    • Synonyms
      TAPL3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9H4D5
  • Secondary accessions
    • B4DYS7
    • Q5H9I1
    • Q9H1A9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant, mutagenesis.

TypeIDPosition(s)Description
Natural variantVAR_050419186in dbSNP:rs2301387
Mutagenesis300Inactivates CRM1 binding; when associated with R-302.
Mutagenesis302Inactivates CRM1 binding; when associated with R-300.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 457 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002205341-531UniProtNuclear RNA export factor 3
Modified residue (large scale data)314PRIDEPhosphoserine

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed at high level in testis and at low level in a small number of tissues.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with NXT1, NXT2, E1B-AP5 and CRM1 nuclear export factor.

Binary interactions

View interactors in UniProtKB
View CPX-2436 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias33-51Polar residues
Region33-59Disordered
Compositional bias83-102Basic and acidic residues
Region83-106Disordered
Domain113-192RRM
Domain344-494NTF2

Domain

Lacks C-terminal domain that mediates direct interactions with nucleoporins.
Contains a novel CRM1-dependent nuclear export signal that compensates in cis for the loss of the nuclear pore targeting domain.
The RNA-binding domain is a non-canonical RNP-type domain.

Sequence similarities

Belongs to the NXF family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9H4D5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    531
  • Mass (Da)
    60,102
  • Last updated
    2001-03-01 v1
  • Checksum
    3A47C7D35FC396B9
MSLPSGHTTGHTDQVVQRRARCWDIYQRRFSSRSEPVNPGMHSSSHQQQDGDAAMHGAHMDSPVRYTPYTISPYNRKGSFRKQDQTHVNMEREQKPPERRMEGNMPDGTLGSWFKITVPFGIKYNEKWLLNLIQNECSVPFVPVEFHYENMHASFFVENASIAYALKNVSGKIWDEDNEKISIFVNPAGIPHFVHRELKSEKVEQIKLAMNQQCDVSQEALDIQRLPFYPDMVNRDTKMASNPRKCMAASLDVHEENIPTVMSAGEMDKWKGIEPGEKCADRSPVCTTFSDTSSNINSILELFPKLLCLDGQQSPRATLCGTEAHKRLPTCKGSFFGSEMLKNLVLQFLQQYYLIYDSGDRQGLLSAYHDEACFSLSIPFNPEDSAPSSFCKFFKDSRNIKILKDPYLRGELLKHTKLDIVDSLSALPKTQHDLSSFLVDMWYQTEWMLCFSVNGVFKEVEGQSQGSVLAFTRTFIATPGSSSSLCIVNDKLFVRDTSHQGTQSALFTLVPTAFSSSVPAFSQEQQKMLPS

Q9H4D5-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-89: Missing
    • 297-322: NSILELFPKLLCLDGQQSPRATLCGT → KSVVPSVTTWDPDLCLIAPFCRRRQH
    • 323-531: Missing

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
H0Y6A1H0Y6A1_HUMANNXF3361

Sequence caution

The sequence CAC20434.1 differs from that shown. Reason: Frameshift

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0570681-89in isoform 2
Compositional bias33-51Polar residues
Compositional bias83-102Basic and acidic residues
Alternative sequenceVSP_057069297-322in isoform 2
Alternative sequenceVSP_057070323-531in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ277527
EMBL· GenBank· DDBJ
CAC16589.1
EMBL· GenBank· DDBJ
mRNA
AF346619
EMBL· GenBank· DDBJ
AAL07564.1
EMBL· GenBank· DDBJ
mRNA
AK302586
EMBL· GenBank· DDBJ
BAG63839.1
EMBL· GenBank· DDBJ
mRNA
Z75746
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471190
EMBL· GenBank· DDBJ
EAW54722.1
EMBL· GenBank· DDBJ
Genomic DNA
BC031616
EMBL· GenBank· DDBJ
AAH31616.1
EMBL· GenBank· DDBJ
mRNA
AJ277660
EMBL· GenBank· DDBJ
CAC20434.1
EMBL· GenBank· DDBJ
mRNA Frameshift

Genome annotation databases

Similar Proteins

Disclaimer

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