The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.Wai T., Saita S., Nolte H., Muller S., Konig T., Richter-Dennerlein R., Sprenger H.G., Madrenas J., Muhlmeister M.[...], Langer T.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-5333637PubMedEurope PMCEMBO Rep 17:1844-1856 (2016)Mapped to6
The m-AAA protease associated with neurodegeneration limits MCU activity in mitochondria.Koenig T., Troeder S.E., Bakka K., Korwitz A., Richter-Dennerlein R., Lampe P.A., Patron M., Muehlmeister M., Guerrero-Castillo S.[...], Langer T.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-5333637PubMedEurope PMCMol. Cell 64:148-162 (2016)Cited in5Mapped to20
PINK1 cleavage at position A103 by the mitochondrial protease PARL.Deas E., Plun-Favreau H., Gandhi S., Desmond H., Kjaer S., Loh S.H., Renton A.E., Harvey R.J., Whitworth A.J.[...], Wood N.W.View abstractCategoriesFunctionSourceMEROPS: S54.009PubMedEurope PMCHum Mol Genet 20:867-879 (2011)Mapped to9
The Leu262Val polymorphism of presenilin associated rhomboid like protein (PARL) is associated with earlier onset of type 2 diabetes and increased urinary microalbumin creatinine ratio in an Irish case-control population.Hatunic M., Stapleton M., Hand E., DeLong C., Crowley V.E., Nolan J.J.View abstractAnnotationAssociated with METABOLIC: diabetes, type 2.CategoriesDisease & VariantsSourceGAD:566907PubMedEurope PMCDiabetes Res Clin Pract 83:316-319 (2009)Mapped to2
PARL Leu262Val is not associated with fasting insulin levels in UK populations.Fawcett K.A., Wareham N.J., Luan J., Syddall H., Cooper C., O'Rahilly S., Day I.N., Sandhu M.S., Barroso I.View abstractAnnotationNot Associated with METABOLIC: insulin.CategoriesDisease & VariantsSourceGAD:152391PubMedEurope PMCDiabetologia 49:2649-2652 (2006)Mapped to2