Q9H320 · VCX1_HUMAN
- ProteinVariable charge X-linked protein 1
- GeneVCX
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids206 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
May mediate a process in spermatogenesis or may play a role in sex ratio distortion.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleolus | |
Cellular Component | nucleus | |
Molecular Function | chromatin binding | |
Biological Process | brain development | |
Biological Process | chromatin organization | |
Biological Process | ribosome assembly | |
Biological Process | spermatogenesis |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVariable charge X-linked protein 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9H320
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_070431 | 70 | in dbSNP:rs6639946 | |||
Sequence: A → G | ||||||
Natural variant | VAR_070432 | 194 | in dbSNP:rs78342118 | |||
Sequence: P → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 478 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000184659 | 1-206 | Variable charge X-linked protein 1 | |||
Sequence: MSPKPRASGPPAKATEAGKRKSSSQPSPSDPKKKTTKVAKKGKAVRRGRRGKKGAATKMAAVTAPEAESAPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQEAELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEEPLSQESQVEEPPSQESEMEELPSV |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed exclusively in testis.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-206 | Disordered | ||||
Sequence: MSPKPRASGPPAKATEAGKRKSSSQPSPSDPKKKTTKVAKKGKAVRRGRRGKKGAATKMAAVTAPEAESAPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQEAELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEEPLSQESQVEEPPSQESEMEELPSV | ||||||
Compositional bias | 18-32 | Polar residues | ||||
Sequence: GKRKSSSQPSPSDPK | ||||||
Compositional bias | 36-54 | Basic residues | ||||
Sequence: TKVAKKGKAVRRGRRGKKG | ||||||
Repeat | 104-113 | 1 | ||||
Sequence: LSQEAELEEP | ||||||
Region | 104-203 | 10 X 10 AA tandem repeats of L-S-Q-E-S-[EQ]-V-E-E-P | ||||
Sequence: LSQEAELEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEEPLSQESQVEEPPSQESEMEEL | ||||||
Repeat | 114-123 | 2 | ||||
Sequence: LSQESEVEEP | ||||||
Compositional bias | 119-193 | Polar residues | ||||
Sequence: EVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEEPLSQESQVEEP | ||||||
Repeat | 124-133 | 3 | ||||
Sequence: LSQESQVEEP | ||||||
Repeat | 134-143 | 4 | ||||
Sequence: LSQESEVEEP | ||||||
Repeat | 144-153 | 5 | ||||
Sequence: LSQESQVEEP | ||||||
Repeat | 154-163 | 6 | ||||
Sequence: LSQESEVEEP | ||||||
Repeat | 164-173 | 7 | ||||
Sequence: LSQESQVEEP | ||||||
Repeat | 174-183 | 8 | ||||
Sequence: LSQESEMEEP | ||||||
Repeat | 184-193 | 9 | ||||
Sequence: LSQESQVEEP | ||||||
Repeat | 194-203 | 10 | ||||
Sequence: PSQESEMEEL |
Sequence similarities
Belongs to the VCX/VCY family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length206
- Mass (Da)22,289
- Last updated2001-03-01 v1
- Checksum070880B5587C2BB0
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
J3KNW2 | J3KNW2_HUMAN | VCX | 186 | ||
A0A8I5QKN2 | A0A8I5QKN2_HUMAN | VCX | 166 | ||
A0A087X1S4 | A0A087X1S4_HUMAN | VCX | 186 |
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 15-17 | in Ref. 3; AAH98123 | ||||
Sequence: TEA → KET | ||||||
Compositional bias | 18-32 | Polar residues | ||||
Sequence: GKRKSSSQPSPSDPK | ||||||
Compositional bias | 36-54 | Basic residues | ||||
Sequence: TKVAKKGKAVRRGRRGKKG | ||||||
Sequence conflict | 108 | in Ref. 3; AAH98123 | ||||
Sequence: A → S | ||||||
Compositional bias | 119-193 | Polar residues | ||||
Sequence: EVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEVEEPLSQESQVEEPLSQESEMEEPLSQESQVEEP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF167081 EMBL· GenBank· DDBJ | AAG41767.1 EMBL· GenBank· DDBJ | mRNA | ||
AF159129 EMBL· GenBank· DDBJ | AAF28174.1 EMBL· GenBank· DDBJ | mRNA | ||
BC098123 EMBL· GenBank· DDBJ | AAH98123.1 EMBL· GenBank· DDBJ | mRNA | ||
BC126903 EMBL· GenBank· DDBJ | AAI26904.1 EMBL· GenBank· DDBJ | mRNA |